Titre : Effets physiologiques des médicaments

Effets physiologiques des médicaments : Questions médicales fréquentes

Nom anglais: Physiological Effects of Drugs

Descriptor UI: D045505

Tree Number: D27.505.696

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment évaluer les effets d'un médicament sur le corps ?

Des tests cliniques et des biomarqueurs sont utilisés pour évaluer les effets.
Évaluation clinique Biomarqueurs
#2

Quels tests sont utilisés pour détecter les effets secondaires ?

Les tests sanguins, les examens d'imagerie et les questionnaires sont courants.
Tests sanguins Effets secondaires
#3

Comment identifier une réaction allergique à un médicament ?

Des tests cutanés et des antécédents médicaux aident à identifier les allergies.
Réaction allergique Tests cutanés
#4

Quels signes indiquent une surdose médicamenteuse ?

Les symptômes incluent confusion, nausées, et troubles respiratoires.
Surdose Symptômes
#5

Comment diagnostiquer une interaction médicamenteuse ?

L'analyse des antécédents médicamenteux et des tests de laboratoire sont essentiels.
Interactions médicamenteuses Antécédents médicaux

Symptômes 5

#1

Quels symptômes peuvent indiquer un effet indésirable ?

Les symptômes incluent fatigue, vertiges, et troubles gastro-intestinaux.
Effets indésirables Symptômes
#2

Comment reconnaître une toxicité médicamenteuse ?

Des signes comme des éruptions cutanées, des douleurs abdominales, et des vomissements.
Toxicité médicamenteuse Éruptions cutanées
#3

Quels symptômes sont liés aux antidépresseurs ?

Les effets incluent des changements d'humeur, des troubles du sommeil, et des nausées.
Antidépresseurs Troubles du sommeil
#4

Quels signes indiquent une réaction au traitement anticancéreux ?

Les signes incluent fatigue extrême, perte de poids, et infections fréquentes.
Traitement anticancéreux Fatigue
#5

Quels symptômes peuvent résulter d'analgésiques ?

Les analgésiques peuvent causer constipation, somnolence, et nausées.
Analgésiques Constipation

Prévention 5

#1

Comment prévenir les effets indésirables des médicaments ?

Une prescription appropriée et un suivi régulier aident à minimiser les risques.
Effets indésirables Suivi médical
#2

Quels conseils pour éviter les interactions médicamenteuses ?

Informer le médecin de tous les médicaments pris et éviter l'automédication.
Interactions médicamenteuses Automédication
#3

Comment la vaccination prévient-elle les maladies ?

Les vaccins stimulent le système immunitaire pour prévenir les infections.
Vaccination Système immunitaire
#4

Quels sont les moyens de prévenir la résistance aux antibiotiques ?

Utiliser les antibiotiques judicieusement et compléter les traitements prescrits.
Résistance aux antibiotiques Traitements prescrits
#5

Comment le mode de vie influence-t-il l'efficacité des médicaments ?

Une alimentation saine et l'exercice régulier peuvent améliorer l'efficacité.
Mode de vie Efficacité des médicaments

Traitements 5

#1

Comment les médicaments modifient-ils la pression artérielle ?

Les antihypertenseurs abaissent la pression en relaxant les vaisseaux sanguins.
Antihypertenseurs Pression artérielle
#2

Quels médicaments sont utilisés pour traiter l'anxiété ?

Les anxiolytiques et les antidépresseurs sont couramment prescrits.
Anxiolytiques Antidépresseurs
#3

Comment les antibiotiques agissent-ils sur les infections ?

Ils inhibent la croissance bactérienne ou tuent les bactéries responsables.
Antibiotiques Infections
#4

Quels médicaments sont utilisés pour le diabète ?

Les insulines et les médicaments oraux régulent la glycémie.
Diabète Insuline
#5

Comment les médicaments anti-inflammatoires soulagent-ils la douleur ?

Ils réduisent l'inflammation et bloquent les signaux de douleur au niveau cellulaire.
Anti-inflammatoires Douleur

Complications 5

#1

Quelles complications peuvent survenir avec les anticoagulants ?

Les complications incluent des hémorragies et des ecchymoses fréquentes.
Anticoagulants Hémorragies
#2

Quels risques sont associés aux traitements immunosuppresseurs ?

Ils augmentent le risque d'infections et de cancers secondaires.
Immunosuppresseurs Infections
#3

Comment les médicaments peuvent-ils affecter la fonction hépatique ?

Certains médicaments peuvent provoquer des hépatites médicamenteuses ou des lésions.
Fonction hépatique Hépatites médicamenteuses
#4

Quelles complications peuvent résulter des traitements anticancéreux ?

Les complications incluent la fatigue, les nausées, et les infections opportunistes.
Traitements anticancéreux Fatigue
#5

Quels effets à long terme peuvent avoir les corticostéroïdes ?

Ils peuvent entraîner une ostéoporose, un diabète et des troubles cardiovasculaires.
Corticostéroïdes Ostéoporose

Facteurs de risque 5

#1

Quels facteurs augmentent le risque d'effets indésirables ?

L'âge, le sexe, et les comorbidités peuvent augmenter le risque d'effets indésirables.
Facteurs de risque Comorbidités
#2

Comment l'alcool influence-t-il l'efficacité des médicaments ?

