Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA.

2,2'-Dipyridyl / chemistry Click Chemistry Crystallography, X-Ray DNA / chemistry Ions Ligands Metals / chemistry Molecular Dynamics Simulation Molecular Weight Nucleic Acid Denaturation Nucleic Acid Heteroduplexes / chemistry Oligonucleotides / chemistry Temperature
DNA material DNA scaffold click reaction metallic DNA propargyl-DNA

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
Feb 2019
Historique:
pubmed: 16 2 2018
medline: 4 9 2019
entrez: 16 2 2018
Statut: ppublish

Résumé

The facile construction of metal-DNA complexes using 'Click' reactions is reported here. A series of 2'-propargyl-modified DNA oligonucleotides were initially synthesized as structure scaffolds and were then modified through 'Click' reaction to incorporate a bipyridine ligand equipped with an azido group. These metal chelating ligands can be placed in the DNA context in site-specific fashion to provide versatile templates for binding various metal ions, which are exchangeable using a simple EDTA washing-and-filtration step. The constructed metal-DNA complexes were found to be thermally stable. Their structures were explored by solving a crystal structure of a propargyl-modified DNA duplex and installing the bipyridine ligands by molecular modeling and simulation. These metal-DNA complexes could have wide applications as novel organometallic catalysts, artificial ribonucleases, and potential metal delivery systems.

Identifiants

DOI: 10.1080/07391102.2018.1441071 PMID: 29447072 PMC: PMC6715418
pubmed: 29447072
doi: 10.1080/07391102.2018.1441071
pmc: PMC6715418
mid: NIHMS1045072
doi:

Substances chimiques

Ions 0
Ligands 0
Metals 0
Nucleic Acid Heteroduplexes 0
Oligonucleotides 0
2,2'-Dipyridyl 551W113ZEP
DNA 9007-49-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

551-561

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM064328
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM121844
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM124627
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS063871
Pays : United States

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Auteurs

Rui Wang (R)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Srivathsan V Ranganathan (SV)

b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Phensinee Haruehanroengra (P)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Song Mao (S)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Matteo Scalabrin (M)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Daniele Fabris (D)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Alan Chen (A)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

Hehua Liu (H)

c State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences , Fudan University , Shanghai 200433 , China.

Abdalla E A Hassan (AEA)

d Applied Nucleic Acids Research Center, Faculty of Science , Zagazig University , Zagazig , Egypt.

Jianhua Gan (J)

c State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences , Fudan University , Shanghai 200433 , China.

Jia Sheng (J)

a Department of Chemistry , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.
b The RNA Institute , University at Albany, State University of New York , 1400 Washington Ave., Albany , NY 12222 , USA.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › 2,2'-Bipyridine › Construction and structure studies of...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Chimie click › Construction and structure studies of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Construction and structure studies of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Construction and structure studies of...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Construction and structure studies of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Construction and structure studies of...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Construction and structure studies of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Construction and structure studies of...
questionsmedicales.fr › Phénomènes chimiques › Masse moléculaire › Construction and structure studies of...
questionsmedicales.fr › Phénomènes génétiques › Dénaturation d'acide nucléique › Construction and structure studies of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › Hétéroduplexes d'acides nucléiques › Construction and structure studies of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Construction and structure studies of...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Construction and structure studies of...