A dietary pattern derived using B-vitamins and its relationship with vascular markers over the life course.

Adult Carotid Intima-Media Thickness / statistics & numerical data Cohort Studies Diet / methods Female Folic Acid / administration & dosage Homocysteine / blood Humans Longitudinal Studies Male Middle Aged Pulse Wave Analysis / methods United Kingdom Vitamin B 12 / administration & dosage Vitamin B Complex / administration & dosage

Dietary patterns Folate Homocysteine Intima-media thickness Pulse wave velocity Reduced rank regression

Journal

Clinical nutrition (Edinburgh, Scotland)

ISSN: 1532-1983

Titre abrégé: Clin Nutr

Pays: England

ID NLM: 8309603

Informations de publication

Date de publication:
06 2019

Historique:

received: 24 08 2017

revised: 20 03 2018

accepted: 18 06 2018

pubmed: 15 7 2018

medline: 2 6 2020

entrez: 15 7 2018

Statut: ppublish

Résumé

Diet may influence vascular function through elevated homocysteine (Hcy) concentrations. However the relationship between dietary patterns (DP), characterised by Hcy and its associated nutrients is unknown. To identify a DP characterised by plasma Hcy, dietary folate and dietary vitamin B12, and examine its associations with two markers of vascular function: carotid intima-media thickness (cIMT) and pulse wave velocity (PWV). 1562 participants of the MRC National Survey of Health and Development (NSHD), a British birth cohort, with dietary data measured at least once between 36 and 60-64 years, and cIMT or PWV measured at 60-64 years were included. DPs were derived using reduced rank regression with three intermediate variables: 1) plasma Hcy (μmol/L) 2) folate intake (μg/1000 kcal) 3) vitamin B12 intake (μg/1000 kcal). Multiple regression models assessed associations between the derived DP z-scores and vascular function adjusting for dietary misreporting, socioeconomic position, BMI, smoking, physical activity and diabetes. A DP explaining the highest amount of shared variation (4.5%) in plasma Hcy, dietary folate and dietary vitamin B12 highly correlated with folate (r = 0.96), moderately correlated with vitamin B12 (r = 0.27), and weakly correlated with Hcy (r = 0.10). This "high B-vitamin" DP (including folate) was characterised by high intakes of vegetables, fruit and low fibre breakfast cereal, and low intakes of processed meat, white bread, sugar and preserves. No associations were observed between DP z-scores and vascular function at any time point following adjustment for covariates. This study explored a specific hypothesised pathway linking diet to vascular function. Although we found no consistent evidence for an association between a high B-vitamin DP and vascular function, we did observe an association with CRP and triglycerides in secondary analyses. Further analyses using strongly correlated and biologically relevant intermediate variables are required to refine investigations into diet and CVD in longitudinal cohort data.

Sections du résumé

BACKGROUND

OBJECTIVE

To identify a DP characterised by plasma Hcy, dietary folate and dietary vitamin B12, and examine its associations with two markers of vascular function: carotid intima-media thickness (cIMT) and pulse wave velocity (PWV).

METHODS

1562 participants of the MRC National Survey of Health and Development (NSHD), a British birth cohort, with dietary data measured at least once between 36 and 60-64 years, and cIMT or PWV measured at 60-64 years were included. DPs were derived using reduced rank regression with three intermediate variables: 1) plasma Hcy (μmol/L) 2) folate intake (μg/1000 kcal) 3) vitamin B12 intake (μg/1000 kcal). Multiple regression models assessed associations between the derived DP z-scores and vascular function adjusting for dietary misreporting, socioeconomic position, BMI, smoking, physical activity and diabetes.

RESULTS

A DP explaining the highest amount of shared variation (4.5%) in plasma Hcy, dietary folate and dietary vitamin B12 highly correlated with folate (r = 0.96), moderately correlated with vitamin B12 (r = 0.27), and weakly correlated with Hcy (r = 0.10). This "high B-vitamin" DP (including folate) was characterised by high intakes of vegetables, fruit and low fibre breakfast cereal, and low intakes of processed meat, white bread, sugar and preserves. No associations were observed between DP z-scores and vascular function at any time point following adjustment for covariates.

CONCLUSION

This study explored a specific hypothesised pathway linking diet to vascular function. Although we found no consistent evidence for an association between a high B-vitamin DP and vascular function, we did observe an association with CRP and triglycerides in secondary analyses. Further analyses using strongly correlated and biologically relevant intermediate variables are required to refine investigations into diet and CVD in longitudinal cohort data.

Identifiants

DOI: 10.1016/j.clnu.2018.06.969 PMID: 30005901 PMC: PMC6546956

pubmed: 30005901

pii: S0261-5614(18)31188-9

doi: 10.1016/j.clnu.2018.06.969

pmc: PMC6546956

pii:

doi:

Substances chimiques

Homocysteine 0LVT1QZ0BA

Vitamin B Complex 12001-76-2

Folic Acid 935E97BOY8

Vitamin B 12 P6YC3EG204

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng