Prognostic Indicators in Stage IV Surgically Treated Gastric Cancer Patients: A Retrospective Multi-Institutional Study.


Journal

Digestive surgery
ISSN: 1421-9883
Titre abrégé: Dig Surg
Pays: Switzerland
ID NLM: 8501808

Informations de publication

Date de publication:
2019
Historique:
received: 20 08 2017
accepted: 26 03 2018
pubmed: 27 6 2018
medline: 3 1 2020
entrez: 27 6 2018
Statut: ppublish

Résumé

The role of gastric resection in treating metastatic gastric adenocarcinoma is controversial. In the present study, we reviewed the short- and long-term outcomes of stage IV patients undergoing surgery. A retrospective review was conducted that assessed patients undergoing elective surgery for incurable gastric carcinoma. Short- and long-term results were evaluated. A total of 122 stage IV gastric cancer patients were assessed. Postoperative mortality was 5.7%, and the overall rate of complications was 35.2%. The overall survival rate at 1 and 3 years was 58 and 19% respectively; the median survival was 14 months. Improved survival was observed for the factors age less than 60 years (p = 0.015), site of metastases (p = 0.022), extended lymph node dissection (p = 0.044), absence of residual disease after surgery (p = 0.001), and administration of adjuvant chemotherapy (p = 0.016). Multivariate analysis showed that residual disease and adjuvant chemotherapy were independent prognostic factors. The results of this study suggest that surgery combined with systemic chemotherapy in selected patients with stage IV gastric cancer can improve survival.

Identifiants

pubmed: 29945145
pii: 000488775
doi: 10.1159/000488775
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

331-339

Informations de copyright

© 2018 S. Karger AG, Basel.

Auteurs

Alberto Biondi (A)

Polo Scienze Gastroenterologiche ed Endocrino-Metaboliche, Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli Largo F. Vito, Rome, Italy, alberto.biondi@policlinicogemelli.it.

Domenico D'Ugo (D)

Polo Scienze Gastroenterologiche ed Endocrino-Metaboliche, Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli Largo F. Vito, Rome, Italy.

Ferdinando Cananzi (F)

Surgical Oncology Unit - Humanitas Clinical and Research Center, Rozzano, Italy.

Stefano Rausei (S)

Department of Surgery, University of Insubria, Viale Luigi Borri, Varese, Italy.

Federico Sicoli (F)

Surgical Oncology Unit - Humanitas Clinical and Research Center, Rozzano, Italy.

Francesco Santullo (F)

Polo Scienze Gastroenterologiche ed Endocrino-Metaboliche, Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli Largo F. Vito, Rome, Italy.

Antonio Laurino (A)

Polo Scienze Gastroenterologiche ed Endocrino-Metaboliche, Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli Largo F. Vito, Rome, Italy.

Laura Ruspi (L)

Department of Surgery, University of Insubria, Viale Luigi Borri, Varese, Italy.

Francesco Belia (F)

Polo Scienze Gastroenterologiche ed Endocrino-Metaboliche, Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli Largo F. Vito, Rome, Italy.

Vittorio Quagliuolo (V)

Surgical Oncology Unit - Humanitas Clinical and Research Center, Rozzano, Italy.

Roberto Persiani (R)

Polo Scienze Gastroenterologiche ed Endocrino-Metaboliche, Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli Largo F. Vito, Rome, Italy.

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Classifications MeSH