Titre : Médiateurs de l'inflammation

Médiateurs de l'inflammation : Questions médicales fréquentes

Nom anglais: Inflammation Mediators

Descriptor UI: D018836

Tree Number: D23.469

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une inflammation aiguë ?

Un examen clinique, des analyses sanguines et des imageries peuvent aider au diagnostic.
Inflammation Diagnostic médical
#2

Quels tests mesurent les médiateurs de l'inflammation ?

Des tests sanguins comme la CRP et la vitesse de sédimentation mesurent l'inflammation.
Médiateurs de l'inflammation Tests de laboratoire
#3

Quels signes indiquent une inflammation chronique ?

Fatigue, douleurs persistantes et symptômes systémiques peuvent indiquer une inflammation chronique.
Inflammation chronique Symptômes
#4

Comment évaluer l'activité inflammatoire ?

L'évaluation se fait par des biomarqueurs et des examens d'imagerie ciblés.
Biomarqueurs Imagerie médicale
#5

Quel rôle joue l'historique médical dans le diagnostic ?

L'historique médical aide à identifier des maladies sous-jacentes et des facteurs de risque.
Historique médical Facteurs de risque

Symptômes 5

#1

Quels sont les symptômes courants de l'inflammation ?

Rougeur, chaleur, gonflement, douleur et perte de fonction sont des symptômes typiques.
Symptômes Inflammation
#2

Comment l'inflammation affecte-t-elle le corps ?

Elle peut provoquer des douleurs, des dysfonctionnements organiques et des symptômes systémiques.
Inflammation Dysfonctionnement organique
#3

Quels symptômes indiquent une réaction allergique ?

Démangeaisons, éruptions cutanées et œdème peuvent signaler une réaction allergique inflammatoire.
Réaction allergique Inflammation
#4

L'inflammation peut-elle causer de la fièvre ?

Oui, l'inflammation peut entraîner une élévation de la température corporelle.
Fièvre Inflammation
#5

Quels symptômes sont associés à l'inflammation des articulations ?

Douleur, raideur et gonflement des articulations sont des symptômes fréquents.
Arthrite Inflammation

Prévention 5

#1

Comment prévenir l'inflammation chronique ?

Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, aide à prévenir l'inflammation.
Prévention Mode de vie sain
#2

Quels aliments sont anti-inflammatoires ?

Les fruits, légumes, noix et poissons gras sont connus pour leurs propriétés anti-inflammatoires.
Alimentation Propriétés anti-inflammatoires
#3

Le stress influence-t-il l'inflammation ?

Oui, le stress chronique peut exacerber l'inflammation et affecter la santé globale.
Stress Inflammation
#4

Comment le sommeil affecte-t-il l'inflammation ?

Un sommeil insuffisant peut augmenter les niveaux d'inflammation dans le corps.
Sommeil Inflammation
#5

L'hydratation joue-t-elle un rôle dans la prévention ?

Oui, une bonne hydratation aide à maintenir l'équilibre et à réduire l'inflammation.
Hydratation Prévention

Traitements 5

#1

Quels médicaments sont utilisés pour traiter l'inflammation ?

Les anti-inflammatoires non stéroïdiens (AINS) et les corticostéroïdes sont couramment prescrits.
Anti-inflammatoires Corticostéroïdes
#2

Comment les traitements biologiques agissent-ils ?

Ils ciblent des médiateurs spécifiques de l'inflammation pour réduire la réponse immunitaire.
Traitements biologiques Médiateurs de l'inflammation
#3

Quelles thérapies complémentaires peuvent aider ?

L'acupuncture, la physiothérapie et les régimes anti-inflammatoires peuvent être bénéfiques.
Thérapies complémentaires Régime alimentaire
#4

Quel rôle joue la rééducation dans le traitement ?

La rééducation aide à restaurer la fonction et à réduire la douleur après une inflammation.
Rééducation Douleur
#5

Les antibiotiques sont-ils efficaces contre l'inflammation ?

