Blood-based biomarkers predicting response to antidepressants.
5-HTT
Antidepressants
BDNF
Biomarkers
FKBP5
Genetic variants
HPA axis
Immune
Inflammation
Major depression
SNPs
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
17
12
2017
accepted:
11
01
2018
pubmed:
29
1
2018
medline:
13
6
2020
entrez:
29
1
2018
Statut:
ppublish
Résumé
Major depressive disorder is a common, serious and in some cases, life-threatening condition and affects approximately 350 million people globally. Although there is effective treatment available for it, more than 50% of the patients fail to respond to the first antidepressant they receive. The selection of a distinct treatment is still exclusively based on clinical judgment without incorporating lab-derived objective measures. However, there is growing evidence of biomarkers that it helps to improve diagnostic processes and treatment algorithms. Here genetic markers and blood-based biomarkers of the monoamine pathways, inflammatory pathways and the hypothalamic-pituitary-adrenal (HPA) axis are reviewed. Promising findings arise from studies investigating inflammatory pathways and immune markers that may identify patients suitable for anti-inflammatory based treatment regimes. Next, an early normalization of a disturbed HPA axis or depleted neurotrophic factors may predict stable treatment response. Genetic markers within the serotonergic system may identify patients who are vulnerable because of stressful life events, but evidence for guiding treatment regimes still is inconsistent. Therefore, there is still a great need for studies investigating and validating biomarkers for the prediction of treatment response to facilitate the treatment selection and shorten the time to remission and thus provide personalized medicine in psychiatry.
Identifiants
pubmed: 29374800
doi: 10.1007/s00702-018-1844-x
pii: 10.1007/s00702-018-1844-x
doi:
Substances chimiques
Antidepressive Agents
0
Biomarkers
0
Membrane Transport Proteins
0
Receptors, Neurotransmitter
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-63Références
Brain Behav Immun. 2015 Aug;48:8-18
pubmed: 25683698
PLoS One. 2008 Apr 02;3(4):e1872
pubmed: 18382661
Neuropsychobiology. 2007;56(4):167-71
pubmed: 18332644
Pharmacogenomics J. 2009 Aug;9(4):225-33
pubmed: 19365399
Psychoneuroendocrinology. 2013 Sep;38(9):1803-13
pubmed: 23571152
Transl Psychiatry. 2012 Dec 04;2:e199
pubmed: 23212583
JAMA Psychiatry. 2013 Jan;70(1):31-41
pubmed: 22945416
Int Rev Psychiatry. 2010;22(5):485-500
pubmed: 21047161
Psychiatr Genet. 2009 Dec;19(6):281-91
pubmed: 19829169
PLoS One. 2015 Jun 03;10(6):e0127550
pubmed: 26039142
Hum Genet. 1998 Sep;103(3):273-9
pubmed: 9799080
Biol Psychiatry. 2006 Apr 15;59(8):681-8
pubmed: 16580345
Mol Neurobiol. 2007 Feb;35(1):45-54
pubmed: 17519505
Am J Hum Genet. 2006 May;78(5):815-826
pubmed: 16642437
Pharmacol Rev. 1999 Dec;51(4):593-628
pubmed: 10581325
Neuropsychobiology. 2010;62(2):121-31
pubmed: 20588071
Am J Med Genet B Neuropsychiatr Genet. 2007 Apr 5;144B(3):325-31
pubmed: 17192957
Transl Psychiatry. 2017 Feb 21;7(2):e1042
pubmed: 28221367
Psychol Med. 2012 May;42(5):943-56
pubmed: 21995950
Biol Psychiatry. 2004 Jun 1;55(11):1090-4
pubmed: 15158428
J Psychopharmacol. 2010 Apr;24(4):625-6
pubmed: 19282426
Nat Genet. 2004 Dec;36(12):1319-25
pubmed: 15565110
Transl Psychiatry. 2015 Mar 31;5:e538
pubmed: 25826113
