Eicosanoids in the gastrointestinal tract.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
11
2017
revised:
06
02
2018
accepted:
09
02
2018
pubmed:
28
2
2018
medline:
4
7
2020
entrez:
28
2
2018
Statut:
ppublish
Résumé
Eicosanoids play important roles in modulating inflammation throughout the body. The gastrointestinal (GI) tract, in part because of its intimate relationship with the gut microbiota, is in a constant state of low-grade inflammation. Eicosanoids like PGs, lipoxins and leukotrienes play essential roles in maintenance of mucosal integrity. On the other hand, in some circumstances, these mediators can become major drivers of inflammatory processes when the lining of the GI tract is breached. Drugs such as nonsteroidal anti-inflammatories, by altering the production of various eicosanoids, can dramatically impact the ability of the GI tract to respond appropriately to injury. Disorders such as inflammatory bowel disease appear to be driven in part by altered production of eicosanoids. Several classes of drugs have been developed that target eicosanoids. LINKED ARTICLES: This article is part of a themed section on Eicosanoids 35 years from the 1982 Nobel: where are we now? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc.
Identifiants
pubmed: 29485681
doi: 10.1111/bph.14178
pmc: PMC6451073
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Eicosanoids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1000-1008Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2018 The British Pharmacological Society.
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