Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection.


Journal

Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139

Informations de publication

Date de publication:
01 04 2019
Historique:
pubmed: 2 5 2018
medline: 12 9 2020
entrez: 2 5 2018
Statut: epublish

Résumé

Hepatitis A virus (HAV) and hepatitis E virus (HEV) cause acute, self-limiting hepatic infections that are usually spread by the fecal-oral route in humans. Naturally occurring and experimental infections are possible in a variety of nonhuman primates and, in the case of HEV, a number of other species. Many advances in understanding the pathogenesis of these viruses have come from studies in experimental animals. In general, animals infected with these viruses recapitulate the histologic lesions seen in infected humans, but typically with less severe clinical and histopathological manifestations. This review describes the histopathologic changes associated with HAV and HEV infection in humans and experimental animals.

Identifiants

pubmed: 29712683
pii: cshperspect.a033456
doi: 10.1101/cshperspect.a033456
pmc: PMC6444697
pii:
doi:

Types de publication

Comparative Study Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.

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Auteurs

John M Cullen (JM)

Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27607.

Stanley M Lemon (SM)

Lineberger Comprehensive Cancer Center, Departments of Medicine and Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7030.

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Classifications MeSH