Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study.
Allografts
Animals
Cell Proliferation
Female
Graft Survival
Heart Transplantation
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Inflammation
Lymphocytes
/ cytology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myeloid Cells
/ cytology
Myocytes, Cardiac
/ drug effects
Phenotype
RNA, Messenger
/ metabolism
Reperfusion Injury
T-Lymphocytes
/ cytology
Transplantation, Homologous
Vascular Endothelial Growth Factor A
/ metabolism
differentiation
immune regulation
innate immunity
macrophage
maturation
monocyte biology
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
27
02
2018
revised:
03
04
2018
accepted:
19
06
2018
pubmed:
29
6
2018
medline:
6
2
2019
entrez:
29
6
2018
Statut:
ppublish
Résumé
Hypoxia-inducible factors (HIFs) play a critical role in inflammatory properties of myeloid-derived cells. The effect of HIFs on myeloid-derived cell functions in organ transplantation remains unknown, however. We transplanted hearts into transgenic mice with myeloid cell-targeted deletions of HIF-1α or its negative regulator von Hippel-Lindau (VHL) to investigate the effects of HIF-1α inactivation or HIF pathway activation, respectively, on ischemia-reperfusion injury (IRI) and acute rejection. Deletion of VHL in myeloid cells enhanced mRNA expression of anti-inflammatory genes IDO, Arg-1, and HO-1 in vitro. In vivo, VHL
Substances chimiques
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
RNA, Messenger
0
Vascular Endothelial Growth Factor A
0
vascular endothelial growth factor A, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-106Subventions
Organisme : Roche Organ Transplantation Research Foundation
Pays : International
Organisme : Academy of Finland
Pays : International
Organisme : Helsinki University Central Hospital Research Funds
Pays : International
Organisme : Sigrid Juselius Foundation
Pays : International
Organisme : Finnish Cultural Foundation
Pays : International
Organisme : Finnish Foundation of Cardiovascular Research
Pays : International
Organisme : Päivikki and Sakari Sohlberg Foundation
Pays : International
Organisme : Aarne Koskelo Foundation
Pays : International
Organisme : Research Foundation of the University of Helsinki
Pays : International
Organisme : Aarne and Aili Turunen Foundation
Pays : International
Organisme : Finska Läkaresällskapet
Pays : International
Organisme : Research and Science Foundation of Farmos
Pays : International
Organisme : Finnish Medical Foundation
Pays : International
Organisme : Biomedicum Foundation
Pays : International
Organisme : Paavo Nurmi Foundation
Pays : International
Organisme : Emil Aaltonen Foundation
Pays : International
Organisme : Karoliina and Kustaa Lindeman Foundation
Pays : International
Informations de copyright
© 2018 Steunstichting ESOT.