L'alcool peut interférer avec le métabolisme des médicaments, augmentant les effets.
Alcool Métabolisme des médicaments
#3

Quels médicaments sont à risque pour les personnes âgées ?

Les sédatifs et les anticoagulants présentent un risque accru chez les personnes âgées.
Personnes âgées Sédatifs
#4

Comment les maladies chroniques affectent-elles le traitement médicamenteux ?

Elles peuvent modifier la pharmacocinétique et augmenter le risque d'effets indésirables.
Maladies chroniques Pharmacocinétique
#5

Quels facteurs génétiques influencent la réponse aux médicaments ?

Les variations génétiques peuvent affecter le métabolisme et l'efficacité des médicaments.
Facteurs génétiques Métabolisme des médicaments
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Stuttgart, Germany." } }, { "@type": "Person", "name": "Fatima Zahra Marok", "url": "https://questionsmedicales.fr/author/Fatima%20Zahra%20Marok", "affiliation": { "@type": "Organization", "name": "Clinical Pharmacy, Saarland University, 66123 Saarbruecken, Germany." } }, { "@type": "Person", "name": "Laura Maria Fuhr", "url": "https://questionsmedicales.fr/author/Laura%20Maria%20Fuhr", "affiliation": { "@type": "Organization", "name": "Clinical Pharmacy, Saarland University, 66123 Saarbruecken, Germany." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Comprehensive Physiologically Based Pharmacokinetic Model to Assess Drug-Drug Interactions of Phenytoin.", "datePublished": "2023-10-18", "url": "https://questionsmedicales.fr/article/37896246", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3390/pharmaceutics15102486" } }, { "@type": "ScholarlyArticle", "name": "Physiologically-based pharmacokinetic model of sparsentan to evaluate drug-drug 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questionnaires sont courants." } }, { "@type": "Question", "name": "Comment identifier une réaction allergique à un médicament ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des tests cutanés et des antécédents médicaux aident à identifier les allergies." } }, { "@type": "Question", "name": "Quels signes indiquent une surdose médicamenteuse ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent confusion, nausées, et troubles respiratoires." } }, { "@type": "Question", "name": "Comment diagnostiquer une interaction médicamenteuse ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'analyse des antécédents médicamenteux et des tests de laboratoire sont essentiels." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un effet indésirable ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, vertiges, et troubles gastro-intestinaux." } }, { "@type": "Question", "name": "Comment reconnaître une toxicité médicamenteuse ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Des signes comme des éruptions cutanées, des douleurs abdominales, et des vomissements." } }, { "@type": "Question", "name": "Quels symptômes sont liés aux antidépresseurs ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les effets incluent des changements d'humeur, des troubles du sommeil, et des nausées." } }, { "@type": "Question", "name": "Quels signes indiquent une réaction au traitement anticancéreux ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Les signes incluent fatigue extrême, perte de poids, et infections fréquentes." } }, { "@type": "Question", "name": "Quels symptômes peuvent résulter d'analgésiques ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Les analgésiques peuvent causer constipation, somnolence, et nausées." } }, { "@type": "Question", "name": "Comment prévenir les effets indésirables des médicaments ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une prescription appropriée et un suivi régulier aident à minimiser les risques." } }, { "@type": "Question", "name": "Quels conseils pour éviter les interactions médicamenteuses ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Informer le médecin de tous les médicaments pris et éviter l'automédication." } }, { "@type": "Question", "name": "Comment la vaccination prévient-elle les maladies ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Les vaccins stimulent le système immunitaire pour prévenir les infections." } }, { "@type": "Question", "name": "Quels sont les moyens de prévenir la résistance aux antibiotiques ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Utiliser les antibiotiques judicieusement et compléter les traitements prescrits." } }, { "@type": "Question", "name": "Comment le mode de vie influence-t-il l'efficacité des médicaments ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation saine et l'exercice régulier peuvent améliorer l'efficacité." } }, { "@type": "Question", "name": "Comment les médicaments modifient-ils la pression artérielle ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les antihypertenseurs abaissent la pression en relaxant les vaisseaux sanguins." } }, { "@type": "Question", "name": "Quels médicaments sont utilisés pour traiter l'anxiété ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Les anxiolytiques et les antidépresseurs sont couramment prescrits." } }, { "@type": "Question", "name": "Comment les antibiotiques agissent-ils sur les infections ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Ils inhibent la croissance bactérienne ou tuent les bactéries responsables." } }, { "@type": "Question", "name": "Quels médicaments sont utilisés pour le diabète ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Les insulines et les médicaments oraux régulent la glycémie." } }, { "@type": "Question", "name": "Comment les médicaments anti-inflammatoires soulagent-ils la douleur ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Ils réduisent l'inflammation et bloquent les signaux de douleur au niveau cellulaire." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les anticoagulants ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des hémorragies et des ecchymoses fréquentes." } }, { "@type": "Question", "name": "Quels risques sont associés aux traitements immunosuppresseurs ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Ils augmentent le risque d'infections et de cancers secondaires." } }, { "@type": "Question", "name": "Comment les médicaments peuvent-ils affecter la fonction hépatique ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Certains médicaments peuvent provoquer des hépatites médicamenteuses ou des lésions." } }, { "@type": "Question", "name": "Quelles complications peuvent résulter des traitements anticancéreux ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent la fatigue, les nausées, et les infections opportunistes." } }, { "@type": "Question", "name": "Quels effets à long terme peuvent avoir les corticostéroïdes ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent entraîner une ostéoporose, un diabète et des troubles cardiovasculaires." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque d'effets indésirables ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'âge, le sexe, et les comorbidités peuvent augmenter le risque d'effets indésirables." } }, { "@type": "Question", "name": "Comment l'alcool influence-t-il l'efficacité des médicaments ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "L'alcool peut interférer avec le métabolisme des médicaments, augmentant les effets." } }, { "@type": "Question", "name": "Quels médicaments sont à risque pour les personnes âgées ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Les sédatifs et les anticoagulants présentent un risque accru chez les personnes âgées." } }, { "@type": "Question", "name": "Comment les maladies chroniques affectent-elles le traitement médicamenteux ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent modifier la pharmacocinétique et augmenter le risque d'effets indésirables." } }, { "@type": "Question", "name": "Quels facteurs génétiques influencent la réponse aux médicaments ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Les variations génétiques peuvent affecter le métabolisme et l'efficacité des médicaments." } } ] } ] }
Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

Validation scientifique effectuée le 11/07/2026

Contenu vérifié selon les dernières recommandations médicales

En savoir plus sur Dr Menir

Sous-catégories

173 au total
└─

Antipyrétiques

Antipyretics D058633 - D27.505.696.068
└─

Agents de maintien de la densité osseuse

Bone Density Conservation Agents D050071 - D27.505.696.242
└─

Hormones et agents régulant le calcium

Calcium-Regulating Hormones and Agents D000077264 - D27.505.696.260
└─

Galactogogues

Galactogogues D056669 - D27.505.696.365
└─

Substances de croissance

Growth Substances D006133 - D27.505.696.377
└─

Hormones, substituts d'hormones et antagonistes d'hormones

Hormones, Hormone Substitutes, and Hormone Antagonists D006730 - D27.505.696.399
└─

Hypoglycémiants

Hypoglycemic Agents D007004 - D27.505.696.422
└─

Facteurs immunologiques

Immunologic Factors D007155 - D27.505.696.477
└─

Agents neuromédiateurs

Neurotransmitter Agents D018377 - D27.505.696.577
└─

Substances améliorant les performances

Performance-Enhancing Substances D058573 - D27.505.696.620
└─

Agents du système nerveux périphérique

Peripheral Nervous System Agents D018373 - D27.505.696.663
└─

Sécrétagogues

Secretagogues D000078604 - D27.505.696.937
└─└─

Modulateurs d'angiogenèse

Angiogenesis Modulating Agents D043924 - D27.505.696.377.077
└─└─

Inhibiteurs de croissance

Growth Inhibitors D006131 - D27.505.696.377.450
└─└─

Facteur de croissance végétal

Plant Growth Regulators D010937 - D27.505.696.377.760
└─└─

Antihormones

Hormone Antagonists D006727 - D27.505.696.399.450
└─└─

Hormones

Hormones D006728 - D27.505.696.399.472
└─└─

Inhibiteurs des glycoside hydrolases

Glycoside Hydrolase Inhibitors D065089 - D27.505.696.422.249
└─└─

Agonistes des récepteurs de l'amyline

Amylin Receptor Agonists D065091 - D27.505.696.422.374
└─└─

Inhibiteurs de la dipeptidyl-peptidase IV

Dipeptidyl-Peptidase IV Inhibitors D054873 - D27.505.696.422.500
└─└─

Secrétagogues à l'insuline

Insulin Secretagogues D000092005 - D27.505.696.422.625
└─└─

Agonistes du PPAR gamma

PPAR-gamma Agonists D000092126 - D27.505.696.422.688
└─└─

Inhibiteurs du cotransporteur sodium-glucose de type 2

Sodium-Glucose Transporter 2 Inhibitors D000077203 - D27.505.696.422.750
└─└─

Adjuvants immunologiques

Adjuvants, Immunologic D000276 - D27.505.696.477.067
└─└─

Immunoconjugués

Immunoconjugates D018796 - D27.505.696.477.266
└─└─

Immunomodulateurs

Immunomodulating Agents D000091369 - D27.505.696.477.396
└─└─

Immunosuppresseurs

Immunosuppressive Agents D007166 - D27.505.696.477.656
└─└─

Inducteurs de l'interféron

Interferon Inducers D007369 - D27.505.696.477.828
└─└─

Antidiurétiques

Antidiuretic Agents D050034 - D27.505.696.560.249
└─└─

Antagonistes des récepteurs de l'hormone antidiurétique

Antidiuretic Hormone Receptor Antagonists D065092 - D27.505.696.560.311
└─└─

Agents anti-hyperkaliémiants

Antihyperkalemic Agents D065067 - D27.505.696.560.374
└─└─

Diurétiques

Diuretics D004232 - D27.505.696.560.500
└─└─

Agents adrénergiques

Adrenergic Agents D018663 - D27.505.696.577.050
└─└─

Agents cholinergiques

Cholinergic Agents D018678 - D27.505.696.577.120
└─└─

Agents dopaminergiques

Dopamine Agents D015259 - D27.505.696.577.150
└─└─

Agents des acides aminés excitateurs

Excitatory Amino Acid Agents D018683 - D27.505.696.577.190
└─└─

Agents GABA

GABA Agents D018682 - D27.505.696.577.240
└─└─

Agents glycinergiques

