Frailty modifications and prognostic impact in older patients admitted in acute care.
Elderly
Frailty
Hospitalization
Length of stay
Mortality
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
22
02
2018
accepted:
11
06
2018
pubmed:
28
6
2018
medline:
14
3
2019
entrez:
28
6
2018
Statut:
ppublish
Résumé
Frailty is a predictor of adverse outcomes in older subjects. The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes. Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge. A statistically significant difference was reported between the aFI (0.31, IQR 0.19-0.44) and the dFI (0.29, IQR 0.19-0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0-17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4-12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2-17.9, p = 0.03). Frailty is a strong predictor of negative endpoints in hospitalized older persons. Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
Sections du résumé
BACKGROUND
BACKGROUND
Frailty is a predictor of adverse outcomes in older subjects.
AIMS
OBJECTIVE
The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes.
METHODS
METHODS
Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge.
RESULTS
RESULTS
A statistically significant difference was reported between the aFI (0.31, IQR 0.19-0.44) and the dFI (0.29, IQR 0.19-0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0-17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4-12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2-17.9, p = 0.03).
CONCLUSION
CONCLUSIONS
Frailty is a strong predictor of negative endpoints in hospitalized older persons.
DISCUSSION
CONCLUSIONS
Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
Identifiants
pubmed: 29946755
doi: 10.1007/s40520-018-0989-7
pii: 10.1007/s40520-018-0989-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM