Liver induced transgene tolerance with AAV vectors.
AAV
Gene therapy
Immune tolerance
Immunology
Journal
Cellular immunology
ISSN: 1090-2163
Titre abrégé: Cell Immunol
Pays: Netherlands
ID NLM: 1246405
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
05
09
2017
revised:
01
12
2017
accepted:
03
12
2017
pubmed:
27
3
2018
medline:
7
5
2020
entrez:
27
3
2018
Statut:
ppublish
Résumé
Immune tolerance is a vital component of immunity, as persistent activation of immune cells causes significant tissue damage and loss of tolerance leads to autoimmunity. Likewise, unwanted immune responses can occur in inherited disorders, such as hemophilia and Pompe disease, in which patients lack any expression of protein, during treatment with enzyme replacement therapy, or gene therapy. While the liver has long been known as being tolerogenic, it was only recently appreciated in the last decade that liver directed adeno-associated virus (AAV) gene therapy can induce systemic tolerance to a transgene. In this review, we look at the mechanisms behind liver induced tolerance, discuss different factors influencing successful tolerance induction with AAV, and applications where AAV mediated tolerance may be helpful.
Identifiants
pubmed: 29576315
pii: S0008-8749(17)30221-6
doi: 10.1016/j.cellimm.2017.12.002
pmc: PMC5988960
mid: NIHMS954064
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103728Subventions
Organisme : NHLBI NIH HHS
ID : L40 HL115805
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128074
Pays : United States
Informations de copyright
Copyright © 2017 Elsevier Inc. All rights reserved.
Références
Clin Exp Immunol. 2015 Jun;180(3):484-98
pubmed: 25605587
Hepatology. 2003 Aug;38(2):403-12
pubmed: 12883484
Mol Ther. 2018 Jan 3;26(1):173-183
pubmed: 28943274
Nature. 1969 Aug 2;223(5205):472-6
pubmed: 4894426
J Virol. 2001 Aug;75(15):6969-76
pubmed: 11435577
J Exp Med. 2012 Sep 24;209(10):1713-22, S1-19
pubmed: 22966003
Gastroenterology. 1996 Apr;110(4):1175-81
pubmed: 8613007
J Virol. 2008 Jun;82(12):5887-911
pubmed: 18400866
Mol Ther. 2008 Feb;16(2):280-9
pubmed: 18059373
Gastroenterology. 1999 Jun;116(6):1428-40
pubmed: 10348827
Hum Gene Ther. 2016 Jul;27(7):478-96
pubmed: 27267688
Front Immunol. 2016 Jul 08;7:276
pubmed: 27456241
Blood. 2002 Apr 15;99(8):2670-6
pubmed: 11929752
Mol Ther. 2008 Oct;16(10):1703-9
pubmed: 18728640
Hepatology. 2009 Aug;50(2):612-21
pubmed: 19575456
Cancer Immunol Res. 2014 Nov;2(11):1080-9
pubmed: 25080445
Mol Ther. 2014 Feb;22(2):329-337
pubmed: 24419081
N Engl J Med. 2015 May 14;372(20):1887-97
pubmed: 25938638
Mol Ther. 2009 Jul;17(7):1187-96
pubmed: 19367261
