Childhood and Parental Asthma, Future Risk of Bipolar Disorder and Schizophrenia Spectrum Disorders: A Population-Based Cohort Study.
Adolescent
Age Factors
Asthma
/ epidemiology
Bipolar Disorder
/ epidemiology
Child
Child of Impaired Parents
/ statistics & numerical data
Cohort Studies
Disease Susceptibility
/ epidemiology
Female
Hospitalization
/ statistics & numerical data
Humans
Male
Registries
/ statistics & numerical data
Risk
Schizophrenia
/ epidemiology
Sweden
/ epidemiology
asthma
epidemiology
etiology
inflammation
risk factor
schizophrenia
Journal
Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760
Informations de publication
Date de publication:
07 03 2019
07 03 2019
Historique:
pubmed:
14
3
2018
medline:
9
4
2020
entrez:
14
3
2018
Statut:
ppublish
Résumé
Mounting evidence implicates early life and prenatal immune disturbances in the etiology of severe mental illnesses. Asthma is a common illness associated with chronic aberrant immune responses. We aimed to determine if asthma in childhood and parents is associated with bipolar and schizophrenia spectrum disorders. A cohort study including all children born in Sweden 1973-1995 (N > 2 million) assessing associations between childhood hospitalization for asthma, parental asthma during and pre-pregnancy, and subsequent bipolar and schizophrenia spectrum disorders. Children with hospitalizations for asthma between 11 and 15 years had increased rates of bipolar (adjusted hazard ratio [aHR] = 1.73, 95% confidence interval [CI] = 1.21-2.47) and schizophrenia spectrum disorders (aHR = 1.62, 95% CI = 1.08-2.42). However, there was no association with asthma before aged 11. These results were supported by an analysis of siblings discordant for asthma. We found an association between both maternal and paternal asthma and bipolar disorder (aHR = 1.60, 95% CI = 1.27-2.02, and aHR = 1.44, 95% CI = 1.08-1.93, respectively), but not between parental asthma and schizophrenia spectrum disorders. As far as we are aware, this is the first study to find increased risk of bipolar disorder in children of individuals with asthma. Asthma admissions before aged 11 do not appear to be linked to bipolar or schizophrenia spectrum disorders. Taken together, our results do not suggest a straightforward link between asthma and severe mental illness via neurodevelopmental effects of inflammation, but potentially there is shared genetic vulnerability. This finding has implications for understanding the differential pathogenic mechanisms of bipolar and schizophrenia spectrum disorders.
Sections du résumé
BACKGROUND
Mounting evidence implicates early life and prenatal immune disturbances in the etiology of severe mental illnesses. Asthma is a common illness associated with chronic aberrant immune responses. We aimed to determine if asthma in childhood and parents is associated with bipolar and schizophrenia spectrum disorders.
METHODS
A cohort study including all children born in Sweden 1973-1995 (N > 2 million) assessing associations between childhood hospitalization for asthma, parental asthma during and pre-pregnancy, and subsequent bipolar and schizophrenia spectrum disorders.
RESULTS
Children with hospitalizations for asthma between 11 and 15 years had increased rates of bipolar (adjusted hazard ratio [aHR] = 1.73, 95% confidence interval [CI] = 1.21-2.47) and schizophrenia spectrum disorders (aHR = 1.62, 95% CI = 1.08-2.42). However, there was no association with asthma before aged 11. These results were supported by an analysis of siblings discordant for asthma. We found an association between both maternal and paternal asthma and bipolar disorder (aHR = 1.60, 95% CI = 1.27-2.02, and aHR = 1.44, 95% CI = 1.08-1.93, respectively), but not between parental asthma and schizophrenia spectrum disorders.
CONCLUSIONS
As far as we are aware, this is the first study to find increased risk of bipolar disorder in children of individuals with asthma. Asthma admissions before aged 11 do not appear to be linked to bipolar or schizophrenia spectrum disorders. Taken together, our results do not suggest a straightforward link between asthma and severe mental illness via neurodevelopmental effects of inflammation, but potentially there is shared genetic vulnerability. This finding has implications for understanding the differential pathogenic mechanisms of bipolar and schizophrenia spectrum disorders.
