Striatopallidal neurons control avoidance behavior in exploratory tasks.
Animals
Anxiety Disorders
Avoidance Learning
/ physiology
Brain
/ metabolism
Cell Line
Corpus Striatum
/ metabolism
Female
Gray Matter
/ metabolism
Habits
Inhibition, Psychological
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons
/ metabolism
Optogenetics
/ methods
Receptors, Dopamine D2
/ genetics
Stereotypic Movement Disorder
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
25
07
2017
accepted:
19
02
2018
revised:
05
02
2018
pubmed:
27
4
2018
medline:
15
12
2020
entrez:
27
4
2018
Statut:
ppublish
Résumé
The dorsal striatum has been linked to decision-making under conflict, but the mechanism by which striatal neurons contribute to approach-avoidance conflicts remains unclear. We hypothesized that striatopallidal dopamine D2 receptor (D2R)-expressing neurons promote avoidance, and tested this hypothesis in two exploratory approach-avoidance conflict paradigms in mice: the elevated zero maze and open field. Genetic elimination of D2Rs on striatopallidal neurons (iMSNs), but not other neural populations, increased avoidance of the open areas in both tasks, in a manner that was dissociable from global changes in movement. Population calcium activity of dorsomedial iMSNs was disrupted in mice lacking D2Rs on iMSNs, suggesting that disrupted output of iMSNs contributes to heightened avoidance behavior. Consistently, artificial disruption of iMSN output with optogenetic stimulation heightened avoidance of open areas of these tasks, while inhibition of iMSN output reduced avoidance. We conclude that dorsomedial striatal iMSNs control approach-avoidance conflicts in exploratory tasks, and highlight this neural population as a potential target for reducing avoidance in anxiety disorders.
Identifiants
pubmed: 29695836
doi: 10.1038/s41380-018-0051-3
pii: 10.1038/s41380-018-0051-3
pmc: PMC6202282
mid: NIHMS944711
doi:
Substances chimiques
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
491-505Subventions
Organisme : Intramural NIH HHS
ID : Z99 DK999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075096-01
Pays : United States
Commentaires et corrections
Type : ErratumIn
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