Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?
Cardio-oncology
Chemotherapy
Genomics
Induced pluripotent stem cells
Precision medicine
Journal
European heart journal
ISSN: 1522-9645
Titre abrégé: Eur Heart J
Pays: England
ID NLM: 8006263
Informations de publication
Date de publication:
07 06 2019
07 06 2019
Historique:
received:
23
06
2017
revised:
12
10
2017
accepted:
22
12
2017
pubmed:
30
1
2018
medline:
30
9
2020
entrez:
30
1
2018
Statut:
ppublish
Résumé
Cardiotoxic effects from cancer therapy are a major cause of morbidity during cancer treatment. Unexpected toxicity can occur during treatment and/or after completion of therapy, into the time of cancer survivorship. While older drugs such as anthracyclines have well-known cardiotoxic effects, newer drugs such as tyrosine kinase inhibitors, proteasome inhibitors, and immunotherapies also can cause diverse cardiovascular and metabolic complications. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly being used as instruments for disease modelling, drug discovery, and mechanistic toxicity studies. Promising results with hiPSC-CM chemotherapy studies are raising hopes for improving cancer therapies through personalized medicine and safer drug development. Here, we review the cardiotoxicity profiles of common chemotherapeutic agents as well as efforts to model them in vitro using hiPSC-CMs.
Identifiants
pubmed: 29377985
pii: 4825036
doi: 10.1093/eurheartj/ehx811
pmc: PMC6554650
doi:
Substances chimiques
Antineoplastic Agents
0
Cardiotoxins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1764-1770Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL113006
Pays : United States
Organisme : NIH HHS
ID : T32 OD011121
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123968
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL135455
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 13SDG17340025
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126527
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132875
Pays : United States
Informations de copyright
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.
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