Titre : Antigènes d'histocompatibilité

Antigènes d'histocompatibilité : Questions médicales fréquentes

Nom anglais: Histocompatibility Antigens

Descriptor UI: D006649

Tree Number: D23.050.705.552

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une incompatibilité d'histocompatibilité ?

Des tests sanguins pour déterminer les types d'antigènes HLA sont effectués.
Antigènes d'histocompatibilité HLA
#2

Quels tests sont utilisés pour les antigènes HLA ?

Les tests de typage HLA, comme le typage par PCR, sont couramment utilisés.
Typage HLA Antigènes d'histocompatibilité
#3

Les tests d'histocompatibilité sont-ils obligatoires ?

Oui, ils sont essentiels avant une transplantation d'organe pour éviter le rejet.
Transplantation d'organe Antigènes d'histocompatibilité
#4

Peut-on détecter les antigènes d'histocompatibilité par biopsie ?

Oui, une biopsie peut aider à évaluer la compatibilité tissulaire.
Biopsie Antigènes d'histocompatibilité
#5

Quels sont les marqueurs d'une réaction immunitaire ?

La présence d'anticorps anti-HLA dans le sang indique une réaction immunitaire.
Anticorps Antigènes d'histocompatibilité

Symptômes 5

#1

Quels symptômes indiquent un rejet de greffe ?

Les symptômes incluent douleur, fièvre, et dysfonction de l'organe greffé.
Rejet de greffe Antigènes d'histocompatibilité
#2

Comment se manifeste une réaction allergique aux antigènes ?

Elle peut se manifester par des éruptions cutanées, démangeaisons et œdème.
Réaction allergique Antigènes d'histocompatibilité
#3

Les antigènes d'histocompatibilité causent-ils des symptômes ?

Ils ne causent pas de symptômes directs, mais influencent la réponse immunitaire.
Réponse immunitaire Antigènes d'histocompatibilité
#4

Quels signes indiquent une incompatibilité HLA ?

Des signes de rejet ou d'inflammation peuvent indiquer une incompatibilité HLA.
Incompatibilité HLA Antigènes d'histocompatibilité
#5

Les symptômes d'une greffe échouée sont-ils immédiats ?

Ils peuvent apparaître rapidement ou se développer sur plusieurs jours.
Échec de greffe Antigènes d'histocompatibilité

Prévention 5

#1

Comment prévenir le rejet d'une greffe ?

Un suivi régulier et une adhésion stricte au traitement immunosuppresseur sont essentiels.
Prévention du rejet Transplantation d'organe
#2

Les donneurs et receveurs doivent-ils être compatibles ?

Oui, la compatibilité HLA entre donneur et receveur est cruciale pour le succès de la greffe.
Compatibilité HLA Antigènes d'histocompatibilité
#3

Quelles mesures de précaution sont recommandées ?

Éviter les infections et suivre un régime alimentaire sain sont recommandés.
Prévention des infections Antigènes d'histocompatibilité
#4

Les vaccinations sont-elles importantes après une greffe ?

Oui, les vaccinations sont essentielles pour prévenir les infections post-greffe.
Vaccination Transplantation d'organe
#5

Comment le suivi médical aide-t-il à prévenir le rejet ?

Un suivi régulier permet d'ajuster les traitements et de détecter précocement les problèmes.
Suivi médical Rejet de greffe

Traitements 5

#1

Quels traitements sont utilisés pour prévenir le rejet ?

Les immunosuppresseurs comme la ciclosporine sont couramment prescrits.
Immunosuppresseurs Rejet de greffe
#2

Comment traiter une réaction au greffon ?

Des corticostéroïdes et des ajustements immunosuppresseurs sont souvent nécessaires.
Corticostéroïdes Rejet de greffe
#3

Les traitements sont-ils différents selon le type de greffe ?

Oui, les protocoles varient selon le type d'organe greffé et le risque de rejet.
Transplantation d'organe Antigènes d'histocompatibilité
#4

Peut-on utiliser des thérapies géniques pour les antigènes ?

Des recherches sont en cours sur l'utilisation de thérapies géniques pour moduler la réponse immunitaire.
Thérapie génique Antigènes d'histocompatibilité
#5

Les traitements préventifs sont-ils efficaces ?

