Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction.
Aged
Aged, 80 and over
Biomarkers
/ blood
Female
Germany
Hemodynamics
Humans
Hypothermia, Induced
/ adverse effects
Lactic Acid
/ blood
Male
Myocardial Infarction
/ diagnosis
Percutaneous Coronary Intervention
/ adverse effects
Prospective Studies
Recovery of Function
Shock, Cardiogenic
/ diagnosis
Time Factors
Treatment Outcome
hypothermia, induced
myocardial infarction
shock, cardiogenic
Journal
Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763
Informations de publication
Date de publication:
22 01 2019
22 01 2019
Historique:
pubmed:
22
7
2018
medline:
19
11
2019
entrez:
21
7
2018
Statut:
ppublish
Résumé
Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicating acute myocardial infarction. Patients (n=40) with cardiogenic shock undergoing primary percutaneous coronary intervention without classic indications for mild therapeutic hypothermia underwent randomization in a 1:1 fashion to mild therapeutic hypothermia for 24 hours or control. The primary end point was cardiac power index at 24 hours; secondary end points included other hemodynamic parameters and serial measurements of arterial lactate. No relevant differences were observed for the primary end point of cardiac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0.31-0.52] versus 0.36 [interquartile range, 0.31-0.48] W/m In this randomized trial, mild therapeutic hypothermia failed to show a substantial beneficial effect on cardiac power index at 24 hours in patients with cardiogenic shock after acute myocardial infarction. URL: https://www.clinicaltrials.gov . Unique identifier: NCT01890317.
Sections du résumé
BACKGROUND
Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicating acute myocardial infarction.
METHODS
Patients (n=40) with cardiogenic shock undergoing primary percutaneous coronary intervention without classic indications for mild therapeutic hypothermia underwent randomization in a 1:1 fashion to mild therapeutic hypothermia for 24 hours or control. The primary end point was cardiac power index at 24 hours; secondary end points included other hemodynamic parameters and serial measurements of arterial lactate.
RESULTS
No relevant differences were observed for the primary end point of cardiac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0.31-0.52] versus 0.36 [interquartile range, 0.31-0.48] W/m
CONCLUSIONS
In this randomized trial, mild therapeutic hypothermia failed to show a substantial beneficial effect on cardiac power index at 24 hours in patients with cardiogenic shock after acute myocardial infarction.
CLINICAL TRIAL REGISTRATION
URL: https://www.clinicaltrials.gov . Unique identifier: NCT01890317.
Identifiants
pubmed: 30026282
pii: CIRCULATIONAHA.117.032722
doi: 10.1161/CIRCULATIONAHA.117.032722
doi:
Substances chimiques
Biomarkers
0
Lactic Acid
33X04XA5AT
Banques de données
ClinicalTrials.gov
['NCT01890317']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
448-457Commentaires et corrections
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