The nuts and bolts of the Haloferax CRISPR-Cas system I-B.
Archaea
CRISPR-Cas
CRISPRi
Haloarchaea
self-targeting
type I-B
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
14
4
2018
medline:
22
11
2019
entrez:
14
4
2018
Statut:
ppublish
Résumé
Invading genetic elements pose a constant threat to prokaryotic survival, requiring an effective defence. Eleven years ago, the arsenal of known defence mechanisms was expanded by the discovery of the CRISPR-Cas system. Although CRISPR-Cas is present in the majority of archaea, research often focuses on bacterial models. Here, we provide a perspective based on insights gained studying CRISPR-Cas system I-B of the archaeon Haloferax volcanii. The system relies on more than 50 different crRNAs, whose stability and maintenance critically depend on the proteins Cas5 and Cas7, which bind the crRNA and form the Cascade complex. The interference machinery requires a seed sequence and can interact with multiple PAM sequences. H. volcanii stands out as the first example of an organism that can tolerate autoimmunity via the CRISPR-Cas system while maintaining a constitutively active system. In addition, the H. volcanii system was successfully developed into a tool for gene regulation.
Identifiants
pubmed: 29649958
doi: 10.1080/15476286.2018.1460994
pmc: PMC6546412
doi:
Substances chimiques
CRISPR-Associated Proteins
0
RNA, Archaeal
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
469-480Références
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