Four new phenolic constituents from the rhizomes of Gastrodia elata Blume.
Animals
Benzyl Alcohols
/ chemistry
Cell Death
/ drug effects
Cell Line
Drug Evaluation, Preclinical
/ methods
Drugs, Chinese Herbal
/ chemistry
Gastrodia
/ chemistry
Glucosides
/ chemistry
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Neurons
/ drug effects
Neuroprotective Agents
/ chemistry
Oxidopamine
/ toxicity
Phenols
/ chemistry
Plant Extracts
/ chemistry
Rhizome
/ chemistry
-(4-hydroxybenzyl) adenosine
Blume
Phenolics
grossamide
neuroprotective effects
Journal
Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
pubmed:
21
4
2018
medline:
23
7
2019
entrez:
21
4
2018
Statut:
ppublish
Résumé
Four new gastrodin derivatives containing a trans-cinnamoyl unit (1-4) and nine known compounds (5-13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC
Identifiants
pubmed: 29676594
doi: 10.1080/14786419.2018.1460836
doi:
Substances chimiques
Benzyl Alcohols
0
Drugs, Chinese Herbal
0
Glucosides
0
Neuroprotective Agents
0
Phenols
0
Plant Extracts
0
gastrodin
5YS9U2W3RQ
Oxidopamine
8HW4YBZ748
Types de publication
Journal Article
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM