Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
4-Aminobutyrate Transaminase
/ genetics
Animals
Brain Neoplasms
/ genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glioma
/ genetics
Glutamate Dehydrogenase
/ genetics
Glutamic Acid
/ metabolism
Glutaminase
/ genetics
Humans
Isocitrate Dehydrogenase
/ genetics
Lactic Acid
/ metabolism
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
Neoplasm Invasiveness
Stress, Physiological
Succinate-Semialdehyde Dehydrogenase
/ genetics
Transcriptome
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
anaplerosis
diffuse infiltration
glycolysis
metabolism
neurotransmitters
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
13
7
2018
medline:
10
7
2019
entrez:
13
7
2018
Statut:
ppublish
Résumé
Diffuse gliomas often carry point mutations in isocitrate dehydrogenase ( IDH1
Identifiants
pubmed: 30001166
doi: 10.1096/fj.201800907RR
doi:
Substances chimiques
Lactic Acid
33X04XA5AT
Glutamic Acid
3KX376GY7L
Isocitrate Dehydrogenase
EC 1.1.1.41
IDH1 protein, human
EC 1.1.1.42.
ALDH5A1 protein, human
EC 1.2.1.24
Succinate-Semialdehyde Dehydrogenase
EC 1.2.1.24
Glutamate Dehydrogenase
EC 1.4.1.2
GLUD1 protein, human
EC 1.4.1.3
4-Aminobutyrate Transaminase
EC 2.6.1.19
GLS protein, human
EC 3.5.1.2
Glutaminase
EC 3.5.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM