Protein hydrolysates and ultrafiltered < 1 KDa fractions from Phaseolus lunatus, Phaseolus vulgaris and Mucuna pruriens exhibit antihyperglycemic activity, intestinal glucose absorption and α-glucosidase inhibition with no acute toxicity in rodents.
Animals
Glucose
/ metabolism
Glycoside Hydrolase Inhibitors
/ administration & dosage
Humans
Hyperglycemia
/ drug therapy
Hypoglycemic Agents
/ administration & dosage
Intestinal Absorption
/ drug effects
Intestinal Mucosa
/ drug effects
Male
Mice
Mice, Inbred ICR
Mucuna
/ chemistry
Phaseolus
/ chemistry
Protein Hydrolysates
/ administration & dosage
Rats
Rats, Wistar
Ultrafiltration
alpha-Glucosidases
/ metabolism
Mucuna pruriens
Phaseolus lunatus
Phaseolus vulgaris
antihyperglycemic activity
protein hydrolysates
Journal
Journal of the science of food and agriculture
ISSN: 1097-0010
Titre abrégé: J Sci Food Agric
Pays: England
ID NLM: 0376334
Informations de publication
Date de publication:
30 Jan 2019
30 Jan 2019
Historique:
received:
21
02
2018
revised:
19
06
2018
accepted:
20
06
2018
pubmed:
26
6
2018
medline:
12
1
2019
entrez:
26
6
2018
Statut:
ppublish
Résumé
Protein hydrolysates from food plants, such as legumes, have emerged as a new alternative to treat hyperglycemia, an important risk factor contributing to the development of type 2 diabetes mellitus (T2DM) and its complications. The aim of this work was to assess the antihyperglycemic activity and inhibition of α-glucosidase, and intestinal glucose absorption, and acute toxicity of total hydrolysates and < 1 kDa fractions from Phaseolus lunatus L., Phaseolus vulgaris L., and Mucuna pruriens (L.) DC., obtained by hydrolysis with Alcalase®-Flavourzyme® or pepsine-pancreatin enzymatic systems. In vivo results showed that three of six total hydrolysates and four of six < 1 kDa fractions suppressed starch-induced postprandial hyperglycemia (ED These results suggest that hydrolysates and < 1 kDa fractions from P. lunatus, P. vulgaris and M. pruriens are suitable candidates to treat or prevent T2DM. © 2018 Society of Chemical Industry.
Sections du résumé
BACKGROUND
BACKGROUND
Protein hydrolysates from food plants, such as legumes, have emerged as a new alternative to treat hyperglycemia, an important risk factor contributing to the development of type 2 diabetes mellitus (T2DM) and its complications. The aim of this work was to assess the antihyperglycemic activity and inhibition of α-glucosidase, and intestinal glucose absorption, and acute toxicity of total hydrolysates and < 1 kDa fractions from Phaseolus lunatus L., Phaseolus vulgaris L., and Mucuna pruriens (L.) DC., obtained by hydrolysis with Alcalase®-Flavourzyme® or pepsine-pancreatin enzymatic systems.
RESULTS
RESULTS
In vivo results showed that three of six total hydrolysates and four of six < 1 kDa fractions suppressed starch-induced postprandial hyperglycemia (ED
CONCLUSION
CONCLUSIONS
These results suggest that hydrolysates and < 1 kDa fractions from P. lunatus, P. vulgaris and M. pruriens are suitable candidates to treat or prevent T2DM. © 2018 Society of Chemical Industry.
Substances chimiques
Glycoside Hydrolase Inhibitors
0
Hypoglycemic Agents
0
Protein Hydrolysates
0
alpha-Glucosidases
EC 3.2.1.20
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
587-595Subventions
Organisme : 'Red de Farmoquímicos'
ID : CONACyT/280002
Organisme : 'Red de Metabolómica de plantas'
ID : PRODEP-SEP
Informations de copyright
© 2018 Society of Chemical Industry.