Oui, ils réduisent significativement le risque de rejet et améliorent la survie des greffes.
Prévention du rejet Antigènes d'histocompatibilité

Complications 5

#1

Quelles sont les complications possibles après une greffe ?

Les complications incluent le rejet, les infections et les effets secondaires des médicaments.
Complications de la greffe Rejet de greffe
#2

Le rejet aigu est-il une complication fréquente ?

Oui, le rejet aigu est une complication courante dans les premières semaines après la greffe.
Rejet aigu Antigènes d'histocompatibilité
#3

Comment les infections sont-elles liées aux antigènes ?

Les immunosuppresseurs augmentent le risque d'infections en affaiblissant le système immunitaire.
Infections Immunosuppresseurs
#4

Les complications peuvent-elles être évitées ?

Certaines complications peuvent être évitées par un suivi rigoureux et un traitement approprié.
Prévention des complications Transplantation d'organe
#5

Quels sont les effets secondaires des immunosuppresseurs ?

Les effets secondaires incluent des infections, des troubles gastro-intestinaux et des problèmes rénaux.
Effets secondaires Immunosuppresseurs

Facteurs de risque 5

#1

Quels facteurs augmentent le risque de rejet ?

Les antécédents de rejet, la non-adhésion au traitement et la compatibilité HLA faible augmentent le risque.
Facteurs de risque Rejet de greffe
#2

L'âge influence-t-il le risque de complications ?

Oui, les patients plus âgés ont un risque accru de complications après une greffe.
Âge Complications de la greffe
#3

Les maladies auto-immunes sont-elles un facteur de risque ?

Oui, elles peuvent augmenter le risque de rejet et de complications post-greffe.
Maladies auto-immunes Rejet de greffe
#4

Le mode de vie affecte-t-il le risque de rejet ?

Oui, un mode de vie sain peut réduire le risque de complications et améliorer la récupération.
Mode de vie Rejet de greffe
#5

Les antécédents familiaux influencent-ils le risque ?

Oui, des antécédents familiaux de maladies immunitaires peuvent augmenter le risque de rejet.
Antécédents familiaux Rejet de greffe
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transport de folate réduit", "alternateName": "Reduced Folate Carrier Protein", "url": "https://questionsmedicales.fr/mesh/D058978", "about": { "@type": "MedicalCondition", "name": "Protéine de transport de folate réduit", "code": { "@type": "MedicalCode", "code": "D058978", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D23.050.705.552.600.663" } } }, { "@type": "MedicalWebPage", "name": "Inhibiteur bêta de la dissociation des nucléotides guanylés spécifique des protéines rho", "alternateName": "rho Guanine Nucleotide Dissociation Inhibitor beta", "url": "https://questionsmedicales.fr/mesh/D062949", "about": { "@type": "MedicalCondition", "name": "Inhibiteur bêta de la dissociation des nucléotides guanylés spécifique des protéines rho", "code": { "@type": "MedicalCode", "code": "D062949", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D23.050.705.552.600.700" } } }, { 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"https://questionsmedicales.fr/author/Kyra%20J%20Fuchs", "affiliation": { "@type": "Organization", "name": "Leiden University Medical Center, Leiden, Netherlands." } }, { "@type": "Person", "name": "Martin Plasil", "url": "https://questionsmedicales.fr/author/Martin%20Plasil", "affiliation": { "@type": "Organization", "name": "Research group Animal Immunogenomics, CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czechia." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Neutral Forces and Balancing Selection Interplay to Shape the Major Histocompatibility Complex Spatial Patterns in the Striped Hamster in Inner Mongolia: Suggestive of Broad-Scale Local Adaptation.", "datePublished": "2023-07-22", "url": "https://questionsmedicales.fr/article/37510404", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3390/genes14071500" } }, { "@type": "ScholarlyArticle", "name": "Allele-specific quantification of human leukocyte antigen transcript 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d'histocompatibilité - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Antigènes d'histocompatibilité", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2026-05-11", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Antigènes d'histocompatibilité", "description": "Comment diagnostiquer une incompatibilité d'histocompatibilité ?\nQuels tests sont utilisés pour les antigènes HLA ?\nLes tests d'histocompatibilité sont-ils obligatoires ?\nPeut-on détecter les antigènes d'histocompatibilité par biopsie ?\nQuels sont les marqueurs d'une réaction immunitaire ?", "url": "https://questionsmedicales.fr/mesh/D006649#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Antigènes d'histocompatibilité", "description": "Quels symptômes indiquent un rejet de greffe ?\nComment se manifeste une réaction allergique aux antigènes ?\nLes antigènes d'histocompatibilité causent-ils des symptômes ?\nQuels signes indiquent une incompatibilité HLA ?\nLes symptômes d'une greffe échouée sont-ils immédiats ?", "url": "https://questionsmedicales.fr/mesh/D006649#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Antigènes d'histocompatibilité", "description": "Comment prévenir le rejet d'une greffe ?\nLes donneurs et receveurs doivent-ils être compatibles ?\nQuelles mesures de précaution sont recommandées ?\nLes vaccinations sont-elles importantes après une greffe ?\nComment le suivi médical aide-t-il à prévenir le rejet ?", "url": "https://questionsmedicales.fr/mesh/D006649#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Antigènes d'histocompatibilité", "description": "Quels traitements sont utilisés pour prévenir le rejet ?\nComment traiter une réaction au greffon ?\nLes traitements sont-ils différents selon le type de greffe ?\nPeut-on utiliser des thérapies géniques pour les antigènes ?\nLes traitements préventifs sont-ils efficaces ?", "url": "https://questionsmedicales.fr/mesh/D006649#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Antigènes d'histocompatibilité", "description": "Quelles sont les complications possibles après une greffe ?\nLe rejet aigu est-il une complication fréquente ?\nComment les infections sont-elles liées aux antigènes ?\nLes complications peuvent-elles être évitées ?\nQuels sont les effets secondaires des immunosuppresseurs ?", "url": "https://questionsmedicales.fr/mesh/D006649#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Antigènes d'histocompatibilité", "description": "Quels facteurs augmentent le risque de rejet ?\nL'âge influence-t-il le risque de complications ?\nLes maladies auto-immunes sont-elles un facteur de risque ?\nLe mode de vie affecte-t-il le risque de rejet ?\nLes antécédents familiaux influencent-ils le risque ?", "url": "https://questionsmedicales.fr/mesh/D006649#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une incompatibilité d'histocompatibilité ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests sanguins pour déterminer les types d'antigènes HLA sont effectués." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour les antigènes HLA ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests de typage HLA, comme le typage par PCR, sont couramment utilisés." } }, { "@type": "Question", "name": "Les tests d'histocompatibilité sont-ils obligatoires ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils sont essentiels avant une transplantation d'organe pour éviter le rejet." } }, { "@type": "Question", "name": "Peut-on détecter les antigènes d'histocompatibilité par biopsie ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une biopsie peut aider à évaluer la compatibilité tissulaire." } }, { "@type": "Question", "name": "Quels sont les marqueurs d'une réaction immunitaire ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "La présence d'anticorps anti-HLA dans le sang indique une réaction immunitaire." } }, { "@type": "Question", "name": "Quels symptômes indiquent un rejet de greffe ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent douleur, fièvre, et dysfonction de l'organe greffé." } }, { "@type": "Question", "name": "Comment se manifeste une réaction allergique aux antigènes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut se manifester par des éruptions cutanées, démangeaisons et œdème." } }, { "@type": "Question", "name": "Les antigènes d'histocompatibilité causent-ils des symptômes ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Ils ne causent pas de symptômes directs, mais influencent la réponse immunitaire." } }, { "@type": "Question", "name": "Quels signes indiquent une incompatibilité HLA ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des signes de rejet ou d'inflammation peuvent indiquer une incompatibilité HLA." } }, { "@type": "Question", "name": "Les symptômes d'une greffe échouée sont-ils immédiats ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent apparaître rapidement ou se développer sur plusieurs jours." } }, { "@type": "Question", "name": "Comment prévenir le rejet d'une greffe ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier et une adhésion stricte au traitement immunosuppresseur sont essentiels." } }, { "@type": "Question", "name": "Les donneurs et receveurs doivent-ils être compatibles ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la compatibilité HLA entre donneur et receveur est cruciale pour le succès de la greffe." } }, { "@type": "Question", "name": "Quelles mesures de précaution sont recommandées ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Éviter les infections et suivre un régime alimentaire sain sont recommandés." } }, { "@type": "Question", "name": "Les vaccinations sont-elles importantes après une greffe ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les vaccinations sont essentielles pour prévenir les infections post-greffe." } }, { "@type": "Question", "name": "Comment le suivi médical aide-t-il à prévenir le rejet ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier permet d'ajuster les traitements et de détecter précocement les problèmes." } }, { "@type": "Question", "name": "Quels traitements sont utilisés pour prévenir le rejet ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les immunosuppresseurs comme la ciclosporine sont couramment prescrits." } }, { "@type": "Question", "name": "Comment traiter une réaction au greffon ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des corticostéroïdes et des ajustements immunosuppresseurs sont souvent nécessaires." } }, { "@type": "Question", "name": "Les traitements sont-ils différents selon le type de greffe ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les protocoles varient selon le type d'organe greffé et le risque de rejet." } }, { "@type": "Question", "name": "Peut-on utiliser des thérapies géniques pour les antigènes ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des recherches sont en cours sur l'utilisation de thérapies géniques pour moduler la réponse immunitaire." } }, { "@type": "Question", "name": "Les traitements préventifs sont-ils efficaces ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils réduisent significativement le risque de rejet et améliorent la survie des greffes." } }, { "@type": "Question", "name": "Quelles sont les complications possibles après une greffe ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent le rejet, les infections et les effets secondaires des médicaments." } }, { "@type": "Question", "name": "Le rejet aigu est-il une complication fréquente ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le rejet aigu est une complication courante dans les premières semaines après la greffe." } }, { "@type": "Question", "name": "Comment les infections sont-elles liées aux antigènes ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les immunosuppresseurs augmentent le risque d'infections en affaiblissant le système immunitaire." } }, { "@type": "Question", "name": "Les complications peuvent-elles être évitées ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être évitées par un suivi rigoureux et un traitement approprié." } }, { "@type": "Question", "name": "Quels sont les effets secondaires des immunosuppresseurs ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires incluent des infections, des troubles gastro-intestinaux et des problèmes rénaux." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque de rejet ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents de rejet, la non-adhésion au traitement et la compatibilité HLA faible augmentent le risque." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de complications ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les patients plus âgés ont un risque accru de complications après une greffe." } }, { "@type": "Question", "name": "Les maladies auto-immunes sont-elles un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent augmenter le risque de rejet et de complications post-greffe." } }, { "@type": "Question", "name": "Le mode de vie affecte-t-il le risque de rejet ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sain peut réduire le risque de complications et améliorer la récupération." } }, { "@type": "Question", "name": "Les antécédents familiaux influencent-ils le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de maladies immunitaires peuvent augmenter le risque de rejet." } } ] } ] }
Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

Validation scientifique effectuée le 07/05/2026

Contenu vérifié selon les dernières recommandations médicales

En savoir plus sur Dr Menir

Sous-catégories

61 au total
└─

Antigènes d'histocompatibilité de classe I

Histocompatibility Antigens Class I D015395 - D23.050.705.552.100
└─

Antigènes d'histocompatibilité de classe II

Histocompatibility Antigens Class II D000949 - D23.050.705.552.410
└─

Antigènes HLA

HLA Antigens D006680 - D23.050.705.552.450
└─

Antigènes mineurs d'histocompatibilité

Minor Histocompatibility Antigens D015778 - D23.050.705.552.600
└─└─

bêta-2-Microglobuline

beta 2-Microglobulin D001613 - D23.050.705.552.100.175
└─└─

Protéine de l'hémochromatose

Hemochromatosis Protein D000071020 - D23.050.705.552.100.375
└─└─

Antigènes H-2

H-2 Antigens D006183 - D23.050.705.552.410.199
└─└─

Antigènes HLA-A

HLA-A Antigens D015234 - D23.050.705.552.450.370
└─└─

Antigènes HLA-B

HLA-B Antigens D015235 - D23.050.705.552.450.380
└─└─

Antigènes HLA-C

HLA-C Antigens D015236 - D23.050.705.552.450.390
└─└─

Antigènes HLA-D

HLA-D Antigens D006681 - D23.050.705.552.450.400
└─└─

Antigènes HLA-G

HLA-G Antigens D059951 - D23.050.705.552.450.700
└─└─

Cathepsine H

Cathepsin H D056655 - D23.050.705.552.600.300
└─└─

Focal adhesion kinase 2

Focal Adhesion Kinase 2 D051418 - D23.050.705.552.600.350
└─└─

Antigène HY

H-Y Antigen D006182 - D23.050.705.552.600.400
└─└─

Récepteurs purinergiques P2X5

Receptors, Purinergic P2X5 D058485 - D23.050.705.552.600.625
└─└─

Protéine de transport de folate réduit

Reduced Folate Carrier Protein D058978 - D23.050.705.552.600.663
└─└─

Inhibiteur bêta de la dissociation des nucléotides guanylés spécifique des protéines rho

