Multi-method brain imaging reveals impaired representations of number as well as altered connectivity in adults with dyscalculia.
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
30
03
2017
revised:
01
06
2018
accepted:
04
06
2018
pubmed:
10
6
2018
medline:
28
1
2020
entrez:
10
6
2018
Statut:
ppublish
Résumé
Two hypotheses have been proposed about the etiology of neurodevelopmental learning disorders, such as dyslexia and dyscalculia: representation impairments and disrupted access to representations. We implemented a multi-method brain imaging approach to directly investigate these representation and access hypotheses in dyscalculia, a highly prevalent but understudied neurodevelopmental disorder in learning to calculate. We combined several magnetic resonance imaging methods and analyses, including univariate and multivariate analyses, functional and structural connectivity. Our sample comprised 24 adults with dyscalculia and 24 carefully matched controls. Results showed a clear deficit in the non-symbolic magnitude representations in parietal, temporal and frontal regions, as well as hyper-connectivity in visual brain regions in adults with dyscalculia. Dyscalculia in adults was thereby related to both impaired number representations and altered connectivity in the brain. We conclude that dyscalculia is related to impaired number representations as well as altered access to these representations.
Identifiants
pubmed: 29885484
pii: S1053-8119(18)30519-6
doi: 10.1016/j.neuroimage.2018.06.012
pmc: PMC6494208
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-302Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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