Antigen processing and presentation in HIV infection.
HIV
Immune escape
Immunopeptidome
Protein degradation
T cells
Vaccine immunogen design
Journal
Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
11
09
2017
revised:
09
01
2018
accepted:
29
03
2018
pubmed:
11
4
2018
medline:
23
1
2020
entrez:
12
4
2018
Statut:
ppublish
Résumé
The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.
Identifiants
pubmed: 29636181
pii: S0161-5890(18)30106-8
doi: 10.1016/j.molimm.2018.03.027
pmc: PMC6174111
mid: NIHMS958145
pii:
doi:
Substances chimiques
AIDS Vaccines
0
Histocompatibility Antigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-74Subventions
Organisme : NIAID NIH HHS
ID : R56 AI122947
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129717
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI131912
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI084753
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI084106
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106725
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112493
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123286
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Nat Med. 1996 Mar;2(3):338-42
pubmed: 8612235
Nat Med. 2016 Jun;22(6):606-13
pubmed: 27183217
J Immunol. 2008 Jan 1;180(1):372-82
pubmed: 18097038
Science. 2016 Jul 22;353(6297):aaf6517
pubmed: 27463679
J Virol. 2008 Jun;82(11):5594-605
pubmed: 18385228
Nature. 2009 Apr 2;458(7238):641-5
pubmed: 19242411
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11530-5
pubmed: 21690407
PLoS Pathog. 2011 May;7(5):e1001341
pubmed: 21589893
Nat Immunol. 2002 Dec;3(12):1169-76
pubmed: 12436109
Cell Host Microbe. 2017 Apr 12;21(4):494-506.e4
pubmed: 28407485
Immunity. 2008 Dec 19;29(6):1009-21
pubmed: 19062316
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28348034
J Clin Invest. 2007 Nov;117(11):3563-75
pubmed: 17975674
Nat Rev Immunol. 2013 Jul;13(7):487-98
pubmed: 23797064
J Immunol. 2016 May 1;196(9):3595-607
pubmed: 27009491
Science. 2005 Mar 11;307(5715):1630-4
pubmed: 15761154
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):E323-31
pubmed: 21670269
Arthritis Rheum. 2010 Feb;62(2):420-9
pubmed: 20112406
J Immunol. 2001 May 15;166(10):6164-9
pubmed: 11342637
Science. 2016 Oct 21;354(6310):354-358
pubmed: 27846572
PLoS Pathog. 2015 Feb 27;11(2):e1004658
pubmed: 25723536
Immunity. 2012 Mar 23;36(3):491-501
pubmed: 22406268
Science. 2013 May 24;340(6135):1237874
pubmed: 23704576
J Virol. 1994 Sep;68(9):6103-10
pubmed: 8057491
PLoS Pathog. 2017 Jul 21;13(7):e1006529
pubmed: 28732035
PLoS One. 2012;7(8):e42579
pubmed: 22880042
Nature. 2011 May 26;473(7348):523-7
pubmed: 21562493
Curr Clin Microbiol Rep. 2015 Sep 1;2(3):125-136
pubmed: 27114893
J Transl Med. 2015 Feb 15;13:60
pubmed: 25879820
J Virol. 2012 Jan;86(1):277-83
pubmed: 22031937
J Virol. 2001 Dec;75(24):11983-91
pubmed: 11711588
J Biol Chem. 2006 Jul 21;281(29):20205-12
pubmed: 16702212
J Virol. 2005 Nov;79(21):13239-49
pubmed: 16227247
Eur J Immunol. 2010 Jul;40(7):1973-84
pubmed: 20468055
PLoS One. 2010 Aug 02;5(8):e11949
pubmed: 20689855
Immunity. 2006 Oct;25(4):533-43
pubmed: 17046682
Curr Pharm Des. 2009;15(28):3336-44
pubmed: 19860683
Nature. 2013 Oct 3;502(7469):100-4
pubmed: 24025770
J Infect Dis. 2010 Oct 15;202 Suppl 2:S309-14
pubmed: 20846038
J Immunol. 2006 Apr 1;176(7):4094-101