Non, les antibiotiques ne traitent pas l'inflammation sauf si une infection bactérienne est présente.
Antibiotiques Infection bactérienne

Complications 5

#1

Quelles sont les complications de l'inflammation chronique ?

Elle peut entraîner des maladies cardiovasculaires, diabète et troubles auto-immuns.
Complications Maladies chroniques
#2

L'inflammation peut-elle causer des dommages aux organes ?

Oui, une inflammation prolongée peut endommager les tissus et les organes affectés.
Dommages aux organes Inflammation
#3

Quels risques sont associés à l'inflammation des voies respiratoires ?

Elle peut aggraver l'asthme et provoquer des infections respiratoires récurrentes.
Voies respiratoires Asthme
#4

Comment l'inflammation affecte-t-elle le système immunitaire ?

Une inflammation chronique peut affaiblir le système immunitaire et augmenter les infections.
Système immunitaire Inflammation chronique
#5

L'inflammation est-elle liée au cancer ?

Oui, l'inflammation chronique est un facteur de risque pour certains types de cancer.
Cancer Inflammation chronique

Facteurs de risque 5

#1

Quels sont les principaux facteurs de risque d'inflammation ?

Obésité, tabagisme, sédentarité et alimentation déséquilibrée sont des facteurs clés.
Facteurs de risque Obésité
#2

L'âge influence-t-il l'inflammation ?

Oui, le vieillissement est associé à une augmentation des niveaux d'inflammation.
Âge Inflammation
#3

Les maladies auto-immunes augmentent-elles le risque d'inflammation ?

Oui, elles provoquent une réponse inflammatoire chronique dans le corps.
Maladies auto-immunes Inflammation
#4

Le manque d'exercice est-il un facteur de risque ?

Oui, un mode de vie sédentaire contribue à l'inflammation et à des maladies associées.
Sédentarité Inflammation
#5

Le stress psychologique influence-t-il l'inflammation ?