Glycine Agents D018684 - D27.505.696.577.300
└─└─

Agents histaminiques

Histamine Agents D018494 - D27.505.696.577.375
└─└─

Antagonistes du récepteur de la neurokinine-1

Neurokinin-1 Receptor Antagonists D064729 - D27.505.696.577.487
└─└─

Neurostéroïdes

Neurosteroids D000081227 - D27.505.696.577.544
└─└─

Inhibiteurs de la capture des neurotransmetteurs

Neurotransmitter Uptake Inhibitors D014179 - D27.505.696.577.600
└─└─

Agents purinergiques

Purinergic Agents D058905 - D27.505.696.577.725
└─└─

Agents sérotoninergiques

Serotonin Agents D018490 - D27.505.696.577.850
└─└─

Agents du système nerveux autonome

Autonomic Agents D001337 - D27.505.696.663.050
└─└─

Agents neuromusculaires

Neuromuscular Agents D009465 - D27.505.696.663.700
└─└─

Agents du système nerveux sensoriel

Sensory System Agents D018689 - D27.505.696.663.850
└─└─└─

Agents angiogéniques

Angiogenesis Inducing Agents D043925 - D27.505.696.377.077.077
└─└─└─

Antagonistes des androgènes

Androgen Antagonists D000726 - D27.505.696.399.450.065
└─└─└─

Antithyroïdiens

Antithyroid Agents D013956 - D27.505.696.399.450.100
└─└─└─

Calcimimétiques

Calcimimetic Agents D057966 - D27.505.696.399.450.230
└─└─└─

Antagonistes des oestrogènes

Estrogen Antagonists D004965 - D27.505.696.399.450.327
└─└─└─

Modulateurs des récepteurs des oestrogènes

Estrogen Receptor Modulators D020847 - D27.505.696.399.450.360
└─└─└─

Antagonistes de l'insuline

Insulin Antagonists D007329 - D27.505.696.399.450.420
└─└─└─

Antagonistes des leucotriènes

Leukotriene Antagonists D020024 - D27.505.696.399.450.565
└─└─└─

Antagonistes des prostaglandines

Prostaglandin Antagonists D011448 - D27.505.696.399.450.710
└─└─└─

Inhibiteurs de la synthèse des stéroïdes

Steroid Synthesis Inhibitors D065088 - D27.505.696.399.450.855
└─└─└─

Anabolisants

Anabolic Agents D045930 - D27.505.696.399.472.080
└─└─└─

Androgènes

Androgens D000728 - D27.505.696.399.472.161
└─└─└─

Modulateurs des récepteurs de cannabinoïdes

Cannabinoid Receptor Modulators D063385 - D27.505.696.399.472.188
└─└─└─

Oestrogènes

Estrogens D004967 - D27.505.696.399.472.277
└─└─└─

Glucocorticoïdes

Glucocorticoids D005938 - D27.505.696.399.472.488
└─└─└─

Incrétines

Incretins D054795 - D27.505.696.399.472.580
└─└─└─

Minéralocorticoïdes

Mineralocorticoids D008901 - D27.505.696.399.472.673
└─└─└─

Progestines

Progestins D011372 - D27.505.696.399.472.858
└─└─└─

Inhibiteurs du complément

Complement Inactivating Agents D051056 - D27.505.696.477.656.500
└─└─└─

Inhibiteurs des interleukines

Interleukin Inhibitors D000088902 - D27.505.696.477.656.563
└─└─└─

Inhibiteurs de l'interleukine-6

Interleukin-6 Inhibitors D000093242 - D27.505.696.477.656.594
└─└─└─

Modulateurs des récepteurs de la sphingosine 1 phosphate

Sphingosine 1 Phosphate Receptor Modulators D000081243 - D27.505.696.477.656.875
└─└─└─

Complexe vitaminique B

Vitamin B Complex D014803 - D27.505.696.494.600.708
└─└─└─

Diurétiques osmotiques

Diuretics, Osmotic D004234 - D27.505.696.560.500.453
└─└─└─

Diurétiques d'épargne potassique

Diuretics, Potassium Sparing D062865 - D27.505.696.560.500.726
└─└─└─

Inhibiteurs du symport chlorure sodium

Sodium Chloride Symporter Inhibitors D049993 - D27.505.696.560.500.863
└─└─└─

Inhibiteurs du symport chlorure potassium sodium

Sodium Potassium Chloride Symporter Inhibitors D049994 - D27.505.696.560.500.931
└─└─└─