pubmed: 16547245
J Virol. 2015 Aug;89(15):7494-505
pubmed: 25972560
J Virol. 2015 Apr;89(7):4015-9
pubmed: 25589651
J Leukoc Biol. 2014 Apr;95(4):551-62
pubmed: 24532645
Curr Opin HIV AIDS. 2016 Jul;11(4):417-23
pubmed: 27078619
J Immunol. 2016 Jul 15;197(2):517-32
pubmed: 27288536
Nat Rev Microbiol. 2017 Oct 12;15(11):696
pubmed: 29021601
Cell Host Microbe. 2014 Dec 10;16(6):736-47
pubmed: 25464829
Curr Opin HIV AIDS. 2011 May;6(3):174-80
pubmed: 21502921
J Immunol. 2015 Nov 1;195(9):4075-84
pubmed: 26401000
J Virol. 2007 Nov;81(22):12608-18
pubmed: 17728232
PLoS One. 2007 Feb 21;2(2):e225
pubmed: 17311088
Nat Med. 2016 Aug;22(8):839-50
pubmed: 27400264
Science. 2004 Apr 23;304(5670):587-90
pubmed: 15001714
Immunol Rev. 2017 Jan;275(1):230-244
pubmed: 28133800
Nature. 2015 Jan 15;517(7534):281-2
pubmed: 25561174
J Exp Med. 2004 Apr 19;199(8):1053-63
pubmed: 15078897
J Biol Chem. 1998 Jul 24;273(30):18734-42
pubmed: 9668046
AIDS. 2013 Mar 27;27(6):899-905
pubmed: 23276808
Nat Rev Microbiol. 2016 Jan;14(1):55-60
pubmed: 26616417
Sci Rep. 2017 Jul 11;7(1):5072
pubmed: 28698575
Cell Mol Life Sci. 2005 May;62(9):1025-37
pubmed: 15868101
Nature. 1998 Jan 22;391(6665):397-401
pubmed: 9450757
J Exp Med. 2008 Oct 27;205(11):2537-50
pubmed: 18838548
J Virol. 2015 Jun;89(11):5760-71
pubmed: 25810538
J Virol. 2007 Nov;81(22):12382-93
pubmed: 17804494
Microbes Infect. 2008 Apr;10(5):455-61
pubmed: 18407775
J Clin Invest. 2013 Jan;123(1):380-93
pubmed: 23221345
J Immunol. 2016 Feb 15;196(4):1480-7
pubmed: 26783342
Nature. 2014 Aug 7;512(7512):74-7
pubmed: 25042999
Eur J Immunol. 2016 Jan;46(1):60-9
pubmed: 26467324
Nat Med. 2001 Mar;7(3):344-9
pubmed: 11231634
Cell. 2010 Nov 24;143(5):789-801
pubmed: 21111238
PLoS Pathog. 2016 Feb 01;12(2):e1005421
pubmed: 26828202
Science. 2010 Dec 10;330(6010):1551-7
pubmed: 21051598
PLoS Comput Biol. 2007 Apr 27;3(4):e75
pubmed: 17465674
Mol Ther. 2014 Feb;22(2):464-475
pubmed: 24166483
Eur J Immunol. 1997 May;27(5):1164-9
pubmed: 9174606
Cell. 1991 Sep 20;66(6):1145-53
pubmed: 1913805
Hum Vaccin Immunother. 2017 Dec 2;13(12):2859-2871
pubmed: 28678607
Science. 2006 Sep 8;313(5792):1444-7
pubmed: 16960008
Curr Top Microbiol Immunol. 2017;407:31-63
pubmed: 28653187
PLoS One. 2017 Apr 27;12(4):e0176418
pubmed: 28448594
J Immunol. 2012 Jun 15;188(12):5924-34
pubmed: 22586036
J Virol. 2014 Nov;88(22):12992-3004
pubmed: 25165114
Annu Rev Med. 2012;63:95-111
pubmed: 21942424
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13057-62
pubmed: 11087859
J Virol. 2014 Nov;88(22):12937-48
pubmed: 25165115
Science. 2014 Jul 11;345(6193):1254031
pubmed: 25013080
J Immunol. 2014 Nov 1;193(9):4322-4334
pubmed: 25230751
J Virol. 2013 May;87(10):5461-7
pubmed: 23468488
J Exp Med. 2009 Jun 8;206(6):1253-72
pubmed: 19487423
J Virol. 1998 May;72(5):3845-50
pubmed: 9557668
Science. 2016 Feb 12;351(6274):714-20
pubmed: 26797147
Adv Immunol. 2006;92:225-305
pubmed: 17145306
Sci Rep. 2016 Apr 06;6:24032
pubmed: 27049119
Expert Opin Biol Ther. 2017 Mar;17(3):295-303
pubmed: 28095712
Annu Rev Immunol. 2013;31:443-73
pubmed: 23298205
PLoS Comput Biol. 2010 Jun 24;6(6):e1000830
pubmed: 20613855
Curr Opin Immunol. 2007 Feb;19(1):79-86
pubmed: 17140786
J Immunol. 2016 Nov 15;197(10):3999-4013
pubmed: 27733554
Eur J Immunol. 1998 Sep;28(9):2854-63
pubmed: 9754572
Nat Immunol. 2002 Nov;3(11):1061-8
