Insights from intoxicated Drosophila.

Alcoholism / genetics Animals Drosophila melanogaster / drug effects Genome-Wide Association Study
Addiction Alcohol Behavior Brain Circuits Drosophila Genetics Model organism Neuroimmune

Journal

Alcohol (Fayetteville, N.Y.)
ISSN: 1873-6823
Titre abrégé: Alcohol
Pays: United States
ID NLM: 8502311

Informations de publication

Date de publication:
02 2019
Historique:
received: 19 02 2018
revised: 14 03 2018
accepted: 14 03 2018
pubmed: 8 7 2018
medline: 31 3 2020
entrez: 8 7 2018
Statut: ppublish

Résumé

Our understanding of alcohol use disorder (AUD), particularly alcohol's effects on the nervous system, has unquestionably benefited from the use of model systems such as Drosophila melanogaster. Here, we briefly introduce the use of flies in alcohol research, and highlight the genetic accessibility and neurobiological contribution that flies have made to our understanding of AUD. Future fly research offers unique opportunities for addressing unresolved questions in the alcohol field, such as the neuromolecular and circuit basis for cravings and alcohol-induced neuroimmune dysfunction. This review strongly advocates for interdisciplinary approaches and translational collaborations with the united goal of confronting the major health problems associated with alcohol abuse and addiction.

Identifiants

DOI: 10.1016/j.alcohol.2018.03.004 PMID: 29980341 PMC: PMC6150843
pubmed: 29980341
pii: S0741-8329(18)30040-5
doi: 10.1016/j.alcohol.2018.03.004
pmc: PMC6150843
mid: NIHMS953230
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

21-27

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103645
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024434
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Emily Petruccelli (E)

Neuroscience Department, Brown University, Providence, RI 02912, United States.

Karla R Kaun (KR)

Neuroscience Department, Brown University, Providence, RI 02912, United States. Electronic address: karla_kaun@brown.edu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Alcoolisme › Insights from intoxicated Drosophila.
questionsmedicales.fr › Eucaryotes › Animaux › Insights from intoxicated Drosophila.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Insights from intoxicated Drosophila.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Insights from intoxicated Drosophila.