Oui, le stress peut déclencher des réponses inflammatoires dans le corps.
Stress Inflammation
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"@type": "Answer", "text": "L'évaluation se fait par des biomarqueurs et des examens d'imagerie ciblés." } }, { "@type": "Question", "name": "Quel rôle joue l'historique médical dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'historique médical aide à identifier des maladies sous-jacentes et des facteurs de risque." } }, { "@type": "Question", "name": "Quels sont les symptômes courants de l'inflammation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Rougeur, chaleur, gonflement, douleur et perte de fonction sont des symptômes typiques." } }, { "@type": "Question", "name": "Comment l'inflammation affecte-t-elle le corps ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut provoquer des douleurs, des dysfonctionnements organiques et des symptômes systémiques." } }, { "@type": "Question", "name": "Quels symptômes indiquent une réaction allergique ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Démangeaisons, éruptions cutanées et œdème peuvent signaler une réaction allergique inflammatoire." } }, { "@type": "Question", "name": "L'inflammation peut-elle causer de la fièvre ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'inflammation peut entraîner une élévation de la température corporelle." } }, { "@type": "Question", "name": "Quels symptômes sont associés à l'inflammation des articulations ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Douleur, raideur et gonflement des articulations sont des symptômes fréquents." } }, { "@type": "Question", "name": "Comment prévenir l'inflammation chronique ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, aide à prévenir l'inflammation." } }, { "@type": "Question", "name": "Quels aliments sont anti-inflammatoires ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Les fruits, légumes, noix et poissons gras sont connus pour leurs propriétés anti-inflammatoires." } }, { "@type": "Question", "name": "Le stress influence-t-il l'inflammation ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut exacerber l'inflammation et affecter la santé globale." } }, { "@type": "Question", "name": "Comment le sommeil affecte-t-il l'inflammation ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Un sommeil insuffisant peut augmenter les niveaux d'inflammation dans le corps." } }, { "@type": "Question", "name": "L'hydratation joue-t-elle un rôle dans la prévention ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une bonne hydratation aide à maintenir l'équilibre et à réduire l'inflammation." } }, { "@type": "Question", "name": "Quels médicaments sont utilisés pour traiter l'inflammation ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les anti-inflammatoires non stéroïdiens (AINS) et les corticostéroïdes sont couramment prescrits." } }, { "@type": "Question", "name": "Comment les traitements biologiques agissent-ils ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Ils ciblent des médiateurs spécifiques de l'inflammation pour réduire la réponse immunitaire." } }, { "@type": "Question", "name": "Quelles thérapies complémentaires peuvent aider ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "L'acupuncture, la physiothérapie et les régimes anti-inflammatoires peuvent être bénéfiques." } }, { "@type": "Question", "name": "Quel rôle joue la rééducation dans le traitement ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "La rééducation aide à restaurer la fonction et à réduire la douleur après une inflammation." } }, { "@type": "Question", "name": "Les antibiotiques sont-ils efficaces contre l'inflammation ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Non, les antibiotiques ne traitent pas l'inflammation sauf si une infection bactérienne est présente." } }, { "@type": "Question", "name": "Quelles sont les complications de l'inflammation chronique ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut entraîner des maladies cardiovasculaires, diabète et troubles auto-immuns." } }, { "@type": "Question", "name": "L'inflammation peut-elle causer des dommages aux organes ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une inflammation prolongée peut endommager les tissus et les organes affectés." } }, { "@type": "Question", "name": "Quels risques sont associés à l'inflammation des voies respiratoires ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut aggraver l'asthme et provoquer des infections respiratoires récurrentes." } }, { "@type": "Question", "name": "Comment l'inflammation affecte-t-elle le système immunitaire ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Une inflammation chronique peut affaiblir le système immunitaire et augmenter les infections." } }, { "@type": "Question", "name": "L'inflammation est-elle liée au cancer ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'inflammation chronique est un facteur de risque pour certains types de cancer." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque d'inflammation ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Obésité, tabagisme, sédentarité et alimentation déséquilibrée sont des facteurs clés." } }, { "@type": "Question", "name": "L'âge influence-t-il l'inflammation ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le vieillissement est associé à une augmentation des niveaux d'inflammation." } }, { "@type": "Question", "name": "Les maladies auto-immunes augmentent-elles le risque d'inflammation ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles provoquent une réponse inflammatoire chronique dans le corps." } }, { "@type": "Question", "name": "Le manque d'exercice est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire contribue à l'inflammation et à des maladies associées." } }, { "@type": "Question", "name": "Le stress psychologique influence-t-il l'inflammation ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress peut déclencher des réponses inflammatoires dans le corps." } } ] } ] }
Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