Agonistes adrénergiques

Adrenergic Agonists D000322 - D27.505.696.577.050.100
└─└─└─

Antagonistes adrénergiques

Adrenergic Antagonists D018674 - D27.505.696.577.050.200
└─└─└─

Inhibiteurs de la libération d'acétylcholine

Acetylcholine Release Inhibitors D065087 - D27.505.696.577.120.069
└─└─└─

Agonistes cholinergiques

Cholinergic Agonists D018679 - D27.505.696.577.120.140
└─└─└─

Antagonistes cholinergiques

Cholinergic Antagonists D018680 - D27.505.696.577.120.200
└─└─└─

Anticholinestérasiques

Cholinesterase Inhibitors D002800 - D27.505.696.577.120.300
└─└─└─

Réactivateurs de la cholinestérase

Cholinesterase Reactivators D002801 - D27.505.696.577.120.400
└─└─└─

Agonistes de la dopamine

Dopamine Agonists D018491 - D27.505.696.577.150.151
└─└─└─

Antagonistes de la dopamine

Dopamine Antagonists D018492 - D27.505.696.577.150.175
└─└─└─

Agonistes des acides aminés excitateurs

Excitatory Amino Acid Agonists D018690 - D27.505.696.577.190.200
└─└─└─

Antagonistes des acides aminés excitateurs

Excitatory Amino Acid Antagonists D018691 - D27.505.696.577.190.300
└─└─└─

Agonistes GABA

GABA Agonists D018755 - D27.505.696.577.240.200
└─└─└─

Antagonistes GABA

GABA Antagonists D018756 - D27.505.696.577.240.300
└─└─└─

Modulateurs GABA

GABA Modulators D018757 - D27.505.696.577.240.500
└─└─└─

Agonistes histaminergiques

Histamine Agonists D017442 - D27.505.696.577.375.400
└─└─└─

Antihistaminiques

Histamine Antagonists D006633 - D27.505.696.577.375.425
└─└─└─

Inhibiteurs de la capture adrénergique

Adrenergic Uptake Inhibitors D018759 - D27.505.696.577.600.050
└─└─└─

Inhibiteurs de la capture de la dopamine

Dopamine Uptake Inhibitors D018765 - D27.505.696.577.600.220
└─└─└─

Inhibiteurs de la capture du GABA

GABA Uptake Inhibitors D058805 - D27.505.696.577.600.535
└─└─└─

Inhibiteurs de la recapture de la sérotonine et de la noradrénaline

Serotonin and Noradrenaline Reuptake Inhibitors D000068760 - D27.505.696.577.600.693
└─└─└─

Agonistes purinergiques

Purinergic Agonists D058913 - D27.505.696.577.725.200
└─└─└─

Antagonistes purinergiques

Purinergic Antagonists D058914 - D27.505.696.577.725.400
└─└─└─

Agonistes des récepteurs de la sérotonine

Serotonin Receptor Agonists D017366 - D27.505.696.577.850.800
└─└─└─

Antisérotonines

Serotonin Antagonists D012702 - D27.505.696.577.850.850
└─└─└─

Inhibiteurs sélectifs de la recapture de la sérotonine

Selective Serotonin Reuptake Inhibitors D017367 - D27.505.696.577.850.900
└─└─└─

Ganglioplégiques

Ganglionic Blockers D005730 - D27.505.696.663.050.340
└─└─└─

Gangliostimulants

Ganglionic Stimulants D005731 - D27.505.696.663.050.400
└─└─└─

Myotiques

Miotics D008916 - D27.505.696.663.050.495
└─└─└─

Mydriatiques

Mydriatics D009184 - D27.505.696.663.050.500
└─└─└─

Parasympatholytiques

Parasympatholytics D010276 - D27.505.696.663.050.650
└─└─└─

Parasympathomimétiques

Parasympathomimetics D010277 - D27.505.696.663.050.675
└─└─└─

Sympatholytiques

Sympatholytics D013565 - D27.505.696.663.050.850
└─└─└─

Sympathomimétiques

Sympathomimetics D013566 - D27.505.696.663.050.870
└─└─└─

Curarisants

Neuromuscular Blocking Agents D009466 - D27.505.696.663.700.710
└─└─└─└─

Antagonistes du récepteur des androgènes

Androgen Receptor Antagonists D059002 - D27.505.696.399.450.065.249
└─└─└─└─

Antiandrogènes non stéroïdiens

Nonsteroidal Anti-Androgens D057466 - D27.505.696.399.450.065.500
└─└─└─└─

Antagonistes des récepteurs des oestrogènes

Estrogen Receptor Antagonists D065171 - D27.505.696.399.450.327.650
└─└─└─└─

Modulateurs sélectifs des récepteurs des oestrogènes

Selective Estrogen Receptor Modulators D020845 - D27.505.696.399.450.360.827
└─└─└─└─

Inhibiteurs de la 14-alpha déméthylase

14-alpha Demethylase Inhibitors D058888 - D27.505.696.399.450.855.100
└─└─└─└─

Inhibiteurs de la 5-alpha réductase

5-alpha Reductase Inhibitors D058891 - D27.505.696.399.450.855.200
└─└─└─└─

Inhibiteurs de l'aromatase

Aromatase Inhibitors D047072 - D27.505.696.399.450.855.300
└─└─└─└─

Agonistes des récepteurs de cannabinoïdes

Cannabinoid Receptor Agonists D063386 - D27.505.696.399.472.188.500
└─└─└─└─

Antagonistes des récepteurs de cannabinoïdes

Cannabinoid Receptor Antagonists D063387 - D27.505.696.399.472.188.750
└─└─└─└─

Oestrogènes nonstéroïdiens

Estrogens, Non-Steroidal D004968 - D27.505.696.399.472.277.540
└─└─└─└─

Antagonistes du récepteur B2 de la bradykinine

Bradykinin B2 Receptor Antagonists D065094 - D27.505.696.477.656.500.500
└─└─└─└─