rho Guanine Nucleotide Dissociation Inhibitor beta D062949 - D23.050.705.552.600.700
└─└─

Thymidine phosphorylase

Thymidine Phosphorylase D013939 - D23.050.705.552.600.850
└─└─

Protéine kinase déficiente en lysine WNK-1

WNK Lysine-Deficient Protein Kinase 1 D000076204 - D23.050.705.552.600.925
└─└─└─

Antigène HLA-A1

HLA-A1 Antigen D015788 - D23.050.705.552.450.370.372
└─└─└─

Antigène HLA-A2

HLA-A2 Antigen D015789 - D23.050.705.552.450.370.374
└─└─└─

Antigène HLA-A3

HLA-A3 Antigen D015791 - D23.050.705.552.450.370.376
└─└─└─

Antigène HLA-A11

HLA-A11 Antigen D059870 - D23.050.705.552.450.370.500
└─└─└─

Antigène HLA-A24

HLA-A24 Antigen D059871 - D23.050.705.552.450.370.600
└─└─└─

Antigène HLA-B7

HLA-B7 Antigen D015793 - D23.050.705.552.450.380.070
└─└─└─

Antigène HLA-B8

HLA-B8 Antigen D015795 - D23.050.705.552.450.380.080
└─└─└─

Antigène HLA-B13

HLA-B13 Antigen D059908 - D23.050.705.552.450.380.130
└─└─└─

Antigène HLA-B14

HLA-B14 Antigen D059909 - D23.050.705.552.450.380.140
└─└─└─

Antigène HLA-B15

HLA-B15 Antigen D059910 - D23.050.705.552.450.380.150
└─└─└─

Antigène HLA-B18

HLA-B18 Antigen D059911 - D23.050.705.552.450.380.180
└─└─└─

Antigène HLA-B27

HLA-B27 Antigen D015796 - D23.050.705.552.450.380.270
└─└─└─

Antigène HLA-B35

HLA-B35 Antigen D015797 - D23.050.705.552.450.380.350
└─└─└─

Antigène HLA-B37

HLA-B37 Antigen D059912 - D23.050.705.552.450.380.370
└─└─└─

Antigène HLA-B38

HLA-B38 Antigen D059945 - D23.050.705.552.450.380.380
└─└─└─

Antigène HLA-B39

HLA-B39 Antigen D059946 - D23.050.705.552.450.380.390
└─└─└─

Antigène HLA-B40

HLA-B40 Antigen D059947 - D23.050.705.552.450.380.400
└─└─└─

Antigène HLA-B44

HLA-B44 Antigen D059948 - D23.050.705.552.450.380.440
└─└─└─

Antigène HLA-B51

HLA-B51 Antigen D059949 - D23.050.705.552.450.380.510
└─└─└─

Antigène HLA-B52

HLA-B52 Antigen D059950 - D23.050.705.552.450.380.520
└─└─└─

Antigènes HLA-DP

HLA-DP Antigens D006682 - D23.050.705.552.450.400.420
└─└─└─

Antigènes HLA-DQ

HLA-DQ Antigens D006683 - D23.050.705.552.450.400.430
└─└─└─

Antigènes HLA-DR

HLA-DR Antigens D006684 - D23.050.705.552.450.400.440
└─└─└─└─

Chaines alpha des antigènes HLA-DP

HLA-DP alpha-Chains D059867 - D23.050.705.552.450.400.420.500
└─└─└─└─

Chaines bêta des antigènes HLA-DP

HLA-DP beta-Chains D059868 - D23.050.705.552.450.400.420.750
└─└─└─└─

Chaines alpha des antigènes HLA-DQ

HLA-DQ alpha-Chains D059848 - D23.050.705.552.450.400.430.500
└─└─└─└─

Chaines bêta des antigènes HLA-DQ

HLA-DQ beta-Chains D059866 - D23.050.705.552.450.400.430.750
└─└─└─└─

Chaines alpha des antigènes HLA-DR

HLA-DR alpha-Chains D059805 - D23.050.705.552.450.400.440.222
└─└─└─└─

Chaines bêta des antigènes HLA-DR

HLA-DR beta-Chains D059806 - D23.050.705.552.450.400.440.333
└─└─└─└─

Sous-types sérologiques HLA-DR

HLA-DR Serological Subtypes D059810 - D23.050.705.552.450.400.440.389
└─└─└─└─└─

Chaines HLA-DRB1

HLA-DRB1 Chains D059811 - D23.050.705.552.450.400.440.333.500
└─└─└─└─└─

Chaines HLA-DRB3

HLA-DRB3 Chains D059826 - D23.050.705.552.450.400.440.333.750
└─└─└─└─└─

Chaines HLA-DRB4

HLA-DRB4 Chains D059845 - D23.050.705.552.450.400.440.333.875
└─└─└─└─└─

Chaines HLA-DRB5

HLA-DRB5 Chains D059847 - D23.050.705.552.450.400.440.333.937
└─└─└─└─└─

Antigène HLA-DR1

HLA-DR1 Antigen D015798 - D23.050.705.552.450.400.440.389.500
└─└─└─└─└─

Antigène HLA-DR2

HLA-DR2 Antigen D015802 - D23.050.705.552.450.400.440.389.750
└─└─└─└─└─

Antigène HLA-DR3

HLA-DR3 Antigen D015803 - D23.050.705.552.450.400.440.389.875
└─└─└─└─└─

Antigène HLA-DR4

HLA-DR4 Antigen D015804 - D23.050.705.552.450.400.440.389.937
└─└─└─└─└─

Antigène HLA-DR5

HLA-DR5 Antigen D015805 - D23.050.705.552.450.400.440.389.968
└─└─└─└─└─

Antigène HLA-DR6

HLA-DR6 Antigen D015808 - D23.050.705.552.450.400.440.389.984
└─└─└─└─└─

Antigène HLA-DR7

HLA-DR7 Antigen D015809 - D23.050.705.552.450.400.440.389.992

Auteurs principaux

J H Frederik Falkenburg

4 publications dans cette catégorie

Affiliations :
  • Leiden University of Medical Center, Leiden, Netherlands.
Publications dans "Antigènes d'histocompatibilité" :

Marieke Griffioen

4 publications dans cette catégorie

Affiliations :
  • Leiden University Medical Center, Leiden, Netherlands.
Publications dans "Antigènes d'histocompatibilité" :

Stephen R Spellman

3 publications dans cette catégorie

Affiliations :
  • Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, United States.
Publications dans "Antigènes d'histocompatibilité" :

Kyra J Fuchs

3 publications dans cette catégorie

Affiliations :
  • Leiden University Medical Center, Leiden, Netherlands.
Publications dans "Antigènes d'histocompatibilité" :

Martin Plasil

3 publications dans cette catégorie

Affiliations :
  • Research group Animal Immunogenomics, CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czechia.
Publications dans "Antigènes d'histocompatibilité" :

Petr Horin

3 publications dans cette catégorie

Affiliations :
  • Research group Animal Immunogenomics, CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czechia.
Publications dans "Antigènes d'histocompatibilité" :

Roger W Wiseman

2 publications dans cette catégorie

Affiliations :
  • Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Publications dans "Antigènes d'histocompatibilité" :

Matthew R Reynolds

2 publications dans cette catégorie

Affiliations :
  • Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
  • Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Publications dans "Antigènes d'histocompatibilité" :

Alexandre Walencik

2 publications dans cette catégorie

Affiliations :
  • Laboratoire d'Excellence (LabEx) TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France.
  • Etablissement Français du Sang (EFS) Centre Pays de la Loire, Laboratoire HLA, Nantes, France.
Publications dans "Antigènes d'histocompatibilité" :

Alice Aarnink

2 publications dans cette catégorie

Affiliations :
  • Laboratory of Histocompatibility, Centre Hospitalier Régional Universitaire, Nancy, France.
Publications dans "Antigènes d'histocompatibilité" :