Identifiants
pubmed: 29534225
pii: 4925508
doi: 10.1093/schbul/sby023
pmc: PMC6403048
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
360-368Subventions
Organisme : Medical Research Council
ID : MR/K021362/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
Références
Mutat Res. 2010 Aug 7;690(1-2):24-39
pubmed: 19769993
Schizophr Bull. 2014 Jan;40(1):28-38
pubmed: 23960245
Bipolar Disord. 2010 Sep;12(6):638-46
pubmed: 20868462
Arch Gen Psychiatry. 2003 Nov;60(11):1125-30
pubmed: 14609888
Biometrics. 2000 Jun;56(2):645-6
pubmed: 10877330
PLoS One. 2010 Apr 12;5(4):e10134
pubmed: 20405032
Behav Brain Res. 2009 Dec 7;204(2):313-21
pubmed: 19136031
Springerplus. 2013 May 14;2(1):222
pubmed: 23853744
Schizophr Res. 2015 Mar;162(1-3):74-8
pubmed: 25620118
J Allergy Clin Immunol. 2014 May;133(5):1317-29
pubmed: 24529685
Schizophr Res. 2012 Jun;138(1):58-62
pubmed: 22391212
Lancet Respir Med. 2015 Oct;3(10):769-81
pubmed: 26423011
Bipolar Disord. 2014 Sep;16(6):624-32
pubmed: 24499422
Twin Res Hum Genet. 2017 Feb;20(1):60-65
pubmed: 28105965
Mol Psychiatry. 2016 Nov;21(11):1624-1632
pubmed: 26809841
J Affect Disord. 2014 Oct;168:30-6
pubmed: 25033475
Schizophr Bull. 2016 Jan;42(1):125-33
pubmed: 26303935
Transl Psychiatry. 2013 Feb 19;3:e228
pubmed: 23423137
Am J Respir Crit Care Med. 2000 May;161(5):1720-45
pubmed: 10806180
Int J Biol Sci. 2012;8(9):1281-90
pubmed: 23136556
J Clin Psychopharmacol. 2009 Jun;29(3):288-90
pubmed: 19440085
Scand J Public Health. 2017 Jul;45(17_suppl):36-40
pubmed: 28683663
Respirology. 2016 Jan;21(1):95-101
pubmed: 26390812
Science. 2013 Jan 18;339(6117):335-9
pubmed: 23329051
N Engl J Med. 1999 Feb 25;340(8):603-8
pubmed: 10029644
Epidemiology. 2010 May;21(3):383-8
pubmed: 20335814
Am J Psychiatry. 2006 Mar;163(3):521-8
pubmed: 16513876
Ann Allergy Asthma Immunol. 2015 Oct;115(4):282-7
pubmed: 26272280
Respir Med. 2007 Jul;101(7):1431-8
pubmed: 17350816
Placenta. 2017 Jun;54:17-23
pubmed: 28131319
J Affect Disord. 2017 Jan 15;208:41-46
pubmed: 27744125
Psychol Med. 2010 Mar;40(3):477-85
pubmed: 19627644
Allergy Asthma Proc. 2015 Mar-Apr;36(2):e23-8
pubmed: 25715235
Psychol Med. 2004 Jul;34(5):787-93
pubmed: 15500299
Epidemiology. 2012 Sep;23(5):713-20
pubmed: 22781362
Arch Gen Psychiatry. 2012 Jun;69(6):E1-8
pubmed: 22660967
Int J Epidemiol. 2011 Apr;40(2):345-9
pubmed: 21450688
J Psychiatr Res. 2014 Feb;49:25-30
pubmed: 24275549
Nat Rev Neurol. 2014 Nov;10(11):643-60
pubmed: 25311587
Br J Psychiatry. 2016 Jun;208(6):539-47
pubmed: 26989096
Ann Allergy Asthma Immunol. 2004 May;92(5):500-5
pubmed: 15191017
Psychol Med. 1995 Jul;25(4):859-68
pubmed: 7480464
Gen Hosp Psychiatry. 2003 Jan-Feb;25(1):27-33
pubmed: 12583925
Dev Psychopathol. 2000 Summer;12(3):501-27
pubmed: 11014750
Int J Environ Res Public Health. 2015 Dec 30;13(1):
pubmed: 26729146
Expert Rev Respir Med. 2012 Aug;6(4):397-406
pubmed: 22971065
J Allergy Clin Immunol. 1996 Mar;97(3):742-8
pubmed: 8613629
Psychol Med. 2013 Feb;43(2):239-57
pubmed: 22717193
BMC Public Health. 2011 Jun 09;11:450
pubmed: 21658213
JAMA Psychiatry. 2015 Jul;72(7):635-41
pubmed: 25830477