Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly.
Assembly
Gag
RNA
Retroviruses
gRNA packaging
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
22
02
2018
revised:
09
03
2018
accepted:
22
03
2018
pubmed:
28
3
2018
medline:
31
5
2019
entrez:
28
3
2018
Statut:
ppublish
Résumé
Retroviral Gag proteins are responsible for coordinating many aspects of virion assembly. Gag possesses two distinct nucleic acid binding domains, matrix (MA) and nucleocapsid (NC). One of the critical functions of Gag is to specifically recognize, bind, and package the retroviral genomic RNA (gRNA) into assembling virions. Gag interactions with cellular RNAs have also been shown to regulate aspects of assembly. Recent results have shed light on the role of MA and NC domain interactions with nucleic acids, and how they jointly function to ensure packaging of the retroviral gRNA. Here, we will review the literature regarding RNA interactions with NC, MA, as well as overall mechanisms employed by Gag to interact with RNA. The discussion focuses on human immunodeficiency virus type-1, but other retroviruses will also be discussed. A model is presented combining all of the available data summarizing the various factors and layers of selection Gag employs to ensure specific gRNA packaging and correct virion assembly.
Identifiants
pubmed: 29580971
pii: S1084-9521(17)30452-4
doi: 10.1016/j.semcdb.2018.03.015
pmc: PMC6167211
mid: NIHMS957328
pii:
doi:
Substances chimiques
Gene Products, gag
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
129-139Subventions
Organisme : NIAID NIH HHS
ID : F31 AI120868
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM065056
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008512
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008700
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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