Jean-Luc Taupin

2 publications dans cette catégorie

Affiliations :
  • Laboratoire d'Excellence (LabEx) TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France.
  • Laboratoire Jean Dausset, Laboratoire d'Immunologie et d'Histocompatibilité, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S 976, Human Immunology, Pathophysiology, Immunotherapy (HIPI), Institut de Recherche Saint-Louis Université de Paris, Hôpital Saint-Louis, Paris, France.
Publications dans "Antigènes d'histocompatibilité" :

Othmane Jadi

2 publications dans cette catégorie

Affiliations :
  • Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Publications dans "Antigènes d'histocompatibilité" :

Hancong Tang

2 publications dans cette catégorie

Affiliations :
  • College of Pharmacy, The Ohio State University, Columbus, OH.
Publications dans "Antigènes d'histocompatibilité" :

Qianqian Zhu

2 publications dans cette catégorie

Affiliations :
  • Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY.
Publications dans "Antigènes d'histocompatibilité" :

Yiwen Wang

2 publications dans cette catégorie

Affiliations :
  • Quantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, CA.
Publications dans "Antigènes d'histocompatibilité" :

Christopher A Haiman

2 publications dans cette catégorie

Affiliations :
  • Department of Preventive Medicine, University of Southern California, Los Angeles, CA.
Publications dans "Antigènes d'histocompatibilité" :

Loreall Pooler

2 publications dans cette catégorie

Affiliations :
  • The Center for Genetic Epidemiology, University of South California, Los Angeles, CA.
Publications dans "Antigènes d'histocompatibilité" :

Xin Sheng

2 publications dans cette catégorie

Affiliations :
  • Department of Preventive Medicine, University of Southern California, Los Angeles, CA.
Publications dans "Antigènes d'histocompatibilité" :

Amy Webb

2 publications dans cette catégorie

Affiliations :
  • Department of Biomedical Informatics, The Ohio State University, Columbus, OH.
Publications dans "Antigènes d'histocompatibilité" :

Marcelo C Pasquini

2 publications dans cette catégorie

Affiliations :
  • Center for International Blood and Marrow Transplant Research and Medical College of Wisconsin, Milwaukee, WI.
Publications dans "Antigènes d'histocompatibilité" :

Sources (3739 au total)

Neutral Forces and Balancing Selection Interplay to Shape the Major Histocompatibility Complex Spatial Patterns in the Striped Hamster in Inner Mongolia: Suggestive of Broad-Scale Local Adaptation.

22 07 2023
DOI: 10.3390/genes14071500 PMID: 37510404

The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the st... In this study, we investigated the immunogenic variation of the striped hamster in four wild populations in Inner Mongolia which experience a heterogeneous parasitic burden. Our goal was to identify l... We observed significant variation in parasite pressure among sites, with parasite burden showing a correlation with temperature and precipitation. Molecular analysis revealed a similar co-structure be... Overall, these results suggest a complex interplay between neutral evolutionary forces and balancing selection in shaping the spatial patterns of MHC variation. Local adaptation was not detected on a ...

Cricetinae Genetic Variation Selection, Genetic Major Histocompatibility Complex Genetic Drift +2 autres

Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing.

2023
DOI: 10.3389/fimmu.2023.1199618 PMID: 37662944

While tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not well characterized. In this study, we sought to determin... cDNA libraries were prepared from peripheral blood lymphocytes from 12 donors and sequenced by nanopore long-read sequencing. HLA reads were aligned to donor-specific reference sequences based on the ... Splice variants were rare among class I HLA genes (median exon retention rate 99%-100%), except for several... We describe a simple bioinformatic workflow to quantify allele-specific expression of HLA transcript isoforms. Further studies are warranted to characterize the repertoire of HLA transcripts expressed...

Humans Alleles Nanopore Sequencing RNA Splice Sites Histocompatibility Antigens +2 autres

Hybrid structural modeling of alloantibody binding to human leukocyte antigen with rapid and reproducible cross-linking mass spectrometry.

25 09 2023
DOI: 10.1016/j.crmeth.2023.100569 PMID: 37751693

Alloantibody recognition of donor human leukocyte antigen (HLA) is associated with poor clinical transplantation outcomes. However, the molecular and structural basis for the alloantibody-HLA interact...

Humans Histocompatibility Antigens HLA Antigens Histocompatibility Antigens Class II Isoantibodies +2 autres