Validation scientifique effectuée le 16/04/2026

Contenu vérifié selon les dernières recommandations médicales

En savoir plus sur Dr Menir

Sous-catégories

56 au total
└─

Alarmines

Alarmins D000067531 - D23.469.025
└─

Autacoïdes

Autacoids D012898 - D23.469.050
└─

Prostaglandines synthétiques

Prostaglandins, Synthetic D011465 - D23.469.700
└─

Récepteur spécifique des produits finaux de glycosylation avancée

Receptor for Advanced Glycation End Products D000067759 - D23.469.850
└─└─

Angiotensines

Angiotensins D000809 - D23.469.050.050
└─└─

Éicosanoïdes

Eicosanoids D015777 - D23.469.050.175
└─└─

Histamine

Histamine D006632 - D23.469.050.300
└─└─

Facteur d'activation plaquettaire

Platelet Activating Factor D010972 - D23.469.050.600
└─└─

Sérotonine

Serotonin D012701 - D23.469.050.650
└─└─

Iloprost

Iloprost D016285 - D23.469.700.275
└─└─

Prostaglandines endoperoxydes synthétiques

Prostaglandin Endoperoxides, Synthetic D011450 - D23.469.700.630
└─└─

Prostaglandines A synthétiques

Prostaglandins A, Synthetic D011455 - D23.469.700.645
└─└─

Prostaglandines E synthétiques

Prostaglandins E, Synthetic D011459 - D23.469.700.660
└─└─

Prostaglandines F synthétiques

Prostaglandins F, Synthetic D011461 - D23.469.700.670
└─└─└─

Angiotensine-I

Angiotensin I D000803 - D23.469.050.050.025
└─└─└─

Angiotensine-II

Angiotensin II D000804 - D23.469.050.050.050
└─└─└─

Angiotensine-III

Angiotensin III D000805 - D23.469.050.050.075
└─└─└─

Leucotriènes

Leukotrienes D015289 - D23.469.050.175.450
└─└─└─

Prostaglandines

Prostaglandins D011453 - D23.469.050.175.725
└─└─└─

Urotensines

Urotensins D014579 - D23.469.050.375.925
└─└─└─

Acide 15-hydroxy-11alpha,9alpha-(époxyméthano)prosta-5,13-diénoïque

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid D019796 - D23.469.700.630.500
└─└─└─

Arbaprostil

Arbaprostil D001101 - D23.469.700.660.050
└─└─└─

Diméthyl-16,16 prostaglandine E2

16,16-Dimethylprostaglandin E2 D015064 - D23.469.700.660.200
└─└─└─

Enprostil

Enprostil D016620 - D23.469.700.660.250
└─└─└─

Misoprostol

Misoprostol D016595 - D23.469.700.660.500
└─└─└─

Rioprostil

Rioprostil D016630 - D23.469.700.660.750
└─└─└─

Carboprost

Carboprost D002260 - D23.469.700.670.150
└─└─└─

Cloprosténol

Cloprostenol D003008 - D23.469.700.670.175
└─└─└─

Latanoprost

Latanoprost D000077338 - D23.469.700.670.587
└─└─└─└─

Angiotensinamide

Angiotensin Amide D000802 - D23.469.050.050.050.050
└─└─└─└─

Saralasine

Saralasin D012504 - D23.469.050.050.050.700
└─└─└─└─

1-Sarcosyl-8-isoleucyl-angiotensine-II

1-Sarcosine-8-Isoleucine Angiotensin II D015059 - D23.469.050.050.050.725
└─└─└─└─