pubmed: 12368910
J Immunol. 2010 Mar 15;184(6):3016-24
pubmed: 20154207
J Virol. 2016 Sep 12;90(19):8605-20
pubmed: 27440904
Mol Cell Proteomics. 2015 Mar;14(3):658-73
pubmed: 25576301
Immunol Rev. 2017 Jan;275(1):245-261
pubmed: 28133811
Immunity. 1998 Apr;8(4):483-95
pubmed: 9586638
Immunogenetics. 2001 Mar;53(2):87-94
pubmed: 11345595
J Immunol. 2011 Feb 15;186(4):2065-72
pubmed: 21228349
PLoS Pathog. 2011 May;7(5):e1002049
pubmed: 21589903
Nature. 2015 Jan 15;517(7534):381-5
pubmed: 25561180
Nature. 2000 Apr 13;404(6779):770-4
pubmed: 10783891
J Virol. 2004 Dec;78(24):13901-10
pubmed: 15564498
Nat Med. 2007 Jan;13(1):100-6
pubmed: 17187074
J Virol. 2016 Aug 12;90(17):7596-606
pubmed: 27307568
J Exp Med. 2006 May 15;203(5):1249-58
pubmed: 16636134
Immunity. 2000 Jan;12(1):83-93
pubmed: 10661408
Methods Mol Biol. 2005;301:271-81
pubmed: 15917638
Curr Opin Immunol. 2016 Jun;40:70-7
pubmed: 27018930
Nat Immunol. 2011 Jan;12(1):45-53
pubmed: 21151101
J Immunol. 1996 Oct 15;157(8):3242-9
pubmed: 8871618
Nature. 2002 Oct 3;419(6906):480-3
pubmed: 12368856
Cancer Immunol Res. 2014 Apr;2(4):341-50
pubmed: 24764581
BMC Bioinformatics. 2007 Jul 04;8:238
pubmed: 17608956
Nat Med. 2002 May;8(5):493-9
pubmed: 11984594
Mol Ther. 2016 Apr;24(4):832-42
pubmed: 26743582
Biochem Biophys Res Commun. 2001 Jul 27;285(4):863-72
pubmed: 11467830
J Exp Med. 2010 Jan 18;207(1):61-75
pubmed: 20065065
J Virol. 2013 Apr;87(8):4751-5
pubmed: 23388715
J Immunol. 2007 Mar 1;178(5):2746-54
pubmed: 17312117
PLoS Pathog. 2016 Jan 07;12(1):e1005349
pubmed: 26741490
J Exp Med. 2007 Oct 1;204(10):2473-85
pubmed: 17893201
Blood. 2006 Jun 15;107(12):4781-9
pubmed: 16467198
Cell Rep. 2014 Apr 24;7(2):448-463
pubmed: 24726370
J Virol. 2011 Feb;85(4):1541-53
pubmed: 21106750
Retrovirology. 2015 Feb 10;12:15
pubmed: 25809376
J Infect Dis. 2009 Jul 15;200(2):236-43
pubmed: 19505257
Eur J Immunol. 2016 May;46(5):1109-18
pubmed: 26909514
J Biol Chem. 2017 Mar 31;292(13):5262-5270
pubmed: 28179428
Retrovirology. 2015 Feb 08;12:14
pubmed: 25756928
Mol Immunol. 2015 Dec;68(2 Pt A):72-6
pubmed: 26006050
Cell Host Microbe. 2012 Oct 18;12(4):396-407
pubmed: 23084910
Nat Immunol. 2009 Jun;10(6):636-46
pubmed: 19412183
J Immunol Res. 2016;2016:2695396
pubmed: 27699181
Adv Virus Res. 2016;95:43-85
pubmed: 27112280
J Clin Invest. 2011 Jun;121(6):2480-92
pubmed: 21555856
Immunogenetics. 2015 Feb;67(2):85-93
pubmed: 25475908
J Virol. 2002 Mar;76(5):2298-305
pubmed: 11836408
J Virol. 2004 Jul;78(13):7069-78
pubmed: 15194783
Nat Rev Immunol. 2008 Aug;8(8):607-18
pubmed: 18641646
J Virol. 1998 Mar;72(3):2208-12
pubmed: 9499078
Blood. 2009 Jun 18;113(25):6351-60
pubmed: 19389882
Eur J Immunol. 2017 May;47(5):818-829
pubmed: 28266028
Cell. 2013 Oct 24;155(3):531-9
pubmed: 24243013
PLoS Pathog. 2015 Mar 17;11(3):e1004725
pubmed: 25781895
J Virol. 1994 Jul;68(7):4650-5
pubmed: 8207839
J Virol. 2007 Aug;81(15):8346-51
pubmed: 17507468
J Virol. 2017 Oct 13;91(21):
pubmed: 28814521
J Virol. 2012 May;86(9):5230-43
pubmed: 22379086
Nat Immunol. 2006 Feb;7(2):179-89
pubmed: 16388312
Nat Immunol. 2006 Feb;7(2):173-8
pubmed: 16369537
J Cell Sci. 2001 Mar;114(Pt 5):845-51
pubmed: 11181168
J Immunol. 2014 Apr 15;192(8):3496-506
pubmed: 24616479
J Exp Med. 2010 Jan 18;207(1):51-9
pubmed: 20065064
J Exp Med. 1992 Feb 1;175(2):481-7
pubmed: 1732413