Science. 1996 Nov 29;274(5292):1527-31
pubmed: 8929413
Arch Gen Psychiatry. 1985 Dec;42(12):1193-204
pubmed: 3000317
J Affect Disord. 2011 Jan;128(1-2):41-8
pubmed: 20619899
Neurosci Lett. 2008 May 9;436(2):111-5
pubmed: 18387740
Eur Neuropsychopharmacol. 2012 Apr;22(4):239-58
pubmed: 22137564
Arch Gen Psychiatry. 2009 Sep;66(9):966-975
pubmed: 19736353
J Psychiatr Res. 2007 Apr-Jun;41(3-4):326-31
pubmed: 16870211
J Affect Disord. 2006 Feb;90(2-3):251-6
pubmed: 16356553
Ann Acad Med Singapore. 1985 Jan;14(1):104-9
pubmed: 4004115
Neuropsychobiology. 2010;61(2):71-8
pubmed: 20016225
J Psychiatry Neurosci. 2011 Mar;36(2):87-113
pubmed: 21172166
Biol Psychiatry. 2005 Sep 1;58(5):374-81
pubmed: 15993855
Mol Psychiatry. 2010 May;15(5):473-500
pubmed: 18982004
Front Cell Neurosci. 2014 Dec 22;8:430
pubmed: 25565964
Int Clin Psychopharmacol. 2007 May;22(3):137-43
pubmed: 17414739
Drug Alcohol Depend. 2013 Mar 1;128(3):175-86
pubmed: 23294766
Pharmacogenomics J. 2004;4(4):233-44
pubmed: 15111987
Am J Psychiatry. 2015 Aug 1;172(8):751-9
pubmed: 25815420
Am J Med Genet B Neuropsychiatr Genet. 2015 Jun;168B(4):274-83
pubmed: 25847751
J Neurosci Methods. 2004 Dec 30;140(1-2):133-9
pubmed: 15589343
FEBS Lett. 1999 Sep 17;458(2):171-4
pubmed: 10481059
J Psychiatr Res. 2001 Mar-Apr;35(2):83-94
pubmed: 11377437
Brain Behav Immun. 2016 Aug;56:96-104
pubmed: 26891860
Mol Psychiatry. 2004 Sep;9(9):879-89
pubmed: 15052272
Psychoneuroendocrinology. 2014 Jun;44:35-46
pubmed: 24767618
Neuropsychopharmacology. 2000 Nov;23(5):477-501
pubmed: 11027914
Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):115-23
pubmed: 18484082
Pharmacogenomics J. 2012 Feb;12(1):78-85
pubmed: 20877297
Eur Neuropsychopharmacol. 2013 Sep;23(9):1105-14
pubmed: 23142150
Int J Neuropsychopharmacol. 2010 May;13(4):535-9
pubmed: 19941699
Psychoneuroendocrinology. 2011 Apr;36(3):426-36
pubmed: 21041030
Arch Gen Psychiatry. 1983 May;40(5):493-500
pubmed: 6340634
Neurosci Biobehav Rev. 2015 Nov;58:63-78
pubmed: 26271720
Biol Psychiatry. 2001 Mar 1;49(5):391-404
pubmed: 11274650
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9950-5
pubmed: 23671070
J Affect Disord. 2012 Aug;139(3):230-9
pubmed: 21872339
Pharmacogenet Genomics. 2013 Jun;23(6):301-13
pubmed: 23619509
Mol Interv. 2004 Apr;4(2):109-23
pubmed: 15087484
Tissue Antigens. 2012 Aug;80(2):136-42
pubmed: 22571276
Ann N Y Acad Sci. 2006 Aug;1074:320-9
pubmed: 17105928
Neuropsychopharmacology. 2012 Jan;37(1):308-9
pubmed: 22157874
Int J Neuropsychopharmacol. 2009 Nov;12(10):1327-35
pubmed: 19573266
Am J Psychiatry. 2001 May;158(5):748-53
pubmed: 11329397
Nat Rev Neurosci. 2005 Jun;6(6):463-75
pubmed: 15891777
Science. 2003 Jul 18;301(5631):386-9
pubmed: 12869766
Int Clin Psychopharmacol. 2012 Nov;27(6):314-20
pubmed: 22890315
J Psychopharmacol. 2010 Dec;24(12):1747-54
pubmed: 20142305
J Affect Disord. 2009 Dec;119(1-3):107-15
pubmed: 19339052
Brain Behav Immun. 2008 May;22(4):493-502
pubmed: 18054198
Mol Psychiatry. 2012 Jun;17(6):612-23
pubmed: 21808255
Neuropsychobiology. 2006;53(4):186-95
pubmed: 16874005
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):224-8
pubmed: 17884271
Mol Psychiatry. 2013 Mar;18(3):332-9
pubmed: 22158016
Int J Neuropsychopharmacol. 2004 Dec;7(4):501-6
pubmed: 15447813
Am J Psychiatry. 2001 Jan;158(1):78-85
pubmed: 11136637
Neuropsychobiology. 2013;67(1):41-7
