Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.
Lhx6
Lhx8
Nkx2-1
Sp9
interneurons
medial ganglionic eminence
parvalbumin
somatostatin
tangential migration
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
13
02
2018
revised:
06
05
2018
pubmed:
8
6
2018
medline:
23
9
2020
entrez:
8
6
2018
Statut:
ppublish
Résumé
Immature neurons generated by the subpallial MGE tangentially migrate to the cortex where they become parvalbumin-expressing (PV+) and somatostatin (SST+) interneurons. Here, we show that the Sp9 transcription factor controls the development of MGE-derived cortical interneurons. SP9 is expressed in the MGE subventricular zone and in MGE-derived migrating interneurons. Sp9 null and conditional mutant mice have approximately 50% reduction of MGE-derived cortical interneurons, an ectopic aggregation of MGE-derived neurons in the embryonic ventral telencephalon, and an increased ratio of SST+/PV+ cortical interneurons. RNA-Seq and SP9 ChIP-Seq reveal that SP9 regulates MGE-derived cortical interneuron development through controlling the expression of key transcription factors Arx, Lhx6, Lhx8, Nkx2-1, and Zeb2 involved in interneuron development, as well as genes implicated in regulating interneuron migration Ackr3, Epha3, and St18. Thus, Sp9 has a central transcriptional role in MGE-derived cortical interneuron development.
Identifiants
pubmed: 29878134
pii: 5033562
doi: 10.1093/cercor/bhy133
pmc: PMC6519701
doi:
Substances chimiques
RNA-Binding Proteins
0
Transcription Factors
0
Znf9 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2653-2667Subventions
Organisme : NIMH NIH HHS
ID : R01 MH094589
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089777
Pays : United States
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Références
Development. 1999 Aug;126(15):3359-70
pubmed: 10393115
J Neurosci. 2000 Aug 15;20(16):6063-76
pubmed: 10934256
BMC Dev Biol. 2001;1:4
pubmed: 11299042
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9005-10
pubmed: 12855770
J Neurosci. 2004 Mar 17;24(11):2612-22
pubmed: 15028753
J Neurosci. 2004 Jun 16;24(24):5643-8
pubmed: 15201337
Eur J Neurosci. 2005 Jun;21(11):2923-38
pubmed: 15978004
Neuron. 2005 Nov 23;48(4):591-604
pubmed: 16301176
Nat Rev Neurosci. 2006 Sep;7(9):687-96
pubmed: 16883309
J Neurosci. 2007 Mar 21;27(12):3078-89
pubmed: 17376969
J Neurosci. 2007 Jul 18;27(29):7786-98
pubmed: 17634372
Neuron. 2007 Aug 2;55(3):417-33
pubmed: 17678855
J Neurosci. 2007 Oct 10;27(41):10935-46
pubmed: 17928435
Development. 2007 Nov;134(22):4083-93
pubmed: 17965053
J Comp Neurol. 2008 Jan 1;506(1):16-29
pubmed: 17990269
Development. 2008 Apr;135(8):1559-67
pubmed: 18339674
J Comp Neurol. 2008 Sep 1;510(1):79-99
pubmed: 18613121
Eur J Neurosci. 2008 Jul;28(1):62-73
pubmed: 18662335
Neuron. 2008 Sep 11;59(5):733-45
pubmed: 18786357
J Comp Neurol. 2009 Feb 1;512(4):556-72
pubmed: 19030180
Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
pubmed: 19386638
Development. 2009 Nov;136(22):3841-51
pubmed: 19855026
J Neurosci. 2010 Feb 24;30(8):2812-23
pubmed: 20181579
J Neurosci. 2010 Feb 24;30(8):2824-34
pubmed: 20181580
Cell Adh Migr. 2010 Jul-Sep;4(3):400-8
pubmed: 20473036
Eur J Neurosci. 2010 Jun;31(12):2136-41
pubmed: 20529125
J Neurosci. 2010 Sep 8;30(36):12050-62
pubmed: 20826668
Dev Neurobiol. 2011 Jan 1;71(1):45-61
pubmed: 21154909
Neuron. 2011 Jun 9;70(5):939-50
pubmed: 21658586
Cereb Cortex. 2012 Apr;22(4):820-7
pubmed: 21693785
Science. 2011 Oct 28;334(6055):480-6
pubmed: 22034427
Nat Protoc. 2012 Mar 01;7(3):562-78
pubmed: 22383036
Cereb Cortex. 2013 Aug;23(8):1811-23
pubmed: 22710612
Science. 2013 Jan 4;339(6115):70-4
pubmed: 23180771
Neuron. 2013 Jan 9;77(1):70-82
pubmed: 23312517
Neuron. 2013 Jan 9;77(1):83-98
pubmed: 23312518
Neuron. 2014 Apr 16;82(2):350-64
pubmed: 24742460
J Neurosci. 2014 Aug 13;34(33):10906-23
pubmed: 25122892
Neuron. 2015 Jan 7;85(1):27-47
pubmed: 25569346
J Neurosci. 2015 Jun 10;35(23):8718-29
pubmed: 26063906
Cell Rep. 2015 Jul 21;12(3):482-94
pubmed: 26166575
Cell Rep. 2015 Nov 10;13(6):1090-1095
pubmed: 26526999
Cell Rep. 2016 Aug 2;16(5):1431-1444
pubmed: 27452460
Neuron. 2016 Sep 21;91(6):1260-1275
pubmed: 27657450
Neuron. 2016 Oct 5;92(1):59-74
pubmed: 27710791
Cereb Cortex. 2018 Sep 1;28(9):3278-3294
pubmed: 28981617
Cereb Cortex. 2018 Nov 1;28(11):3797-3815
pubmed: 29028947
Development. 2017 Nov 1;144(21):3867-3878
pubmed: 29089360
Cell. 2018 Jan 25;172(3):491-499.e15
pubmed: 29358049
Science. 1997 Oct 17;278(5337):474-6
pubmed: 9334308