Three new Lycopodium alkaloids from Lycopodium japonicum.

Alkaloids / chemistry Calcium Channel Blockers / isolation & purification Calcium Channels, T-Type / drug effects HEK293 Cells Humans Lycopodium / chemistry Magnetic Resonance Spectroscopy
None alkaloids Lycopodiaceae T-type calcium channel

Journal

Journal of Asian natural products research
ISSN: 1477-2213
Titre abrégé: J Asian Nat Prod Res
Pays: England
ID NLM: 100888334

Informations de publication

Date de publication:
Jan 2019
Historique:
pubmed: 28 1 2018
medline: 11 9 2019
entrez: 28 1 2018
Statut: ppublish

Résumé

Three new Lycopodium alkaloids (1-3), together with 15 known alkaloids, were isolated from club moss Lycopodium japonicum. Their structures were determined by extensive spectroscopic analysis, including 1D and 2D NMR spectra. Compound 1 has an unusual β-oriented methyl group substituted at C-15 and an α-hydroxy cyclopentenone moiety. All new alkaloids were evaluated for the inhibition of T-type calcium channel.

Identifiants

DOI: 10.1080/10286020.2018.1427075 PMID: 29373928
pubmed: 29373928
doi: 10.1080/10286020.2018.1427075
doi:

Substances chimiques

Alkaloids 0
Calcium Channel Blockers 0
Calcium Channels, T-Type 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

17-24

Auteurs

Yu Zhu (Y)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
b University of the Chinese Academy of Sciences , Beijing 100049 , China.

Liao-Bin Dong (LB)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.

Zhi-Jun Zhang (ZJ)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
b University of the Chinese Academy of Sciences , Beijing 100049 , China.

Min Fan (M)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.

Qin-Feng Zhu (QF)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
b University of the Chinese Academy of Sciences , Beijing 100049 , China.

Yan-Yan Qi (YY)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
b University of the Chinese Academy of Sciences , Beijing 100049 , China.

Yu-Chen Liu (YC)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.
b University of the Chinese Academy of Sciences , Beijing 100049 , China.

Li-Yan Peng (LY)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.

Xing-De Wu (XD)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.

Qin-Shi Zhao (QS)

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204 , China.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Three new Lycopodium alkaloids from Lycopodium...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux calciques › Three new Lycopodium alkaloids from Lycopodium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type T › Three new Lycopodium alkaloids from Lycopodium...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Three new Lycopodium alkaloids from Lycopodium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Three new Lycopodium alkaloids from Lycopodium...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Lycopodiaceae › Lycopodium › Three new Lycopodium alkaloids from Lycopodium...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Three new Lycopodium alkaloids from Lycopodium...