The role of the Oxytocin-Neurophysin I gene in contributing to human personality traits promoting sociality.
Journal
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
ISSN: 1872-7697
Titre abrégé: Int J Psychophysiol
Pays: Netherlands
ID NLM: 8406214
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
08
08
2017
revised:
23
02
2018
accepted:
25
02
2018
pubmed:
5
3
2018
medline:
29
1
2020
entrez:
5
3
2018
Statut:
ppublish
Résumé
Oxytocin (OT) plays a salient role in contributing to the high levels of human sociality that characterize our species. Across the lifespan this nonapeptide promotes prosocial behaviors and modulates stress responses. Curiously, the OXT-Neurophysin I gene has been little studied despite the fact this is the structural gene for the OT nonapeptide. In a large group of Han Chinese undergraduate students (n = 1593) we examined associations of two single nucleotide polymorphisms of the OXT- Neurophysin I gene with personality traits. Results indicated that the OXT-Neurophysin I rs2770378 was related to extraversion, agreeableness, and neuroticism. AA homozygous individuals reported more prosocial personality traits, compared to participants carrying the G allele. These results indicate that variants of the OXT-Neurophysin-I gene resonate with phenotypes that foster positive social interactions, which may in turn facilitate the social regulation of stress responses.
Identifiants
pubmed: 29501452
pii: S0167-8760(17)30443-9
doi: 10.1016/j.ijpsycho.2018.02.015
pii:
doi:
Substances chimiques
Neurophysins
0
Oxytocin
50-56-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-86Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.