Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing.

Animals Bone Regeneration / drug effects Drug Delivery Systems Humans Purinergic P1 Receptor Agonists / chemistry Wound Healing / drug effects
Adenosine receptor Bone regeneration Osteoblast Osteoclast Tissue engineering

Journal

Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523

Informations de publication

Date de publication:
06 2019
Historique:
received: 20 10 2017
revised: 08 05 2018
accepted: 12 06 2018
pubmed: 19 6 2018
medline: 30 7 2020
entrez: 19 6 2018
Statut: ppublish

Résumé

Adenosine receptor activation has been investigated as a potential therapeutic approach to heal bone. Bone has enhanced regenerative potential when influenced by either direct or indirect adenosine receptor agonism. As investigators continue to elucidate how adenosine influences bone cell homeostasis at the cellular and molecular levels, a small but growing body of literature has reported successful in vivo applications of adenosine delivery. This review summarizes the role adenosine receptor ligation plays in osteoblast and osteoclast biology and remodeling/regeneration. It also reports on all the modalities described in the literature at this point for delivery of adenosine through in vivo models for bone healing and regeneration.

Identifiants

DOI: 10.1016/j.addr.2018.06.010 PMID: 29913176
pubmed: 29913176
pii: S0169-409X(18)30149-2
doi: 10.1016/j.addr.2018.06.010
pii:
doi:

Substances chimiques

Purinergic P1 Receptor Agonists 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

240-247

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Christopher D Lopez (CD)

Hansjörg Wyss Department of Plastic Surgery at New York University School of Medicine, 307 East 33rd Street, New York, NY 10016, United States; Division of Translational Medicine at New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States; Department of Biomaterials & Biomimetics at New York University College of Dentistry, 433 First Avenue, New York, NY 10010, United States; Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, United States. Electronic address: christopher.lopez2@nyumc.org.

Jonathan M Bekisz (JM)

Hansjörg Wyss Department of Plastic Surgery at New York University School of Medicine, 307 East 33rd Street, New York, NY 10016, United States.

Carmen Corciulo (C)

Division of Translational Medicine at New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States.

Aranzazu Mediero (A)

Division of Translational Medicine at New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States; Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain.

Paulo G Coelho (PG)

Hansjörg Wyss Department of Plastic Surgery at New York University School of Medicine, 307 East 33rd Street, New York, NY 10016, United States; Department of Biomaterials & Biomimetics at New York University College of Dentistry, 433 First Avenue, New York, NY 10010, United States.

Lukasz Witek (L)

Department of Biomaterials & Biomimetics at New York University College of Dentistry, 433 First Avenue, New York, NY 10010, United States.

Roberto L Flores (RL)

Hansjörg Wyss Department of Plastic Surgery at New York University School of Medicine, 307 East 33rd Street, New York, NY 10016, United States.

Bruce N Cronstein (BN)

Division of Translational Medicine at New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Local delivery of adenosine receptor agonists...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › Local delivery of adenosine receptor agonists...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Local delivery of adenosine receptor agonists...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Local delivery of adenosine receptor agonists...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Agonistes purinergiques › Agonistes des récepteurs purinergiques P1 › Local delivery of adenosine receptor agonists...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Local delivery of adenosine receptor agonists...