Bloqueurs de canaux sodiques épithéliaux

Epithelial Sodium Channel Blockers D062686 - D27.505.696.560.500.726.100
└─└─└─└─

Antagonistes des récepteurs des minéralocorticoïdes

Mineralocorticoid Receptor Antagonists D000451 - D27.505.696.560.500.726.249
└─└─└─└─

Agonistes alpha-adrénergiques

Adrenergic alpha-Agonists D000316 - D27.505.696.577.050.100.100
└─└─└─└─

Agonistes bêta-adrénergiques

Adrenergic beta-Agonists D000318 - D27.505.696.577.050.100.200
└─└─└─└─

Antagonistes alpha-adrénergiques

Adrenergic alpha-Antagonists D000317 - D27.505.696.577.050.200.100
└─└─└─└─

Antagonistes bêta-adrénergiques

Adrenergic beta-Antagonists D000319 - D27.505.696.577.050.200.200
└─└─└─└─

Agonistes muscariniques

Muscarinic Agonists D018721 - D27.505.696.577.120.140.500
└─└─└─└─

Agonistes nicotiniques

Nicotinic Agonists D018722 - D27.505.696.577.120.140.700
└─└─└─└─

Antagonistes muscariniques

Muscarinic Antagonists D018727 - D27.505.696.577.120.200.500
└─└─└─└─

Antagonistes nicotiniques

Nicotinic Antagonists D018733 - D27.505.696.577.120.200.700
└─└─└─└─

Antagonistes du récepteur D2 de la dopamine

Dopamine D2 Receptor Antagonists D065127 - D27.505.696.577.150.175.500
└─└─└─└─

Agonistes du récepteur GABA-A

GABA-A Receptor Agonists D058785 - D27.505.696.577.240.200.500
└─└─└─└─

Agonistes du recepteur GABA-B

GABA-B Receptor Agonists D058786 - D27.505.696.577.240.200.750
└─└─└─└─

Antagonistes du récepteur GABA-A

GABA-A Receptor Antagonists D058787 - D27.505.696.577.240.300.500
└─└─└─└─

Antagonistes du récepteur GABA-B

GABA-B Receptor Antagonists D058788 - D27.505.696.577.240.300.750
└─└─└─└─

Antihistaminiques des récepteurs H1

Histamine H1 Antagonists D006634 - D27.505.696.577.375.425.400
└─└─└─└─

Antihistaminiques des récepteurs H2

Histamine H2 Antagonists D006635 - D27.505.696.577.375.425.425
└─└─└─└─

Antihistaminiques des récepteurs H3

Histamine H3 Antagonists D054828 - D27.505.696.577.375.425.712
└─└─└─└─

Agonistes des récepteurs purinergiques P1

Purinergic P1 Receptor Agonists D058906 - D27.505.696.577.725.200.100
└─└─└─└─

Agonistes des récepteurs purinergiques P2

Purinergic P2 Receptor Agonists D058910 - D27.505.696.577.725.200.200
└─└─└─└─

Antagonistes des récepteurs purinergiques P1

Purinergic P1 Receptor Antagonists D058915 - D27.505.696.577.725.400.100
└─└─└─└─

Antagonistes des récepteurs purinergiques P2

Purinergic P2 Receptor Antagonists D058919 - D27.505.696.577.725.400.200
└─└─└─└─

Agonistes des récepteurs 5-HT1 de la sérotonine

Serotonin 5-HT1 Receptor Agonists D058825 - D27.505.696.577.850.800.100
└─└─└─└─

Agonistes des récepteurs 5-HT2 de la sérotonine

Serotonin 5-HT2 Receptor Agonists D058826 - D27.505.696.577.850.800.200
└─└─└─└─

Agonistes des récepteurs 5-HT3 de la sérotonine

Serotonin 5-HT3 Receptor Agonists D058827 - D27.505.696.577.850.800.300
└─└─└─└─

Agonistes des récepteurs 5-HT4 de la sérotonine

Serotonin 5-HT4 Receptor Agonists D058828 - D27.505.696.577.850.800.400
└─└─└─└─

Antagonistes des récepteurs 5-HT1 de la sérotonine

Serotonin 5-HT1 Receptor Antagonists D058829 - D27.505.696.577.850.850.100
└─└─└─└─

Antagonistes des récepteurs 5-HT2 de la sérotonine

Serotonin 5-HT2 Receptor Antagonists D058830 - D27.505.696.577.850.850.200
└─└─└─└─

Antagonistes des récepteurs 5-HT3 de la sérotonine

Serotonin 5-HT3 Receptor Antagonists D058831 - D27.505.696.577.850.850.300
└─└─└─└─

Antagonistes des récepteurs 5-HT4 de la sérotonine

Serotonin 5-HT4 Receptor Antagonists D058832 - D27.505.696.577.850.850.400
└─└─└─└─

Curarisants dépolarisants

Neuromuscular Depolarizing Agents D009467 - D27.505.696.663.700.710.550
└─└─└─└─

Curarisants non dépolarisants

Neuromuscular Nondepolarizing Agents D003473 - D27.505.696.663.700.710.575
└─└─└─└─└─

