Prevalence of hepatitis C virus infection and the IL28B genotype polymorphism among blood donors and high-risk populations.
HCV genotype
IL28B
Singapore
hepatitis C
prevalence
Journal
Singapore medical journal
ISSN: 2737-5935
Titre abrégé: Singapore Med J
Pays: India
ID NLM: 0404516
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
22
6
2018
medline:
26
7
2019
entrez:
22
6
2018
Statut:
ppublish
Résumé
To study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive. The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least six months of follow-up between January 2009 and December 2014. IVDU population was from inmates at halfway houses who consented. Between 2011 and 2014, of 161,658 individuals who underwent screening prior to blood donation, 95 (0.059%) were positive for HCV. Of the 42 sera available, common genotypes (GTs) were GT-3 (47.6%) and GT-1 (31.0%). Of 1,575 HD patients, 2.2% were anti-HCV positive. The HCV GT distribution was HCV GT-1 (32.4%), HCV GT-3 (20.5%) and GT-6 (8.8%). 83 halfway house inmates were screened. Of the 47 IVDUs, 36.2% were anti-HCV positive with predominant GT-3 (%). IL28B polymorphism was noted to be CC predominantly 85.3%. Prevalence of HCV infection has decreased in both the BD and HD populations. However, it remains high in the IVDU population. GT-1 remains the most common in the HD population; however, GT-3 infection is now more common among the BD population in Singapore. IL28B - CC is the predominant variant among the HCV-infected individuals in Singapore.
Identifiants
pubmed: 29926111
pii: j60/1/34
doi: 10.11622/smedj.2018078
pmc: PMC6351688
doi:
Substances chimiques
interferon-lambda, human
0
Interleukins
0
Interferons
9008-11-1
Types de publication
Journal Article
Langues
eng
Pagination
34-39Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright: © Singapore Medical Association.
Références
Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:127-9
pubmed: 7533946
Nature. 2009 Sep 17;461(7262):399-401
pubmed: 19684573
Singapore Med J. 2007 Jun;48(6):504-8
pubmed: 17538746
Semin Dial. 2007 Sep-Oct;20(5):416-22
pubmed: 17897248
Kidney Int Suppl. 2008 Apr;(109):S1-99
pubmed: 18382440
Nature. 2009 Oct 8;461(7265):798-801
pubmed: 19759533
Int J Med Sci. 2006;3(2):41-6
pubmed: 16614741
World J Gastroenterol. 2008 Jun 7;14(21):3416-20
pubmed: 18528940
Infect Genet Evol. 2005 Mar;5(2):131-9
pubmed: 15639745
Int J Drug Policy. 2007 Oct;18(5):352-8
pubmed: 17854722
Sci Rep. 2015 Nov 30;5:17410
pubmed: 26616669
Korean J Intern Med. 2015 Jul;30(4):423-33
pubmed: 26161008
Kidney Int. 1997 Apr;51(4):981-99
pubmed: 9083262
Gastroenterology. 2002 May;122(6):1554-68
pubmed: 12016423
Gastroenterol Rep (Oxf). 2017 Aug;5(3):208-212
pubmed: 28852525
J Public Health Med. 1995 Dec;17(4):387-91
pubmed: 8639336
Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):553-62
pubmed: 23817321
Lancet. 2016 Sep 10;388(10049):1081-1088
pubmed: 27394647
Hepatology. 2015 Jan;61(1):77-87
pubmed: 25069599
Hepatology. 2013 Apr;57(4):1333-42
pubmed: 23172780