Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway.
Amylin Receptor Agonists
/ pharmacology
Animals
Antineoplastic Agents, Phytogenic
/ pharmacology
Apoptosis
/ drug effects
Cyclic AMP-Dependent Protein Kinases
/ metabolism
Glucagon-Like Peptide-1 Receptor
/ metabolism
Insulin-Secreting Cells
/ metabolism
Insulinoma
/ metabolism
Islet Amyloid Polypeptide
/ pharmacology
Pancreatic Neoplasms
/ metabolism
Rats
Signal Transduction
Silybin
/ pharmacology
Transcriptional Activation
Tumor Cells, Cultured
Up-Regulation
Apoptosis
GLP-1R
INS-1 cells
PKA
Silibinin
Journal
Molecular and cellular biochemistry
ISSN: 1573-4919
Titre abrégé: Mol Cell Biochem
Pays: Netherlands
ID NLM: 0364456
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
13
02
2018
accepted:
13
07
2018
pubmed:
20
7
2018
medline:
19
3
2019
entrez:
20
7
2018
Statut:
ppublish
Résumé
The objective was to investigate the mechanism of the protective effect of silibinin on amylin/Aβ
Identifiants
pubmed: 30022448
doi: 10.1007/s11010-018-3414-9
pii: 10.1007/s11010-018-3414-9
doi:
Substances chimiques
Amylin Receptor Agonists
0
Antineoplastic Agents, Phytogenic
0
Glucagon-Like Peptide-1 Receptor
0
Islet Amyloid Polypeptide
0
Silybin
4RKY41TBTF
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-94Subventions
Organisme : Innovation and Entrepreneurship Training Program of Shenyang Pharmaceutical University
ID : 201710163000006
Organisme : Foundation of Liaoning Education Committee
ID : 51120427
Organisme : Doctoral Starting up Foundation of Liaoning Science and Technology Department
ID : 51120390
Références
Biopolymers. 2001;60(6):438-59
pubmed: 12209476
Endocr Rev. 2002 Oct;23(5):599-622
pubmed: 12372842
Regul Pept. 2003 Mar 28;111(1-3):55-60
pubmed: 12609749
Diabetes. 2004 Jun;53(6):1509-16
pubmed: 15161755
Int J Biochem Cell Biol. 2004 Dec;36(12):2405-19
pubmed: 15325581
Neurology. 2005 May 10;64(9):1553-62
pubmed: 15883316
Curr Alzheimer Res. 2005 Jul;2(3):377-85
pubmed: 15974903
Diabetes Metab Res Rev. 2006 Jan-Feb;22(1):64-71
pubmed: 16028217
Diabetes. 2005 Dec;54 Suppl 2:S108-13
pubmed: 16306327
Cell Metab. 2006 Nov;4(5):391-406
pubmed: 17084712
Gastroenterology. 2007 May;132(6):2131-57
pubmed: 17498508
Endocrinology. 2007 Oct;148(10):4965-73
pubmed: 17584962
Physiol Rev. 2007 Oct;87(4):1409-39
pubmed: 17928588
Am J Clin Nutr. 2008 Jan;87(1):126-31
pubmed: 18175745
Endocr Rev. 2008 May;29(3):367-79
pubmed: 18292465
Endocr Rev. 2008 May;29(3):303-16
pubmed: 18314421
Neurobiol Aging. 2010 Sep;31(9):1503-15
pubmed: 18950899
J Biol Chem. 2009 Apr 17;284(16):10728-36
pubmed: 19244230
FEBS J. 2010 Mar;277(6):1348-58
pubmed: 20148964
J Pharmacol Sci. 2010;113(1):48-56
pubmed: 20431246
Methods Mol Biol. 1984;1:1-3
pubmed: 20512668
Neuropharmacology. 2011 May;60(6):910-20
pubmed: 21277873
Am J Pathol. 2011 Jun;178(6):2632-40
pubmed: 21641386
Physiol Rev. 2011 Jul;91(3):795-826
pubmed: 21742788
J Mol Biol. 2012 Aug 10;421(2-3):348-63
pubmed: 22321797
J Asian Nat Prod Res. 2012;14(5):413-23
pubmed: 22423887
Diabetes Obes Metab. 2013 Jan;15(1):15-27
pubmed: 22776039
CNS Neurol Disord Drug Targets. 2012 Dec;11(8):1045-51
pubmed: 23244428
Diabetologia. 2013 Mar;56(3):508-19
pubmed: 23262664
Biochem Biophys Res Commun. 2013 Mar 8;432(2):314-9
pubmed: 23396055
Front Aging Neurosci. 2013 Aug 08;5:38
pubmed: 23964237
Front Aging Neurosci. 2013 Aug 15;5:42
pubmed: 23966942
Med Sci (Paris). 2014 Jan;30(1):82-92
pubmed: 24472464
Trends Pharmacol Sci. 2014 Mar;35(3):127-35
pubmed: 24560688
Neuroscience. 2014 Sep 26;277:6-13
pubmed: 24583037
J Inorg Biochem. 2014 Nov;140:143-52
pubmed: 25108186
J Alzheimers Dis. 2015;44(1):43-8
pubmed: 25190626
CNS Neurol Disord Drug Targets. 2015;14(3):370-7
pubmed: 25544681
Can J Diabetes. 2015 Oct;39(5):383-9
pubmed: 25840943
Biochem Biophys Res Commun. 2015 May 8;460(3):491-6
pubmed: 25843796
Nat Med. 2015 May;21(5):506-11
pubmed: 25849133
Front Neurosci. 2015 Jun 16;9:216
pubmed: 26136651
Nat Rev Drug Discov. 2015 Nov;14(11):759-80
pubmed: 26338154
Physiol Behav. 2016 Aug 1;162:130-40
pubmed: 26922873
World J Diabetes. 2016 May 10;7(9):189-97
pubmed: 27162583
J Alzheimers Dis. 2016 May 5;53(1):259-72
pubmed: 27163815
Biomed Res Int. 2016;2016:1421430
pubmed: 27403417
Biochemistry. 2016 Aug 9;55(31):4255-8
pubmed: 27431615
Mol Neurobiol. 2017 Sep;54(7):5427-5439
pubmed: 27596506
Neurochem Res. 2017 Apr;42(4):1073-1083
pubmed: 28004303
Mol Psychiatry. 2017 Sep;22(9):1327-1334
pubmed: 28044060
J Alzheimers Dis. 2017;59(2):421-432
pubmed: 28269785
Biomed Pharmacother. 2017 May;89:681-688
pubmed: 28273632
Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):107-113
pubmed: 28538088
Physiol Behav. 2017 Oct 1;179:487-493
pubmed: 28735062
Neurochem Res. 2018 Apr;43(4):796-805
pubmed: 29397533
Biomed Pharmacother. 2018 Jun;102:344-353
pubmed: 29571019
Sci Rep. 2018 Apr 10;8(1):5734
pubmed: 29636531
Hepatology. 1996 Apr;23(4):749-54
pubmed: 8666328
Biochem J. 1997 Aug 15;326 ( Pt 1):1-16
pubmed: 9337844
Trends Cell Biol. 1998 Jul;8(7):267-71
pubmed: 9714597