Clin Exp Immunol. 1998 Dec;114(3):427-33
pubmed: 9844054
Mol Ther. 2011 Feb;19(2):326-34
pubmed: 21119620
J Hepatol. 2011 Feb;54(2):357-65
pubmed: 21084131
J Virol. 2002 May;76(9):4580-90
pubmed: 11932423
Nat Rev Immunol. 2009 Nov;9(11):811-6
pubmed: 19809471
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3865-70
pubmed: 19237554
Eur J Immunol. 2010 Oct;40(10):2667-76
pubmed: 20821731
Eur J Immunol. 1998 Jan;28(1):221-36
pubmed: 9485202
J Clin Invest. 2008 Oct;118(10):3403-10
pubmed: 18802476
Gene Ther. 2003 Dec;10(26):2112-8
pubmed: 14625565
Blood. 2012 Jan 26;119(4):957-66
pubmed: 22134170
Hepatology. 2015 Jul;62(1):279-91
pubmed: 25810240
Virology. 2008 Nov 25;381(2):194-202
pubmed: 18834608
Annu Rev Immunol. 2008;26:677-704
pubmed: 18173375
Hum Gene Ther. 2016 Jan;27(1):43-59
pubmed: 26603344
J Hepatol. 1995 Feb;22(2):226-9
pubmed: 7790711
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7827-32
pubmed: 18511559
Front Immunol. 2013 Nov 18;4:378
pubmed: 24302924
Hepatology. 1988 May-Jun;8(3):449-54
pubmed: 2453428
Mol Ther. 2014 Nov;22(11):1900-9
pubmed: 25048217
J Clin Invest. 2013 Dec;123(12):5310-8
pubmed: 24231351
PLoS One. 2009 Aug 04;4(8):e6376
pubmed: 19652717
J Virol. 2008 Aug;82(16):7875-85
pubmed: 18524821
Adv Immunol. 2010;108:111-65
pubmed: 21056730
Nat Immunol. 2013 Oct;14(10):996-1006
pubmed: 24048121
Mol Ther. 2017 Aug 2;25(8):1831-1842
pubmed: 28596114
Hum Gene Ther. 2002 Jul 20;13(11):1281-91
pubmed: 12162811
Mol Ther. 2009 Oct;17(10):1733-42
pubmed: 19603001
Cancer Res. 2009 Oct 15;69(20):8067-75
pubmed: 19826049
J Thromb Haemost. 2009 Jul;7 Suppl 1:88-91
pubmed: 19630776
Hum Gene Ther. 2014 Mar;25(3):180-8
pubmed: 24299335
Int Immunol. 2009 Oct;21(10):1105-11
pubmed: 19737784
Mol Ther. 2006 Jun;13(6):1085-92
pubmed: 16581301
N Engl J Med. 2010 Oct 7;363(15):1429-37
pubmed: 20925545
J Leukoc Biol. 2014 Oct;96(4):571-7
pubmed: 24970859
J Immunol. 1998 Jun 15;160(12):5729-34
pubmed: 9637481
Mol Ther Methods Clin Dev. 2016 Dec 07;3:16083
pubmed: 27933310
J Hepatol. 2008 Dec;49(6):1008-18
pubmed: 18926588
Liver Int. 2006 Dec;26(10):1175-86
pubmed: 17105582
Nat Rev Immunol. 2010 Jul;10(7):490-500
pubmed: 20559327
J Virol. 1996 May;70(5):3227-34
pubmed: 8627803
Am J Hum Genet. 2007 Nov;81(5):1042-9
pubmed: 17924344
Transplantation. 1994 Aug 27;58(4):484-91
pubmed: 8073517
Expert Opin Biol Ther. 2018 Jan;18(1):37-49
pubmed: 29057663
Mol Ther. 2011 May;19(5):876-85
pubmed: 21245849
Nature. 2014 Feb 20;506(7488):382-6
pubmed: 24390344
Hum Gene Ther. 2009 Jul;20(7):767-76
pubmed: 19309290
Gene Ther. 2001 Aug;8(16):1248-54
pubmed: 11509958
Trends Immunol. 2016 Oct;37(10):668-679
