Cognitive impairment, clinical severity and MRI changes in MELAS syndrome.
Cognitive impairment
Dementia
MELAS
MRI
Mitochondrial disorders
Journal
Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
10
06
2017
revised:
05
12
2017
accepted:
27
12
2017
pubmed:
1
1
2018
medline:
9
3
2019
entrez:
1
1
2018
Statut:
ppublish
Résumé
To examine clinical severity, cognitive impairment, and MRI changes in patients with MELAS syndrome. Cognitive-mnestic functions, brain MRI (lesion load, cella media index) and clinical severity of ten patients with MELAS syndrome were examined. All patients carried the m.3243A>G mutation. The detailed neuropsychological assessment revealed cognitive deficits in attention, executive function, visuoperception, and -construction. There were significant correlations between these cognitive changes, lesion load in MRI, disturbances in everyday life (clinical scale), and high scores in NMDAS. Patients with MELAS syndrome showed no global neuropsychological deficit, but rather distinct cognitive deficits.
Identifiants
pubmed: 29289801
pii: S1567-7249(17)30162-9
doi: 10.1016/j.mito.2017.12.012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-57Informations de copyright
Copyright © 2018 Elsevier B.V. and Mitochondria Research Society. All rights reserved.