Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.
Alleles
Clone Cells
Genome-Wide Association Study
Graft vs Host Disease
/ genetics
Graft vs Leukemia Effect
/ genetics
HLA-A Antigens
/ genetics
HLA-B Antigens
/ genetics
HLA-C Antigens
/ genetics
Humans
Minor Histocompatibility Antigens
/ genetics
Polymorphism, Single Nucleotide
Protein Binding
Stem Cell Transplantation
T-Lymphocytes
/ immunology
Transplantation, Homologous
Graft-versus-Leukemia effect
HLA class I
allogeneic stem cell transplantation
graft versus host disease
hematological diseases
minor histocompatibility antigens
whole genome association scanning
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
11
2019
accepted:
23
03
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
2
4
2021
Statut:
epublish
Résumé
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor T cells recognizing polymorphic peptides, which are presented on the cell surface by HLA molecules and result from single nucleotide polymorphism alleles that are disparate between patient and donor. Identification of polymorphic HLA-binding peptides, designated minor histocompatibility antigens, has been a laborious procedure, and the number and scope for broad clinical use of these antigens therefore remain limited. Here, we present an optimized whole genome association approach for discovery of HLA class I minor histocompatibility antigens. T cell clones isolated from patients who responded to donor lymphocyte infusions after HLA-matched allogeneic stem cell transplantation were tested against a panel of 191 EBV-transformed B cells, which have been sequenced by the 1000 Genomes Project and selected for expression of seven common HLA class I alleles (HLA-A
Identifiants
pubmed: 32362897
doi: 10.3389/fimmu.2020.00659
pmc: PMC7180171
doi:
Substances chimiques
HLA-A Antigens
0
HLA-B Antigens
0
HLA-C Antigens
0
Minor Histocompatibility Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
659Informations de copyright
Copyright © 2020 Fuchs, Honders, van der Meijden, Adriaans, van der Lee, Pont, Monajemi, Kielbasa, ’t Hoen, van Bergen, Falkenburg and Griffioen.
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