Phyto-oestrogènes

Phytoestrogens D048789 - D27.505.696.399.472.277.540.500
└─└─└─└─└─

Agonistes des récepteurs alpha-1 adrénergiques

Adrenergic alpha-1 Receptor Agonists D058646 - D27.505.696.577.050.100.100.100
└─└─└─└─└─

Agonistes des récepteurs alpha-2 adrénergiques

Adrenergic alpha-2 Receptor Agonists D058647 - D27.505.696.577.050.100.100.200
└─└─└─└─└─

Agonistes des récepteurs bêta-1 adrénergiques

Adrenergic beta-1 Receptor Agonists D058665 - D27.505.696.577.050.100.200.100
└─└─└─└─└─

Agonistes des récepteurs béta-2 adrénergiques

Adrenergic beta-2 Receptor Agonists D058666 - D27.505.696.577.050.100.200.200
└─└─└─└─└─

Agonistes des récepteurs bêta-3 adrénergiques

Adrenergic beta-3 Receptor Agonists D058667 - D27.505.696.577.050.100.200.300
└─└─└─└─└─

Antagonistes des récepteurs alpha-1 adrénergiques

Adrenergic alpha-1 Receptor Antagonists D058668 - D27.505.696.577.050.200.100.100
└─└─└─└─└─

Antagonistes des récepteurs alpha-2 adrénergiques

Adrenergic alpha-2 Receptor Antagonists D058669 - D27.505.696.577.050.200.100.200
└─└─└─└─└─

Antagonistes des récepteurs bêta-1 adrénergiques

Adrenergic beta-1 Receptor Antagonists D058671 - D27.505.696.577.050.200.200.100
└─└─└─└─└─

Antagonistes des récepteurs bêta-2 adrénergiques

Adrenergic beta-2 Receptor Antagonists D058672 - D27.505.696.577.050.200.200.200
└─└─└─└─└─

Antagonistes des récepteurs bêta-3 adrénergiques

Adrenergic beta-3 Receptor Antagonists D058673 - D27.505.696.577.050.200.200.300
└─└─└─└─└─

Antihistaminiques H1 non sédatifs

Histamine H1 Antagonists, Non-Sedating D039563 - D27.505.696.577.375.425.400.500
└─└─└─└─└─

Agonistes du récepteur A1 à l'adénosine

Adenosine A1 Receptor Agonists D058907 - D27.505.696.577.725.200.100.100
└─└─└─└─└─

Agonistes des récepteurs A2 à l'adénosine

Adenosine A2 Receptor Agonists D058908 - D27.505.696.577.725.200.100.200
└─└─└─└─└─

Agonistes du récepteur A3 à l'adénosine

Adenosine A3 Receptor Agonists D058909 - D27.505.696.577.725.200.100.300
└─└─└─└─└─

Agonistes des récepteurs purinergiques P2X

Purinergic P2X Receptor Agonists D058911 - D27.505.696.577.725.200.200.100
└─└─└─└─└─

Agonistes des récepteurs purinergiques P2Y

Purinergic P2Y Receptor Agonists D058912 - D27.505.696.577.725.200.200.200
└─└─└─└─└─

Antagonistes du récepteur A1 à l'adénosine

Adenosine A1 Receptor Antagonists D058916 - D27.505.696.577.725.400.100.100
└─└─└─└─└─

Antagonistes des récepteurs A2 à l'adénosine

Adenosine A2 Receptor Antagonists D058917 - D27.505.696.577.725.400.100.200
└─└─└─└─└─

Antagonistes du récepteur A3 à l'adénosine

Adenosine A3 Receptor Antagonists D058918 - D27.505.696.577.725.400.100.300
└─└─└─└─└─

Antagonistes des récepteurs purinergiques P2X

Purinergic P2X Receptor Antagonists D058920 - D27.505.696.577.725.400.200.100
└─└─└─└─└─

Antagonistes des récepteurs purinergiques P2Y

Purinergic P2Y Receptor Antagonists D058921 - D27.505.696.577.725.400.200.200

Auteurs principaux

Thorsten Lehr

7 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
Publications dans "Effets physiologiques des médicaments" : Voir toutes les publications (7)

Dominik Selzer

6 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
Publications dans "Effets physiologiques des médicaments" : Voir toutes les publications (6)

Matthias Schwab

5 publications dans cette catégorie

Affiliations :
  • Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.
  • Cluster of Excellence iFIT (EXC2180) "Image-guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany.
Publications dans "Effets physiologiques des médicaments" :

Fatima Zahra Marok

4 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, 66123 Saarbruecken, Germany.
Publications dans "Effets physiologiques des médicaments" :

Laura Maria Fuhr

4 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, 66123 Saarbruecken, Germany.
Publications dans "Effets physiologiques des médicaments" :

Helena Leonie Hanae Loer

3 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
Publications dans "Effets physiologiques des médicaments" :

Simeon Rüdesheim

3 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
  • Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Publications dans "Effets physiologiques des médicaments" :

Atsushi Kambayashi

2 publications dans cette catégorie

Affiliations :
  • Pharmaceutical Research and Technology Labs, Astellas Pharma Inc., 180 Ozumi, Yaizu, Shizuoka, 425-0072, Japan; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Publications dans "Effets physiologiques des médicaments" :

