Janus kinase-1 and 3 in ankylosing spondylitis.

Adult Biomarkers C-Reactive Protein / analysis Case-Control Studies Female Humans Janus Kinase 1 / genetics Janus Kinase 3 / genetics Leukocytes, Mononuclear / metabolism Male Middle Aged ROC Curve Severity of Illness Index Spondylitis, Ankylosing / genetics Taiwan
Acute-phase reactant Ankylosing spondylitis Janus kinase (JAK)

Journal

Journal of the Formosan Medical Association = Taiwan yi zhi
ISSN: 0929-6646
Titre abrégé: J Formos Med Assoc
Pays: Singapore
ID NLM: 9214933

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 09 08 2017
revised: 03 01 2018
accepted: 02 02 2018
pubmed: 14 3 2018
medline: 8 3 2019
entrez: 14 3 2018
Statut: ppublish

Résumé

To investigate the Janus kinase-1 and 3 (JAK-1 and 3) expression in peripheral blood mononuclear cells (PBMCs) in ankylosing spondylitis (AS). The levels of JAK-1 and JAK-3 mRNA in PBMCs, CD3 JAK-1 and JAK-3 expression in PB CD3 In AS, JAK-1 expression in PB cells rather than ESR or CRP might be regarded as a bio-marker for monitoring disease activity and functional index in AS. These findings have also suggested that JAK-1 and JAK-3 expression may play a role in the inflammatory processes in patients with AS.

Sections du résumé

BACKGROUND/PURPOSE OBJECTIVE
To investigate the Janus kinase-1 and 3 (JAK-1 and 3) expression in peripheral blood mononuclear cells (PBMCs) in ankylosing spondylitis (AS).
METHODS METHODS
The levels of JAK-1 and JAK-3 mRNA in PBMCs, CD3
RESULTS RESULTS
JAK-1 and JAK-3 expression in PB CD3
CONCLUSION CONCLUSIONS
In AS, JAK-1 expression in PB cells rather than ESR or CRP might be regarded as a bio-marker for monitoring disease activity and functional index in AS. These findings have also suggested that JAK-1 and JAK-3 expression may play a role in the inflammatory processes in patients with AS.

Identifiants

DOI: 10.1016/j.jfma.2018.02.001 PMID: 29530480
pubmed: 29530480
pii: S0929-6646(17)30584-3
doi: 10.1016/j.jfma.2018.02.001
pii:
doi:

Substances chimiques

Biomarkers 0
C-Reactive Protein 9007-41-4
JAK1 protein, human EC 2.7.10.2
JAK3 protein, human EC 2.7.10.2
Janus Kinase 1 EC 2.7.10.2
Janus Kinase 3 EC 2.7.10.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

134-141

Informations de copyright

Copyright © 2018. Published by Elsevier B.V.

Auteurs

Hsien-Tzung Liao (HT)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Tzu-Hao Li (TH)

Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Chiayi Branch, Taichung Veterans General Hospital, Taiwan.

Chun-Hsiung Chen (CH)

Division of Allergy, Immunology, and Rheumatology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan.

Hung-An Chen (HA)

Chi Mei Medical Center, Tainan, Taiwan.

Wei-Sheng Chen (WS)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Chien-Chih Lai (CC)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Chung-Tei Chou (CT)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Chang-Youh Tsai (CY)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan. Electronic address: cytsai@vghtpe.gov.tw.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéine C-réactive › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Janus kinases › Janus kinase 1 › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Janus kinases › Janus kinase 3 › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Courbe ROC › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Arthrite › Spondylarthrite › Spondylarthropathies › Spondyloarthrite axiale › Pelvispondylite rhumatismale › Janus kinase-1 and 3 in ankylosing spondylitis.
questionsmedicales.fr › Régions géographiques › Iles › Taïwan › Janus kinase-1 and 3 in ankylosing spondylitis.