GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.
A-type K+ current
GSK3β
Kv4.2
personalized medicine
somatosensory cortex
spike timing-dependent plasticity
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
04
10
2017
revised:
15
01
2018
accepted:
07
02
2018
pubmed:
24
5
2018
medline:
17
7
2020
entrez:
24
5
2018
Statut:
ppublish
Résumé
Spike timing-dependent plasticity (STDP) is a form of activity-dependent remodeling of synaptic strength that underlies memory formation. Despite its key role in dictating learning rules in the brain circuits, the molecular mechanisms mediating STDP are still poorly understood. Here, we show that spike timing-dependent long-term depression (tLTD) and A-type K+ currents are modulated by pharmacological agents affecting the levels of active glycogen-synthase kinase 3 (GSK3) and by GSK3β knockdown in layer 2/3 of the mouse somatosensory cortex. Moreover, the blockade of A-type K+ currents mimics the effects of GSK3 up-regulation on tLTD and occludes further changes in synaptic strength. Pharmacological, immunohistochemical and biochemical experiments revealed that GSK3β influence over tLTD induction is mediated by direct phosphorylation at Ser-616 of the Kv4.2 subunit, a molecular determinant of A-type K+ currents. Collectively, these results identify the functional interaction between GSK3β and Kv4.2 channel as a novel mechanism for tLTD modulation providing exciting insight into the understanding of GSK3β role in synaptic plasticity.
Identifiants
pubmed: 29790931
pii: 4904064
doi: 10.1093/cercor/bhy042
pmc: PMC6677919
doi:
Substances chimiques
Shal Potassium Channels
0
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Gsk3b protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1851-1865Subventions
Organisme : NIDA NIH HHS
ID : R01 DA029091
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095995
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111107
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Références
Curr Drug Targets. 2006 Nov;7(11):1377-88
pubmed: 17100578
Neurobiol Dis. 2003 Aug;13(3):177-90
pubmed: 12901832
Trends Neurosci. 2007 Apr;30(4):142-9
pubmed: 17324475
Cereb Cortex. 2009 Dec;19(12):2959-69
pubmed: 19363149
J Neurochem. 2007 Aug;102(4):1105-14
pubmed: 17484726
Science. 2015 Nov 27;350(6264):aac9462
pubmed: 26612957
J Neurosci. 2009 May 20;29(20):6558-67
pubmed: 19458226
Neuron. 2000 Jul;27(1):45-56
pubmed: 10939330
Nat Genet. 2004 Feb;36(2):131-7
pubmed: 14745448
Neuroscientist. 2008 Jun;14(3):276-86
pubmed: 18413784
Nat Neurosci. 2001 Nov;4(11):1071-8
pubmed: 11593232
Front Mol Neurosci. 2012 Mar 15;5:33
pubmed: 22435049
J Neurosci. 2006 Oct 25;26(43):11001-13
pubmed: 17065442
Front Mol Neurosci. 2012 Feb 15;5:13
pubmed: 22363262
Mol Cell Biol. 2000 Dec;20(24):9356-63
pubmed: 11094086
EMBO J. 1990 Aug;9(8):2431-8
pubmed: 2164470
Neuron. 2004 Oct 14;44(2):351-64
pubmed: 15473972
Neuroscience. 1991;41(2-3):365-79
pubmed: 1870696
Chem Rev. 2001 Aug;101(8):2527-40
pubmed: 11749387
Am J Physiol Cell Physiol. 2013 Apr 15;304(8):C801-7
pubmed: 23426971
Neuropharmacology. 2009 Jun;56(8):1116-23
pubmed: 19328817
J Neurosci. 1992 Jan;12(1):319-29
pubmed: 1729440
J Cell Sci. 2003 Apr 1;116(Pt 7):1175-86
pubmed: 12615961
J Neurosci. 2007 Sep 12;27(37):9835-45
pubmed: 17855598
Neuroscience. 2015 Dec 17;311:322-40
pubmed: 26597763
J Neurosci. 2006 Nov 22;26(47):12143-51
pubmed: 17122039
Nat Biotechnol. 2016 Feb;34(2):199-203
pubmed: 26689543
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7789-93
pubmed: 8356085
J Biol Chem. 2000 Feb 25;275(8):5337-46
pubmed: 10681507
Pharmacol Ther. 2015 Apr;148:114-31
pubmed: 25435019
Elife. 2017 May 16;6:
pubmed: 28509666
Cell. 1991 Feb 8;64(3):573-84
pubmed: 1846781
Pharmacol Res. 2016 Feb;104:97-107
pubmed: 26687096
J Neurosci. 2004 Apr 7;24(14):3643-54
pubmed: 15071113
J Neurosci. 2004 Sep 8;24(36):7903-15
pubmed: 15356203
Neuroscience. 2014 Jan 31;258:270-9