Yukio Otsuka

2 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacology and Exploratory Development, Astellas Pharma Inc., Tokyo, Japan.
Publications dans "Effets physiologiques des médicaments" :

Mary P Choules

2 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Inc., Northbrook, Illinois, USA.
Publications dans "Effets physiologiques des médicaments" :

Kunal S Taskar

2 publications dans cette catégorie

Affiliations :
  • DMPK, IVIVT, GlaxoSmithKline R&D, Stevenage, United Kingdom.
Publications dans "Effets physiologiques des médicaments" :

Sebastian Frechen

2 publications dans cette catégorie

Affiliations :
  • Bayer AG, Pharmaceuticals, Research & Development, Systems Pharmacology & Medicine, Leverkusen, Germany.
Publications dans "Effets physiologiques des médicaments" :

Felix Stader

2 publications dans cette catégorie

Affiliations :
  • Certara UK Limited, Sheffield, UK.
Publications dans "Effets physiologiques des médicaments" :

Manuel Battegay

2 publications dans cette catégorie

Affiliations :
  • Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
  • University of Basel, Basel, Switzerland.
Publications dans "Effets physiologiques des médicaments" :

Catia Marzolini

2 publications dans cette catégorie

Affiliations :
  • Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
  • University of Basel, Basel, Switzerland.
  • University of Liverpool, Liverpool, UK.
Publications dans "Effets physiologiques des médicaments" :

Jan-Georg Wojtyniak

2 publications dans cette catégorie

Affiliations :
  • Clinical Pharmacy, Saarland University, 66123 Saarbruecken, Germany.
  • Dr. Margarete Fischer-Bosch-Institut of Clinical Pharmacology, 70376 Stuttgart, Germany.
Publications dans "Effets physiologiques des médicaments" :

Bhagwat Prasad

2 publications dans cette catégorie

Affiliations :
  • Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, USA. Electronic address: bhagwat.prasad@wsu.edu.
Publications dans "Effets physiologiques des médicaments" :

Nina Hanke

2 publications dans cette catégorie

Affiliations :
  • Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach, Germany. nina.hanke@boehringer-ingelheim.com.
Publications dans "Effets physiologiques des médicaments" :

Peter Stopfer

2 publications dans cette catégorie

Affiliations :
  • Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach, Germany.
Publications dans "Effets physiologiques des médicaments" :

Valerie Nock

2 publications dans cette catégorie

Affiliations :
  • Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach, Germany.
Publications dans "Effets physiologiques des médicaments" :

Sources (10000 au total)

A drug-drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5-lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam.

03 Jun 2024
DOI: 10.1111/bcp.16131 PMID: 38830622

Early clinical studies have indicated that the pharmacokinetics of Atuliflapon (AZD5718) are time and dose dependent. The reason(s) for these findings is(are) not fully understood, but pre-clinical pr... Open-label, fixed-sequence study in healthy volunteers to assess the PK of midazolam alone and in combination with Atuliflapon. Fourteen healthy male subjects received single oral dose of midazolam 2 ... Mean midazolam values of maximum plasma concentration (C... Atuliflapon is a weak inhibitor of CYP3A4; this was confirmed by the validated PBPK model. This weak inhibition is predicted to have a minor PK effect on CYP3A4 metabolized drugs....

Modeling the Complexity of Drug-Drug Interactions: A Physiologically-based Pharmacokinetic Study of Lenvatinib with Schisantherin A/Schisandrin A.

29 Mar 2024
DOI: 10.1016/j.ejps.2024.106757 PMID: 38556066

Lenvatinib's efficacy as a frontline targeted therapy for radioactive iodine-refractory thyroid carcinoma and advanced hepatocellular carcinoma owes to its inhibition of multiple tyrosine kinases. How... To explore potential DDIs between lenvatinib and STA/SIA, we developed a physiologically-based pharmacokinetic (PBPK) model for lenvatinib and used it to construct a DDI model for lenvatinib and STA/S... Following single-dose administration, the predicted area under the plasma concentration-time curve (AUC) and maximum plasma concentrations (C... Our study developed the first PBPK and DDI models for lenvatinib as a victim drug. STA and SIA slightly increased lenvatinib exposure in simulations, providing clinically valuable information on the s...

Physiologically based pharmacokinetic modelling to predict potential drug-drug interactions of dersimelagon (MT-7117).

04 Oct 2024
DOI: 10.1111/bcp.16271 PMID: 39367654

Dersimelagon is a novel, investigational, orally administered, selective agonist of the melanocortin-1 receptor that has demonstrated efficacy at increasing symptom-free light exposure and an acceptab... The data from in silico, in vitro and in vivo studies were used to construct a PBPK model for dersimelagon to assess the DDI potential between dersimelagon and substrate drugs for cytochrome P450 3A, ... The systemic exposure of atorvastatin based on the maximum plasma concentration and area under the plasma concentration-time curve was predicted to increase 1.21-fold and 1.25-fold, respectively, if c... Overall, PBPK modelling results indicate that the simulated changes in plasma exposure of atorvastatin and rosuvastatin following coadministration with dersimelagon 100 or 200 mg are not clinically si...