pubmed: 27616557
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4592-7
pubmed: 16537361
Mol Ther. 2005 Nov;12(5):876-84
pubmed: 16005263
Mol Ther. 2013 Dec;21(12):2227-35
pubmed: 24126962
World J Gastroenterol. 2010 Feb 7;16(5):636-40
pubmed: 20128035
Science. 2002 Apr 12;296(5566):301-5
pubmed: 11951032
Nat Rev Immunol. 2010 Nov;10(11):753-66
pubmed: 20972472
Comp Hepatol. 2004 Jan 14;3 Suppl 1:S24
pubmed: 14960176
Nat Rev Neurol. 2013 Oct;9(10):583-98
pubmed: 23938739
Hepatology. 2006 Nov;44(5):1182-90
pubmed: 17058232
Mol Ther. 2007 Sep;15(9):1677-85
pubmed: 17565352
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
N Engl J Med. 2011 May 26;364(21):1995-2005
pubmed: 21612468
Gut. 2007 Feb;56(2):243-52
pubmed: 16840505
Hepatology. 2009 Dec;50(6):1904-13
pubmed: 19787806
Blood. 2010 Dec 23;116(26):5842-8
pubmed: 20876851
Hepatology. 2008 Sep;48(3):978-90
pubmed: 18712788
Mol Ther. 2010 Apr;18(4):766-74
pubmed: 20068550
Blood. 2002 Sep 1;100(5):1662-9
pubmed: 12176886
Blood. 2013 Apr 25;121(17):3335-44
pubmed: 23426947
Curr Opin Pharmacol. 2015 Oct;24:94-104
pubmed: 26302254
PLoS One. 2012;7(5):e37671
pubmed: 22655063
Chem Res Toxicol. 2003 Dec;16(12):1514-9
pubmed: 14680364
Blood. 2015 Mar 5;125(10):1553-61
pubmed: 25568350
Mol Ther. 2016 Feb;24(1):53-65
pubmed: 26220272
Annu Rev Virol. 2017 Sep 29;4(1):511-534
pubmed: 28961410
Mol Ther. 2011 Jul;19(7):1263-72
pubmed: 21386826
J Immunol. 2009 Feb 15;182(4):1901-11
pubmed: 19201843
Mol Ther. 2015 Aug;23(8):1298-1307
pubmed: 26022732
J Clin Invest. 1995 Jul;96(1):447-55
pubmed: 7615817
J Immunol. 2004 Jan 15;172(2):1009-17
pubmed: 14707074
Hum Gene Ther Methods. 2016 Dec;27(6):228-237
pubmed: 27903094
Biochim Biophys Acta. 2016 Mar;1862(3):461-71
pubmed: 26527183
Int Immunol. 2006 Aug;18(8):1197-209
pubmed: 16772372
Curr Opin Crit Care. 2001 Apr;7(2):99-104
pubmed: 11373518
Methods Mol Biol. 2011;807:141-57
pubmed: 22034029
Nat Biotechnol. 2010 Jan;28(1):79-82
pubmed: 20037580
Cell Mol Immunol. 2015 Sep;12(5):566-71
pubmed: 26051475
Mol Ther. 2017 Aug 2;25(8):1815-1830
pubmed: 28552407
Nature. 1997 Oct 16;389(6652):737-42
pubmed: 9338786
Cell Immunol. 2019 Aug;342:103658
pubmed: 28645365
Transpl Immunol. 2000 Mar;8(1):49-56
pubmed: 10834610
J Clin Invest. 2013 Jul 1;123(8):3254-3271
pubmed: 23863627
Immunol Lett. 2014 Oct;161(2):216-21
pubmed: 24316407
Transplantation. 1991 May;51(5):1076-80
pubmed: 1827688
J Immunol. 1999 Feb 1;162(3):1401-7
pubmed: 9973395
EMBO Mol Med. 2013 Nov;5(11):1698-709
pubmed: 24106230
Nat Med. 2013 Jun;19(6):739-46
pubmed: 23624599
Blood. 2004 Aug 15;104(4):969-77
pubmed: 15105293
Hepatology. 2005 Jul;42(1):193-9