pubmed: 24269937
Neuron. 2008 Nov 26;60(4):657-71
pubmed: 19038222
IUBMB Life. 2009 May;61(5):516-21
pubmed: 19391164
Biochem J. 2007 Dec 15;408(3):297-315
pubmed: 17850214
J Neurophysiol. 2002 Jul;88(1):507-13
pubmed: 12091572
Am J Physiol Cell Physiol. 2006 Mar;290(3):C852-61
pubmed: 16251476
Trends Neurosci. 2016 Jan;39(1):26-39
pubmed: 26726120
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10831-6
pubmed: 12136127
J Neurochem. 2008 Mar;104(6):1433-9
pubmed: 18088381
Pain. 2012 Mar;153(3):562-74
pubmed: 22188869
J Neurosci. 2010 Apr 7;30(14):5092-101
pubmed: 20371829
PLoS One. 2014 Jan 03;9(1):e84086
pubmed: 24404150
J Biol Chem. 1998 Aug 7;273(32):19929-32
pubmed: 9685326
Nat Neurosci. 2008 Jul;11(7):744-5
pubmed: 18516036
Biol Psychiatry. 2014 Feb 1;75(3):198-206
pubmed: 24041505
Physiol Rep. 2014 Mar 27;2(3):e00271
pubmed: 24760524
Trends Biochem Sci. 2004 Feb;29(2):95-102
pubmed: 15102436
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10144-9
pubmed: 12114547
J Neurosci. 2014 Nov 26;34(48):15888-97
pubmed: 25429131
Neurosci Lett. 2006 Dec 1;409(2):134-9
pubmed: 17046157
Science. 2005 Nov 4;310(5749):810-5
pubmed: 16272113
Nature. 1997 Jun 26;387(6636):869-75
pubmed: 9202119
Nat Neurosci. 2012 Mar 25;15(5):746-53
pubmed: 22446881
Biochem J. 2001 Oct 1;359(Pt 1):1-16
pubmed: 11563964
J Biol Chem. 1992 Aug 25;267(24):16878-82
pubmed: 1324914
Neuron. 2007 Mar 1;53(5):703-17
pubmed: 17329210
J Neurosci. 1998 May 15;18(10):3521-8
pubmed: 9570783
Exp Neurol. 2014 Feb;252:28-36
pubmed: 24269865
Trends Neurosci. 1990 Mar;13(3):99-104
pubmed: 1691879
Neurobiol Aging. 2015 Feb;36(2):886-900
pubmed: 25541422
Nat Neurosci. 2011 May;14(5):545-7
pubmed: 21441921
PLoS One. 2015 Nov 13;10(11):e0142554
pubmed: 26565809
Neuron. 2013 Apr 10;78(1):28-48
pubmed: 23583106
Neuron. 2017 Mar 22;93(6):1375-1387.e2
pubmed: 28262417
J Neurochem. 2000 Dec;75(6):2277-87
pubmed: 11080179
Prog Neurobiol. 2001 Nov;65(4):391-426
pubmed: 11527574
J Neurosci. 2005 Oct 5;25(40):9185-94
pubmed: 16207878
Neurochem Res. 2017 May;42(5):1366-1374
pubmed: 28247332
Neurosci Bull. 2014 Jun;30(3):505-14
pubmed: 24526657
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):100-114
pubmed: 28449557
J Physiol. 2013 May 15;591(10):2419-27
pubmed: 23440961
Neurobiol Dis. 1998 Aug;5(2):81-8
pubmed: 9746905
Neuron. 2003 Aug 14;39(4):641-54
pubmed: 12925278
Sci Rep. 2017 Apr 07;7:46122
pubmed: 28387234
J Cell Sci. 1998 May;111 ( Pt 10):1351-61
pubmed: 9570753
Alcohol Clin Exp Res. 2013 Dec;37(12):2074-85
pubmed: 23889304
Front Mol Neurosci. 2012 Jul 16;5:80
pubmed: 22811658
Neuron. 2011 Dec 8;72(5):819-31
pubmed: 22153377
PLoS One. 2015 Feb 06;10(2):e0117246
pubmed: 25659151
Neuropharmacology. 2017 May 1;117:49-60
pubmed: 28126496
Front Synaptic Neurosci. 2010 Jun 17;2:18
pubmed: 21423504
J Neurophysiol. 2016 May 1;115(5):2317-29
pubmed: 26864770
Nature. 1987 Apr 16-22;326(6114):694-7
pubmed: 3561512
Neuron. 2012 Aug 23;75(4):556-71
pubmed: 22920249
Endocrine. 2016 Sep;53(3):681-8
pubmed: 26547215
Pflugers Arch. 2014 May;466(5):903-14
pubmed: 24046152
J Neurophysiol. 1998 Oct;80(4):1765-74
pubmed: 9772237
Front Mol Neurosci. 2011 Aug 09;4:16
pubmed: 21886606
Annu Rev Neurosci. 2015 Jul 8;38:195-219
pubmed: 25897875
Front Mol Neurosci. 2011 Nov 16;4:40
pubmed: 22110425
Eur J Cell Biol. 2000 Apr;79(4):252-60
pubmed: 10826493
J Neurochem. 1994 Jul;63(1):245-55
pubmed: 7515946
Neuron. 2016 Mar 2;89(5):1100-9
pubmed: 26898776
J Neurosci. 2006 Apr 19;26(16):4166-77
pubmed: 16624937
J Neurosci. 2002 Dec 1;22(23):10106-15
pubmed: 12451111
Cancer Res. 2004 Jul 1;64(13):4394-9
pubmed: 15231645
Nat Neurosci. 2016 Sep;19(9):1218-24
pubmed: 27399842
Nature. 1995 Dec 21-28;378(6559):785-9
pubmed: 8524413
Br J Pharmacol. 2008 Mar;153 Suppl 1:S428-37
pubmed: 18311157
Front Mol Neurosci. 2011 Aug 26;4:17
pubmed: 21904524
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5
pubmed: 11035810