Changes in bone metabolism after gastric cancer surgery in male patients: a prospective observational study.
Absorptiometry, Photon
Aged
Alkaline Phosphatase
/ blood
Bone Density
Bone Diseases, Metabolic
/ epidemiology
Bone and Bones
/ metabolism
Calcitriol
/ blood
Estradiol
/ blood
Gastrectomy
/ adverse effects
Humans
Male
Middle Aged
Osteoporosis
/ etiology
Postoperative Complications
/ blood
Prospective Studies
Stomach Neoplasms
/ surgery
Vitamin D
/ analogs & derivatives
Bone mineral density
Gastrectomy
Osteoporosis
T score
Journal
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
ISSN: 1436-3305
Titre abrégé: Gastric Cancer
Pays: Japan
ID NLM: 100886238
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
04
03
2018
accepted:
04
05
2018
pubmed:
12
5
2018
medline:
16
4
2019
entrez:
12
5
2018
Statut:
ppublish
Résumé
Several retrospective studies have shown that bone disorders occur after gastric cancer surgery. This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer. We prospectively enrolled 39 men with early gastric cancer who underwent gastrectomy. We excluded women to avoid the effects of menopause. We employed dual energy X-ray absorptiometry (DEXA) to measure bone mineral density (BMD) of the lumbar spine. DEXA was performed before and 1 and 2 years after surgery. The serum levels of alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D [1,25(OH) DEXA revealed that BMD significantly decreased by 0.036 ± 0.033 g/cm This study showed that a significant decrease in BMD was observed for up to 24 months after gastrectomy, not only 12 months.
Sections du résumé
BACKGROUND
Several retrospective studies have shown that bone disorders occur after gastric cancer surgery. This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer.
METHODS
We prospectively enrolled 39 men with early gastric cancer who underwent gastrectomy. We excluded women to avoid the effects of menopause. We employed dual energy X-ray absorptiometry (DEXA) to measure bone mineral density (BMD) of the lumbar spine. DEXA was performed before and 1 and 2 years after surgery. The serum levels of alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D [1,25(OH)
RESULTS
DEXA revealed that BMD significantly decreased by 0.036 ± 0.033 g/cm
CONCLUSIONS
This study showed that a significant decrease in BMD was observed for up to 24 months after gastrectomy, not only 12 months.
Identifiants
pubmed: 29748875
doi: 10.1007/s10120-018-0835-9
pii: 10.1007/s10120-018-0835-9
doi:
Substances chimiques
Vitamin D
1406-16-2
Estradiol
4TI98Z838E
25-hydroxyvitamin D
A288AR3C9H
Alkaline Phosphatase
EC 3.1.3.1
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
237-243Références
Hepatogastroenterology. 2000 Sep-Oct;47(35):1498-500
pubmed: 11100386
Br J Surg. 1992 Apr;79(4):321-4
pubmed: 1576498
Hepatogastroenterology. 2007 Jul-Aug;54(77):1596-600
pubmed: 17708309
Bone. 2008 Jan;42(1):61-7
pubmed: 17942383
Gastric Cancer. 2007;10(4):228-33
pubmed: 18095078
Hepatogastroenterology. 2008 Mar-Apr;55(82-83):795-8
pubmed: 18613457
Calcif Tissue Int. 1991 Aug;49(2):101-6
pubmed: 1913287
Nat Rev Endocrinol. 2009 Aug;5(8):437-43
pubmed: 19528961
Int J Cardiol. 2013 Jun 20;166(2):385-93
pubmed: 22112679
J Steroid Biochem Mol Biol. 2013 Jul;136:224-8
pubmed: 23059471
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
Ann Surg. 2013 Jun;257(6):1039-1046
pubmed: 23665970
Osteoporos Int. 2014 Oct;25(10):2359-81
pubmed: 25182228
Cancer Res Treat. 2016 Jul;48(3):1030-6
pubmed: 27004956
Surg Today. 2017 Feb;47(2):145-150
pubmed: 27226020
Asian J Surg. 2017 Nov;40(6):470-474
pubmed: 27546020
JAMA Oncol. 2017 Apr 1;3(4):524-548
pubmed: 27918777
Oncologist. 2017 May;22(5):592-600
pubmed: 28341762
Jpn J Surg. 1986 Mar;16(2):98-105
pubmed: 3723890
J Clin Invest. 1981 Feb;67(2):328-35
pubmed: 7462421
J Bone Miner Res. 1994 Aug;9(8):1137-41
pubmed: 7976495
Surg Today. 1994;24(4):295-8
pubmed: 8038501
Cancer. 1993 Dec 1;72(11):3174-8
pubmed: 8242540
Calcif Tissue Int. 1993 Dec;53(6):370-7
pubmed: 8293349
J Clin Endocrinol Metab. 1995 Dec;80(12):3689-98
pubmed: 8530621
Scand J Gastroenterol. 1997 Nov;32(11):1090-5
pubmed: 9399388
N Engl J Med. 1998 Aug 27;339(9):599-603
pubmed: 9718379