pubmed: 15962311
Blood. 2011 Jun 16;117(24):6459-68
pubmed: 21474674
Curr Opin Immunol. 2016 Jun;40:36-42
pubmed: 26974478
Mol Ther. 2016 Jun;24(6):1042-1049
pubmed: 27019999
Nat Biotechnol. 2006 Feb;24(2):198-204
pubmed: 16429148
Blood. 2006 Jul 1;108(1):107-15
pubmed: 16522813
Blood. 2013 Mar 21;121(12):2224-33
pubmed: 23325831
Fluids Barriers CNS. 2013 Jan 21;10(1):7
pubmed: 23336847
J Thromb Haemost. 2007 Jan;5(1):12-5
pubmed: 17239162
Exp Cell Res. 1988 May;176(1):38-48
pubmed: 3371424
Methods Mol Biol. 2011;707:3-17
pubmed: 21287325
Blood. 2009 Jan 22;113(4):797-806
pubmed: 18957684
Hepatology. 1998 Jan;27(1):93-9
pubmed: 9425923
Curr Gene Ther. 2005 Jun;5(3):323-31
pubmed: 15975009
Eur J Immunol. 2009 Nov;39(11):3147-59
pubmed: 19688742
Comp Hepatol. 2004 Jan 14;3 Suppl 1:S22
pubmed: 14960174
Mol Ther Methods Clin Dev. 2016 Jul 20;3:16049
pubmed: 27722180
Hepatology. 1986 Jul-Aug;6(4):718-22
pubmed: 3733004
Int J Clin Exp Pathol. 2013;6(2):116-23
pubmed: 23329997
Expert Rev Hematol. 2011 Oct;4(5):539-49
pubmed: 21939421
J Exp Med. 1996 Apr 1;183(4):1865-78
pubmed: 8666943
Gene Ther. 2012 Jun;19(6):694-700
pubmed: 22402323
Blood. 2007 Oct 1;110(7):2334-41
pubmed: 17609423
Mol Ther. 2012 Mar;20(3):572-9
pubmed: 22186792
J Transl Med. 2017 May 1;15(1):94
pubmed: 28460646
Mol Ther Methods Clin Dev. 2014 Apr 30;1:14013
pubmed: 25558460
Blood. 2007 Aug 15;110(4):1132-40
pubmed: 17438084
J Clin Invest. 2009 Aug;119(8):2388-98
pubmed: 19587448
Immunol Lett. 2003 Oct 31;89(2-3):225-8
pubmed: 14556982
Hepatology. 2003 May;37(5):1079-85
pubmed: 12717388
Clin Med Res. 2005 Nov;3(4):234-40
pubmed: 16303889
Sci Rep. 2016 Jan 22;6:19861
pubmed: 26794038
Am J Pathol. 2009 May;174(5):1575-87
pubmed: 19349365
J Clin Invest. 2003 May;111(9):1347-56
pubmed: 12727926
Hum Gene Ther. 2013 Sep;24(9):797-806
pubmed: 24010700
Hum Gene Ther. 2011 Apr;22(4):419-26
pubmed: 20919876
J Neuroimmune Pharmacol. 2012 Mar;7(1):74-94
pubmed: 21822588
Nat Med. 2006 Mar;12(3):342-7
pubmed: 16474400
Transplantation. 1994 Oct 15;58(7):816-20
pubmed: 7940717
Mol Ther. 2010 Jan;18(1):151-60
pubmed: 19888197
Cell Mol Immunol. 2016 May;13(3):277-92
pubmed: 27041638
Immunology. 2001 Jun;103(2):131-6
pubmed: 11412299
Eye (Lond). 2009 Oct;23(10):1885-9
pubmed: 19136922
J Hepatol. 2014 Sep;61(3):594-9
pubmed: 24798620
Blood. 2007 Feb 15;109(4):1414-21
pubmed: 17090654
Mol Ther Methods Clin Dev. 2016 Sep 28;3:16063
pubmed: 27738644
Hum Gene Ther. 2014 Sep;25(9):844-55
pubmed: 25072305
PLoS One. 2015 Oct 23;10(10):e0141161
pubmed: 26495986
Am J Pathol. 2004 Feb;164(2):511-9
pubmed: 14742257
Mol Ther. 2017 Apr 5;25(4):880-891
pubmed: 28284982