The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Aged
Animals
Apoptosis
Carcinoma, Hepatocellular
/ chemically induced
Cell Line, Tumor
Cell Proliferation
Cohort Studies
Diethylnitrosamine
/ adverse effects
Disease Models, Animal
Disease Progression
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Gene Knockout Techniques
Hep G2 Cells
Humans
Liver Neoplasms
/ chemically induced
Male
Mice
Mice, Transgenic
Peroxiredoxins
/ genetics
Reactive Oxygen Species
/ metabolism
Survival Analysis
HCC
PRDX4
cell death
inflammation
oxidative stress
Journal
Antioxidants & redox signaling
ISSN: 1557-7716
Titre abrégé: Antioxid Redox Signal
Pays: United States
ID NLM: 100888899
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
pubmed:
25
4
2018
medline:
25
6
2020
entrez:
25
4
2018
Statut:
ppublish
Résumé
Peroxiredoxin 4 (PRDX4) is a member of the peroxiredoxin family of antioxidant enzymes. Previously, we reported that PRDX4 can restrain the initiation and progression of nonalcoholic steatohepatitis by reducing local and systemic reactive oxygen species (ROS) levels. Oxidative stress is recognized as a key factor in hepatocarcinogenesis, and a high ROS level has also been found in hepatocellular carcinoma (HCC). Here, our aim is to investigate roles of PRDX4 in the initiation and progression of HCC. In this study, for hepatocarcinogenesis, wild-type (WT), PRDX4 knockout (PRDX4
Identifiants
pubmed: 29687726
doi: 10.1089/ars.2017.7426
doi:
Substances chimiques
Reactive Oxygen Species
0
Diethylnitrosamine
3IQ78TTX1A
PRDX4 protein, human
EC 1.11.1.15
Peroxiredoxins
EC 1.11.1.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM