Granzyme B in skin inflammation and disease.

Animals Apoptosis / genetics Chronic Disease Fibrosis / genetics Granzymes / genetics Humans Inflammation / genetics Skin / growth & development Skin Aging / genetics Skin Diseases / genetics
Extracellular matrix Granzyme B Inflammatory skin disease Serine protease

Journal

Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592

Informations de publication

Date de publication:
01 2019
Historique:
received: 16 10 2017
revised: 11 12 2017
accepted: 12 12 2017
pubmed: 17 12 2017
medline: 19 6 2019
entrez: 17 12 2017
Statut: ppublish

Résumé

Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated in chronic disease and inflammatory skin disorders, including diabetic ulcers, hypertrophic scarring, autoimmune skin disorders, cutaneous leishmaniasis and aging skin. Traditionally known for its pro-apoptotic function, the role of GzmB in disease has been redefined due to the discovery of additional activities involving the cleavage of extracellular matrix proteins, epithelial barrier disruption, fibrosis, vascular permeability, anoikis, inflammation and autoimmunity. In addition to the accumulation of GzmB

Identifiants

DOI: 10.1016/j.matbio.2017.12.005 PMID: 29247692
pubmed: 29247692
pii: S0945-053X(17)30335-9
doi: 10.1016/j.matbio.2017.12.005
pii:
doi:

Substances chimiques

GZMB protein, human EC 3.4.21.-
Granzymes EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-140

Subventions

Organisme : CIHR
ID : 152477
Pays : Canada

Informations de copyright

Copyright © 2019 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

Auteurs

Christopher T Turner (CT)

International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 818 West 10th Ave., Vancouver V5Z 1M9, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, BC, Canada.

Darielle Lim (D)

International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 818 West 10th Ave., Vancouver V5Z 1M9, BC, Canada.

David J Granville (DJ)

International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 818 West 10th Ave., Vancouver V5Z 1M9, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, BC, Canada; British Columbia Professional Firefighters' Burn and Wound Healing Group, Vancouver, BC, Canada. Electronic address: david.granville@hli.ubc.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › Système tégumentaire › Peau › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Vieillissement de la peau › Granzyme B in skin inflammation and disease.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Granzyme B in skin inflammation and disease.