Cerebral oxidative metabolism mapping in four genetic mouse models of anxiety and mood disorders.

Amygdala / physiopathology Animals Anxiety / physiopathology Anxiety Disorders / physiopathology Behavior, Animal / physiology Disease Models, Animal Hypothalamus / physiopathology Mice, Knockout Mood Disorders / physiopathology Neural Pathways / physiopathology Oxidative Stress / physiology Septal Nuclei / physiopathology
Animal model Cytochrome oxidase histochemistry Depression Genetically modified mice Oxidative metabolism

Journal

Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872

Informations de publication

Date de publication:
01 01 2019
Historique:
received: 24 04 2018
revised: 29 05 2018
accepted: 29 05 2018
pubmed: 11 6 2018
medline: 17 4 2019
entrez: 11 6 2018
Statut: ppublish

Résumé

The psychopathology of depression is highly complex and the outcome of studies on animal models is divergent. In order to find brain regions that could be metabolically distinctively active across a variety of mouse depression models and to compare the interconnectivity of brain regions of wild-type and such genetically modified mice, histochemical mapping of oxidative metabolism was performed by the measurement of cytochrome oxidase activity. We included mice with the heterozygous knockout of the vesicular glutamate transporter (VGLUT

Identifiants

DOI: 10.1016/j.bbr.2018.05.031 PMID: 29885846
pubmed: 29885846
pii: S0166-4328(18)30583-7
doi: 10.1016/j.bbr.2018.05.031
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

435-443

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Denis Matrov (D)

Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Ravila 14A Chemicum, 50411 Tartu, Estonia; Department of Neuroscience, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Tanel Kaart (T)

Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 1, 51014 Tartu, Estonia.

Laurence Lanfumey (L)

Centre de Psychiatrie et Neuroscience, INSERM U 894, 2 ter rue d'Alésia, 75014 Paris, France.

Rafael Maldonado (R)

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

Trevor Sharp (T)

Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, United Kingdom.

Rosa M Tordera (RM)

Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain.

Paul A Kelly (PA)

Centre for Cognitive and Neural Systems, University of Edinburgh, Scotland, United Kingdom.

Bill Deakin (B)

Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.

Jaanus Harro (J)

Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Ravila 14A Chemicum, 50411 Tartu, Estonia. Electronic address: jaanus.harro@ut.ee.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Eucaryotes › Animaux › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Cerebral oxidative metabolism mapping in four...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Septum du cerveau › Noyaux du septum › Cerebral oxidative metabolism mapping in four...