Environmental (Lifestyle) Risk Factors for LADA.
LADA
case-control
cohort
etiology
latent autoimmune diabetes in adults
lifestyle
risk factors.
Journal
Current diabetes reviews
ISSN: 1875-6417
Titre abrégé: Curr Diabetes Rev
Pays: United Arab Emirates
ID NLM: 101253260
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
04
2018
revised:
27
04
2018
accepted:
30
06
2018
pubmed:
17
7
2018
medline:
10
8
2019
entrez:
17
7
2018
Statut:
ppublish
Résumé
In order to prevent diabetes it is important to identify common, modifiable risk factors in the population. Such knowledge is extensive for type 2 diabetes but limited for autoimmune forms of diabetes. This review aims at summarizing the limited literature on potential environmental (lifestyle) risk factors for LADA. A PubMed search identified 15 papers estimating the risk of LADA in relation to lifestyle. These were based on data from two population-based studies; one Swedish case-control study and one Norwegian cohort study. Studies published to date indicate that the risk of LADA is associated with factors promoting insulin resistance and type 2 diabetes such as overweight, physical inactivity, smoking, low birth weight, sweetened beverage intake and moderate alcohol consumption (protective). Findings also indicate potential effects on autoimmunity exerted by intake of coffee (harmful) and fatty fish (protective). This supports the concept of LADA as being a hybrid form of diabetes with an etiology including factors associated with both insulin resistance and autoimmunity. LADA may in part be preventable through the same lifestyle modifications as type 2 diabetes including weight loss, physical activity and smoking cessation. However, current knowledge is hampered by the small number of studies and the fact that they exclusively are based on Scandinavian populations. There is a great need for additional studies exploring the role of lifestyle factors in the development of LADA.
Sections du résumé
BACKGROUND
BACKGROUND
In order to prevent diabetes it is important to identify common, modifiable risk factors in the population. Such knowledge is extensive for type 2 diabetes but limited for autoimmune forms of diabetes.
OBJECTIVE
OBJECTIVE
This review aims at summarizing the limited literature on potential environmental (lifestyle) risk factors for LADA.
METHODS
METHODS
A PubMed search identified 15 papers estimating the risk of LADA in relation to lifestyle. These were based on data from two population-based studies; one Swedish case-control study and one Norwegian cohort study.
RESULTS
RESULTS
Studies published to date indicate that the risk of LADA is associated with factors promoting insulin resistance and type 2 diabetes such as overweight, physical inactivity, smoking, low birth weight, sweetened beverage intake and moderate alcohol consumption (protective). Findings also indicate potential effects on autoimmunity exerted by intake of coffee (harmful) and fatty fish (protective). This supports the concept of LADA as being a hybrid form of diabetes with an etiology including factors associated with both insulin resistance and autoimmunity.
CONCLUSION
CONCLUSIONS
LADA may in part be preventable through the same lifestyle modifications as type 2 diabetes including weight loss, physical activity and smoking cessation. However, current knowledge is hampered by the small number of studies and the fact that they exclusively are based on Scandinavian populations. There is a great need for additional studies exploring the role of lifestyle factors in the development of LADA.
Identifiants
pubmed: 30009710
pii: CDR-EPUB-91734
doi: 10.2174/1573399814666180716150253
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
178-187Informations de copyright
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