Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by
APOBEC
CD8 T cell
HIV
cellular immunotherapy
cynomolgus macaque
epitope
minor histocompatibility antigen (mHAg)
non-human primate (NHP)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
07
2020
accepted:
08
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
16
6
2021
Statut:
epublish
Résumé
Allogeneic hematopoietic stem cell transplants can lead to dramatic reductions in human immunodeficiency virus (HIV) reservoirs. This effect is partially mediated by donor T cells recognizing lymphocyte-expressed minor histocompatibility antigens (mHAgs). The potential to mark malignant and latently infected cells for destruction makes mHAgs attractive targets for cellular immunotherapies. However, testing such HIV reservoir reduction strategies will likely require preclinical studies in non-human primates (NHPs). In this study, we used a combination of alloimmunization, whole exome sequencing, and bioinformatics to identify an mHAg in Mauritian cynomolgus macaques (MCMs). We mapped the minimal optimal epitope to a 10-mer peptide (SW10) in apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3C (APOBEC3C) and determined the major histocompatibility complex class I restriction element as Mafa-A1
Identifiants
pubmed: 33193411
doi: 10.3389/fimmu.2020.586251
pmc: PMC7649366
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Minor Histocompatibility Antigens
0
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
586251Subventions
Organisme : NIH HHS
ID : R24 OD021322
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIH HHS
ID : P51 OD011106
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118495
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR020141
Pays : United States
Organisme : NCRR NIH HHS
ID : C06 RR015459
Pays : United States
Organisme : Wellcome Trust
ID : 100326/Z/12/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Weinfurter, Graham, Ericsen, Matschke, Llewellyn-Lacey, Price, Wiseman and Reynolds.
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