The AAA + ATPase Thorase is neuroprotective against ischemic injury.

ATPases Associated with Diverse Cellular Activities / genetics Adenosine Triphosphatases Animals Brain Ischemia / genetics Cells, Cultured Female Gene Deletion Glucose / metabolism Infarction, Middle Cerebral Artery / genetics Ischemic Preconditioning Male Mice Neurons / metabolism Neuroprotection Oxygen / metabolism Stroke / genetics Up-Regulation
AAA + ATPase ATAD1 neuroprotection preconditioning stroke

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
09 2019
Historique:
pubmed: 17 4 2018
medline: 27 5 2020
entrez: 17 4 2018
Statut: ppublish

Résumé

Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection against glutamate excitotoxicity and experimental stroke. The proteins that mediate neuroprotection are relatively unknown and under discovery. Here we find that the expression of the AAA + ATPase Thorase is induced by preconditioning stimulation both in vitro and in vivo. Thorase provides neuroprotection in an ATP-dependent manner against oxygen-glucose deprivation (OGD) neurotoxicity or glutamate N-Methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in vitro. Knock-down of Thorase prevents the establishment of preconditioning induced neuroprotection against OGD or NMDA neurotoxicity. Transgenic overexpression of Thorase provides neuroprotection in vivo against middle cerebral artery occlusion (MCAO)-induced stroke in mice, while genetic deletion of Thorase results in increased injury in vivo following stroke. These results define Thorase as a neuroprotective protein and understanding Thorase signaling could offer a new therapeutic strategy for the treatment of neurologic disorders.

Identifiants

DOI: 10.1177/0271678X18769770 PMID: 29658368 PMC: PMC6727130
pubmed: 29658368
doi: 10.1177/0271678X18769770
pmc: PMC6727130
doi:

Substances chimiques

Adenosine Triphosphatases EC 3.6.1.-
ATAD1 protein, mouse EC 3.6.1.3
ATPases Associated with Diverse Cellular Activities EC 3.6.4.-
Glucose IY9XDZ35W2
Oxygen S88TT14065

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1836-1848

Subventions

Organisme : NIA NIH HHS
ID : R01 AG029368
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS067525
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS067525
Pays : United States

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Auteurs

Jianmin Zhang (J)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
3 Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China.

Jia Yang (J)

3 Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China.

Huaishan Wang (H)

3 Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China.
ORCID: 0000-0002-8686-4357

Omar Sherbini (O)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Matthew J Keuss (MJ)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

George Ke Umanah (GK)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Emily Ling-Lin Pai (EL)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Zhikai Chi (Z)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Kaisa Ma Paldanius (KM)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Wei He (W)

3 Department of Immunology, Research Center on Pediatric Development and Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China.

Hong Wang (H)

4 Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University Baltimore, MD, USA.

Shaida A Andrabi (SA)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Ted M Dawson (TM)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
4 Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University Baltimore, MD, USA.
5 Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University Baltimore, MD, USA.

Valina L Dawson (VL)

1 Neuroregeneration and Stem Cell Programs Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
2 Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
4 Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University Baltimore, MD, USA.
6 Physiology, School of Medicine, Johns Hopkins University Baltimore, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines AAA › ATPases associated with diverse cellular activities › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Adenosine triphosphatases › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Eucaryotes › Animaux › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Cellules › Cellules cultivées › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus encéphalique › Infarctus cérébral › Infarctus du territoire de l'artère cérébrale moyenne › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Techniques d'investigation › Préconditionnement ischémique › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Cellules › Neurones › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › The AAA + ATPase Thorase is neuroprotective...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › The AAA + ATPase Thorase is neuroprotective...