Leucotriène A4

Leukotriene A4 D017572 - D23.469.050.175.450.400
└─└─└─└─

Leucotriène B4

Leukotriene B4 D007975 - D23.469.050.175.450.415
└─└─└─└─

Substances à réaction différée de l'anaphylaxie

SRS-A D013189 - D23.469.050.175.450.725
└─└─└─└─

Prostaglandines endoperoxydes

Prostaglandin Endoperoxides D011449 - D23.469.050.175.725.025
└─└─└─└─

Prostaglandines A

Prostaglandins A D011454 - D23.469.050.175.725.100
└─└─└─└─

Prostaglandines B

Prostaglandins B D011456 - D23.469.050.175.725.150
└─└─└─└─

Prostaglandines D

Prostaglandins D D011457 - D23.469.050.175.725.200
└─└─└─└─

Prostaglandines E

Prostaglandins E D011458 - D23.469.050.175.725.250
└─└─└─└─

Prostaglandines F

Prostaglandins F D011460 - D23.469.050.175.725.400
└─└─└─└─

Prostaglandines I

Prostaglandins I D044062 - D23.469.050.175.725.550
└─└─└─└─

Bimatoprost

Bimatoprost D000069580 - D23.469.700.670.175.250
└─└─└─└─

Travoprost

Travoprost D000069557 - D23.469.700.670.175.500
└─└─└─└─└─

Leucotriène C4

Leukotriene C4 D017997 - D23.469.050.175.450.725.400
└─└─└─└─└─

Leucotriène D4

Leukotriene D4 D017998 - D23.469.050.175.450.725.415
└─└─└─└─└─

Leucotriène E4

Leukotriene E4 D017999 - D23.469.050.175.450.725.425
└─└─└─└─└─

Prostaglandines G

Prostaglandins G D011462 - D23.469.050.175.725.025.600
└─└─└─└─└─

Prostaglandines H

Prostaglandins H D011463 - D23.469.050.175.725.025.650
└─└─└─└─└─

Prostaglandine D2

Prostaglandin D2 D015230 - D23.469.050.175.725.200.200
└─└─└─└─└─

Alprostadil

Alprostadil D000527 - D23.469.050.175.725.250.100
└─└─└─└─└─

Dinoprostone

Dinoprostone D015232 - D23.469.050.175.725.250.200
└─└─└─└─└─

Dinoprost

Dinoprost D015237 - D23.469.050.175.725.400.200
└─└─└─└─└─

6-Cétoprostaglandine Fl alpha

6-Ketoprostaglandin F1 alpha D015121 - D23.469.050.175.725.400.350
└─└─└─└─└─

Prostacycline

Epoprostenol D011464 - D23.469.050.175.725.550.500
└─└─└─└─└─└─

Prostaglandine H2

Prostaglandin H2 D044262 - D23.469.050.175.725.025.650.500

Auteurs principaux

A Klímová

4 publications dans cette catégorie

Publications dans "Médiateurs de l'inflammation" :

M Brichová

4 publications dans cette catégorie

Publications dans "Médiateurs de l'inflammation" :

E Říhová

4 publications dans cette catégorie

Publications dans "Médiateurs de l'inflammation" :

J Heissigerová

4 publications dans cette catégorie

Publications dans "Médiateurs de l'inflammation" :

P Svozílková

4 publications dans cette catégorie

Publications dans "Médiateurs de l'inflammation" :

Daniel W Trott

1 publication dans cette catégorie

Affiliations :
  • Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
Publications dans "Médiateurs de l'inflammation" :

Paul J Fadel

1 publication dans cette catégorie

Affiliations :
  • Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
Publications dans "Médiateurs de l'inflammation" :

Mandy M T van Leent

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Experimetal Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands.
Publications dans "Médiateurs de l'inflammation" :

Thijs J Beldman

1 publication dans cette catégorie

Affiliations :
  • Experimetal Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands.
  • Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Publications dans "Médiateurs de l'inflammation" :

Yohana C Toner

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Publications dans "Médiateurs de l'inflammation" :

Marnix A Lameijer

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Experimetal Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands.
Publications dans "Médiateurs de l'inflammation" :

Nils Rother

1 publication dans cette catégorie

Affiliations :
  • Department of Nephrology and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Publications dans "Médiateurs de l'inflammation" :

Siroon Bekkering

1 publication dans cette catégorie

Affiliations :
  • Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Publications dans "Médiateurs de l'inflammation" :

Abraham J P Teunissen

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Publications dans "Médiateurs de l'inflammation" :

Xianxiao Zhou

1 publication dans cette catégorie

Affiliations :
  • Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Publications dans "Médiateurs de l'inflammation" :

Roy van der Meel

1 publication dans cette catégorie

Affiliations :
  • Department of Chemical Biology, Eindhoven University of Technology, 5612 AZ Eindhoven, Netherlands.
Publications dans "Médiateurs de l'inflammation" :

Joost Malkus

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Publications dans "Médiateurs de l'inflammation" :

Sheqouia A Nauta

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Publications dans "Médiateurs de l'inflammation" :

Emma D Klein

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Publications dans "Médiateurs de l'inflammation" :

Francois Fay

1 publication dans cette catégorie

Affiliations :
  • Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Institut Galien Paris-Saclay, Faculté de Pharmacie, CNRS, Université Paris-Saclay, 92 296 Châtenay-Malabry, France.
Publications dans "Médiateurs de l'inflammation" :

Sources (10000 au total)

Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review).