pubmed: 23221997
Hum Psychopharmacol. 2010 Apr;25(3):201-15
pubmed: 20373471
Biol Psychiatry. 2007 Aug 15;62(4):355-8
pubmed: 17141746
Arch Gen Psychiatry. 1999 Jan;56(1):39-44
pubmed: 9892254
Br J Pharmacol. 2007 Jul;151(6):737-48
pubmed: 17471183
Clin Ther. 2012 Jan;34(1):113-23
pubmed: 22177545
Eur Neuropsychopharmacol. 2006 Oct;16(7):498-503
pubmed: 16458487
World J Biol Psychiatry. 2008;9(3):190-7
pubmed: 17853254
Ther Drug Monit. 2004 Apr;26(2):180-5
pubmed: 15228162
Am J Psychiatry. 2014 Dec 1;171(12):1278-86
pubmed: 25017001
Mol Psychiatry. 2018 Jan;23(1):133-142
pubmed: 28373689
Am J Geriatr Psychiatry. 2014 Nov;22(11):1140-8
pubmed: 23973251
Biol Psychiatry. 2003 Nov 1;54(9):879-83
pubmed: 14573314
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404
pubmed: 17913323
Biol Psychiatry. 2010 Jan 15;67(2):133-8
pubmed: 19846067
J Affect Disord. 2015 Apr 1;175:233-40
pubmed: 25658497
Neuropharmacology. 1998 Dec;37(12):1553-61
pubmed: 9886678
Int J Psychiatry Med. 2007;37(3):315-29
pubmed: 18314859
Mol Psychiatry. 2014 Jul;19(7):750-1
pubmed: 24342989
Biol Psychiatry. 2010 Jun 1;67(11):1110-3
pubmed: 20110084
J Pharmacol Exp Ther. 2004 Nov;311(2):427-40
pubmed: 15297468
Biol Psychiatry. 2008 Apr 1;63(7):642-9
pubmed: 17981266
Eur Neuropsychopharmacol. 2015 Apr;25(4):441-53
pubmed: 25769916
Psychiatry Res. 2015 Aug 30;233(2):120-4
pubmed: 26078197
Pharmacogenomics J. 2006 Jan-Feb;6(1):27-33
pubmed: 16302021
Arch Gen Psychiatry. 2007 Jul;64(7):783-92
pubmed: 17606812
J Affect Disord. 2014 Oct;168:430-8
pubmed: 25108775
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1097-8
pubmed: 17721930
J Clin Psychiatry. 2001;62 Suppl 15:8-11
pubmed: 11444765
Int J Neuropsychopharmacol. 2010 Feb;13(1):103-8
pubmed: 19835669
Biol Psychiatry. 2010 Mar 15;67(6):543-9
pubmed: 20044070
Genes Brain Behav. 2013 Apr;12(3):289-96
pubmed: 23406438
Psychopharmacology (Berl). 2011 Feb;213(4):773-9
pubmed: 20945066
Pharmacogenet Genomics. 2010 Aug;20(8):467-75
pubmed: 20555295
Pharmacogenomics J. 2013 Aug;13(4):349-53
pubmed: 22641028
Genomics. 2007 Sep;90(3):397-406
pubmed: 17629449
Biol Psychiatry. 2010 Mar 1;67(5):446-57
pubmed: 20015486
Mol Psychiatry. 2009 Dec;14(12):1105-18
pubmed: 19844206
Arch Gen Psychiatry. 2004 Nov;61(11):1163-9
pubmed: 15520364
Int J Neuropsychopharmacol. 2002 Mar;5(1):27-35
pubmed: 12057029
Neuropsychopharmacology. 2011 Nov;36(12):2452-9
pubmed: 21796103
Int J Neuropsychopharmacol. 2004 Dec;7(4):453-60
pubmed: 15458611
Neuropsychopharmacology. 2018 Jan;43(1):227-228
pubmed: 29192656
Pharmacogenomics J. 2004;4(4):283-6
pubmed: 15148501
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):645-51
pubmed: 20227453
JAMA. 2006 Oct 4;296(13):1609-18
pubmed: 17018806
Biol Psychiatry. 2008 Jun 15;63(12):1103-10
pubmed: 18191112
Clin Chem. 2006 May;52(5):893-5
pubmed: 16638956
Neuron. 2008 Jan 24;57(2):203-9
pubmed: 18215618
Pharmacoepidemiol Drug Saf. 2008 Jul;17(7):697-706
pubmed: 18181227
J Neurol Neurosurg Psychiatry. 2012 May;83(5):495-502
pubmed: 22423117
Mol Psychiatry. 1997 Oct-Nov;2(6):457-62
pubmed: 9399688
J Affect Disord. 2007 Dec;104(1-3):83-90
pubmed: 17467808
J Neural Transm (Vienna). 2016 May;123(5):541-8
pubmed: 26821321
Pharmacopsychiatry. 2012 May;45(3):108-13
pubmed: 22086748
Am J Psychiatry. 2004 Sep;161(9):1575-80
pubmed: 15337646
Psychopharmacology (Berl). 2009 Aug;205(3):409-17
pubmed: 19468717
