Pharmacokinetics and brain penetration study of chlorogenic acid in rats.

Administration, Intranasal Animals Blood-Brain Barrier Brain / metabolism Cerebrospinal Fluid / chemistry Chlorogenic Acid / administration & dosage Chromatography, High Pressure Liquid Male Neuroprotective Agents / administration & dosage Plasma / chemistry Rats
Brain penetration CSF chlorogenic acid intranasal intravenous pharmacokinetics

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Mar 2019
Historique:
pubmed: 27 2 2018
medline: 2 5 2019
entrez: 27 2 2018
Statut: ppublish

Résumé

1. The present study is designed to investigate the brain distribution and plasma pharmacokinetics profiles of chlorogenic acid (CGA) after intranasal administration in Charles-Foster rats to evaluate whether the CGA molecules are transported directly via the nose-to-brain path. 2. The CGA is administered intravenously (IV) and intranasally (IN) at the dose of 10 mg/kg. Further, its concentration in the plasma, cerebrospinal fluid (CSF) and the whole brain is analyzed by HPLC-UV method. 3. The study observes that CGA is rapidly absorbed in plasma with t

Identifiants

DOI: 10.1080/00498254.2018.1445882 PMID: 29480050
pubmed: 29480050
doi: 10.1080/00498254.2018.1445882
doi:

Substances chimiques

Neuroprotective Agents 0
Chlorogenic Acid 318ADP12RI

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

339-345

Auteurs

Gaurav Kumar (G)

a School of Biomedical Engineering , Indian Institute of Technology, Banaras Hindu University , Varanasi , India.
ORCID: 0000-0003-2823-8419

Pankaj Paliwal (P)

b Department of Pharmaceutical Engineering and Technology , Indian Institute of Technology, Banaras Hindu University , Varanasi , India.
ORCID: 0000-0002-0918-4374

Sumedha Mukherjee (S)

a School of Biomedical Engineering , Indian Institute of Technology, Banaras Hindu University , Varanasi , India.

Nishant Patnaik (N)

c Neurochemistryblog.com , Banaras Hindu University , Varanasi , India.

Sairam Krishnamurthy (S)

b Department of Pharmaceutical Engineering and Technology , Indian Institute of Technology, Banaras Hindu University , Varanasi , India.

Ranjana Patnaik (R)

a School of Biomedical Engineering , Indian Institute of Technology, Banaras Hindu University , Varanasi , India.
ORCID: 0000-0002-8131-177X

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie muqueuse › Administration par voie nasale › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Eucaryotes › Animaux › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Liquide cérébrospinal › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acide chlorogénique › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Pharmacokinetics and brain penetration study...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Pharmacokinetics and brain penetration study...