The role of paraoxonase in cancer.

Animals Apoptosis Aryldialkylphosphatase / chemistry Biomarkers, Tumor Diet Disease Susceptibility Gene Expression Regulation, Neoplastic Humans Multigene Family Neoplasms / etiology Oxidative Stress Risk Factors Signal Transduction
Apoptosis Cancer Oxidative stress Paraoxonase

Journal

Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218

Informations de publication

Date de publication:
06 2019
Historique:
received: 20 07 2017
revised: 20 10 2017
accepted: 18 11 2017
pubmed: 25 11 2017
medline: 4 4 2020
entrez: 25 11 2017
Statut: ppublish

Résumé

The paraoxonase (PON) gene family includes three proteins, PON1, PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert anti-oxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes which modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER) stress-induced apoptosis. The pleiotropic roles exerted by PONs have been mainly investigated in cardiovascular and neurodegenerative diseases. In recent years, overexpression of PON2 and PON3 has been observed in cancer cells and it has been proposed that both enzymes could be involved in tumor survival and stress resistance. Moreover, a lower activity of serum PON1 has been reported in cancer patients. This review summarizes literature data on the role of PONs in human cancers and their potential role as a target for antitumor drugs.

Identifiants

DOI: 10.1016/j.semcancer.2017.11.013 PMID: 29170064
pubmed: 29170064
pii: S1044-579X(17)30191-8
doi: 10.1016/j.semcancer.2017.11.013
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
Aryldialkylphosphatase EC 3.1.8.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

72-86

Informations de copyright

Copyright © 2017 Elsevier Ltd. All rights reserved.

Auteurs

Tiziana Bacchetti (T)

Department of Life and Environmental Sciences (DiSVA), Polytechnic University of Marche, Ancona, Italy. Electronic address: t.bacchetti@univpm.it.

Gianna Ferretti (G)

Department of Clinical Science and Odontostomatology, Polytechnic University of Marche, Ancona, Italy. Electronic address: g.ferretti@univpm.it.

Amirhossein Sahebkar (A)

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: amir_saheb2000@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › The role of paraoxonase in cancer.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric triester hydrolases › Aryldialkylphosphatase › The role of paraoxonase in cancer.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › The role of paraoxonase in cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › The role of paraoxonase in cancer.
questionsmedicales.fr › Tumeurs › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The role of paraoxonase in cancer.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The role of paraoxonase in cancer.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The role of paraoxonase in cancer.