Jun 2024
DOI: 10.3892/mmr.2024.13219 PMID: 38606791

Obesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular ...

Humans Obesity Metabolic Syndrome Inflammation Insulin Resistance +4 autres

Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus.

2024
DOI: 10.3389/fimmu.2024.1381319 PMID: 38742118

Inflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eve... Here, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment.... We identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types.... Overall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and activation, which are key steps in the pathophysiol...

Humans Pancreatic Ducts Single-Cell Analysis Transcriptome Inflammation +4 autres

Aggregatibacter is inversely associated with inflammatory mediators in sputa of patients with chronic airway diseases and reduces inflammation in vitro.

12 Oct 2024
DOI: 10.1186/s12931-024-02983-z PMID: 39395980

Chronic airway disease (CAD) is characterized by chronic airway inflammation and colonization of the lungs by pro-inflammatory pathogens. However, while various other bacterial species are present in ... Paired sputum microbiome and inflammatory marker data of adults with CAD across three separate cohorts (Australian asthma and bronchiectasis, Scottish bronchiectasis) was analyzed using Linear discrim... We identified the genus Aggregatibacter as more abundant in patients with lower levels of airway inflammatory markers in two CAD cohorts (Australian asthma and bronchiectasis). In addition, the relati... These findings suggest that Aggregatibacter spp. might act to reduce airway inflammation in CAD patients....

Humans Sputum Female Male Middle Aged +8 autres

Ocular surface inflammation and ectatic corneal disorders.

01 10 2023
DOI: 10.1097/ACI.0000000000000935 PMID: 37490610

Inflammatory mediators are a focus of recent corneal ectasia (CE) research and are a profound, modifiable contributor to CE in general and keratoconus (KC) in particular, opening a path to explore new... Significant increases in the inflammatory mediators and immune components have been observed in the cornea, tear fluid, and blood of ectasia patients, while inflammation dampeners such as vitamin D an... Strategies such as monitoring inflammatory factors and using immune or inflammatory modulators, including managing subclinical inflammation, may be clinically beneficial in stabilizing the disease and...

Humans Dilatation, Pathologic Cornea Keratoconus Inflammation +3 autres

Systemic inflammation biomarkers during angioedema attacks in hereditary angioedema.

2024
DOI: 10.3389/fimmu.2024.1400526 PMID: 38953032

Hereditary angioedema (HAE) is a rare disease characterized by localized and self-limited angioedema (AE) attacks. A local increase of bradykinin (BK) mediates AE attacks in HAE, however the role of i... Patients with a confirmed HAE diagnosis due to C1 inhibitor deficiency (HAE-C1INH) or patients... Seventy-eight patients were enrolled in the study, with a predominant representation of women (76%, n=59), and a mean age of 47.8 years (range 6-88). Among them, 67% (n=52) of patients had HAE-C1INH (... The systemic increase in APR observed during HAE attacks suggests that inflammation extends beyond the localized edematous area. This finding underscores the potential involvement of inflammatory path...

Humans Female Male Adult Angioedemas, Hereditary +14 autres

The association between systemic inflammation markers and paroxysmal atrial fibrillation.

04 Jul 2024
DOI: 10.1186/s12872-024-04004-9 PMID: 38961330

Systemic inflammation markers have recently been identified as being associated with cardiac disorders. However, limited research has been conducted to estimate the pre-diagnostic associations between... 91 participants in the PAF group and 97 participants in the non-PAF group were included in this study. We investigated the correlations between three systemic inflammation markers, namely the systemic... The proportion of patients with PAF gradually increased with increasing logSII, logSIRI, and logAISI tertiles. Compared to those in the lowest tertiles, the PAF risks in the highest logSII and logSIRI... In conclusion, our study reveals significant positive correlations between SII, SIRI, and AISI with the incidence of PAF....

Humans Atrial Fibrillation Male Female Middle Aged +10 autres