Mol Psychiatry. 1998 Jan;3(1):42-9
pubmed: 9491812
Neuropsychopharmacology. 2010 Jun;35(7):1423-8
pubmed: 20164831
Behav Brain Funct. 2006 Jul 05;2:24
pubmed: 16822313
Biol Psychiatry. 2007 Mar 15;61(6):734-42
pubmed: 17123473
Am J Psychiatry. 2010 May;167(5):555-64
pubmed: 20360315
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:183-94
pubmed: 23733030
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15251-5
pubmed: 10611371
Neuropsychopharmacology. 2012 May;37(6):1455-64
pubmed: 22237309
J Psychiatr Res. 1994 Jul-Aug;28(4):341-56
pubmed: 7877114
Eur Neuropsychopharmacol. 2001 Oct;11(5):375-80
pubmed: 11597824
Lancet. 1996 Mar 16;347(9003):731-3
pubmed: 8602004
Neuroreport. 2000 Jan 17;11(1):215-9
pubmed: 10683861
Annu Rev Neurosci. 1999;22:197-217
pubmed: 10202537
J Affect Disord. 2018 Jan 15;226:339-345
pubmed: 29031184
Psychoneuroendocrinology. 2016 Jul;69:161-71
pubmed: 27107207
Neuropsychopharmacology. 2000 Apr;22(4):370-9
pubmed: 10700656
Neuropsychopharmacology. 2013 Feb;38(3):377-85
pubmed: 22990943
Mol Psychiatry. 2011 May;16(5):516-32
pubmed: 20351714
Hum Psychopharmacol. 2008 Mar;23(2):121-8
pubmed: 18023073
Biol Psychiatry. 2006 Apr 15;59(8):689-95
pubmed: 16458268
Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):93-103
pubmed: 15666411
Transl Psychiatry. 2014 Sep 16;4:e442
pubmed: 25226551
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9262-7
pubmed: 21518864
J Affect Disord. 2015 Sep 15;184:239-44
pubmed: 26117067
Psychiatry Res. 2012 Dec 30;200(2-3):1047-50
pubmed: 22796099
Mol Psychiatry. 2010 Aug;15(8):784-6
pubmed: 20351717
Psychiatr Genet. 2008 Oct;18(5):248-51
pubmed: 18797399
Biol Psychiatry. 2006 Apr 15;59(8):696-701
pubmed: 16368077
Curr Drug Targets Inflamm Allergy. 2004 Dec;3(4):395-412
pubmed: 15584888
Neuropsychopharmacology. 2006 Aug;31(8):1745-9
pubmed: 16395308
Psychopharmacology (Berl). 2001 Feb;154(1):70-5
pubmed: 11292008
Mol Psychiatry. 2015 Aug;20(8):916-30
pubmed: 25824305
Pharmacogenomics J. 2015 Aug;15(4):332-9
pubmed: 25487678
Transl Psychiatry. 2012 Apr 17;2:e101
pubmed: 22832901
J Neuroendocrinol. 1989 Dec 1;1(6):485-8
pubmed: 19210420
Pharmacogenomics J. 2005;5(1):49-53
pubmed: 15520843
Biol Psychiatry. 2007 Jul 1;62(1):47-54
pubmed: 17123470
Eur Neuropsychopharmacol. 2009 Jun;19(6):451-6
pubmed: 19272758
Brain Res Mol Brain Res. 1997 Apr;45(1):145-8
pubmed: 9105682
Pharmacogenomics J. 2007 Feb;7(1):48-55
pubmed: 16702979
Pharmacogenet Genomics. 2009 Jan;19(1):67-76
pubmed: 18987562
Am J Med Genet. 2000 Dec 4;96(6):831-5
pubmed: 11121191
Am J Med Genet B Neuropsychiatr Genet. 2013 Sep;162B(6):487-520
pubmed: 23852853
Eur Neuropsychopharmacol. 2008 Mar;18(3):230-3
pubmed: 17681762
JAMA Psychiatry. 2014 Dec 1;71(12):1381-91
pubmed: 25322082
Biol Psychiatry. 2007 Jan 15;61(2):167-73
pubmed: 16697352
Mol Pharmacol. 2005 Aug;68(2):457-66
pubmed: 15894713
Eur J Pharmacol. 2008 Apr 7;583(2-3):350-7
pubmed: 18272149
Arch Gen Psychiatry. 1981 Jan;38(1):15-22
pubmed: 7458567
Pharmacol Biochem Behav. 2010 Jan;94(3):363-73
pubmed: 19800913
Mol Psychiatry. 2004 Dec;9(12):1075-82
pubmed: 15365580
Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S186-95
pubmed: 19560279
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):445-50
pubmed: 17976882
J Affect Disord. 2005 Aug;87(2-3):305-11
pubmed: 15951024
Neuroreport. 2009 Aug 5;20(12):1125-8
pubmed: 19590397