Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat.
Metabolite determination
carboxylesterase
high-performance liquid chromatography
hydrolysis
loteprednol etabonate
rat plasma
Journal
Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
pubmed:
22
5
2018
medline:
25
4
2019
entrez:
22
5
2018
Statut:
ppublish
Résumé
Loteprednol etabonate (LE) is a soft corticosteroid with two labile ester bonds at 17α- and 17β-positions. Its corticosteroidal activity disappears upon hydrolysis of either ester bond. Hydrolysis of both ester bonds produces the inactive metabolite, Δ
Identifiants
pubmed: 29781759
doi: 10.1080/00498254.2018.1479803
doi:
Substances chimiques
Paraoxon
Q9CX8P80JW
Loteprednol Etabonate
YEH1EZ96K6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM