Autism-related behaviors in the cyclooxygenase-2-deficient mouse model.
COX2
age differences
autism
behavior
gene expression
inverted screen test
knockin model
lipid signaling
marble burying test
neurodevelopmental disorders
open field test
prostaglandin
sex differences
three-chamber sociability test
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
17
05
2018
revised:
16
07
2018
accepted:
16
07
2018
pubmed:
22
7
2018
medline:
22
3
2019
entrez:
21
7
2018
Statut:
ppublish
Résumé
Prostaglandin E2 (PGE2) is an endogenous lipid molecule involved in normal brain development. Cyclooxygenase-2 (COX2) is the main regulator of PGE2 synthesis. Emerging clinical and molecular research provides compelling evidence that abnormal COX2/PGE2 signaling is associated with autism spectrum disorder (ASD). We previously found that COX2 knockout mice had dysregulated expression of many ASD genes belonging to important biological pathways for neurodevelopment. The present study is the first to show the connection between irregular COX2/PGE2 signaling and autism-related behaviors in male and female COX2-deficient knockin, (COX)-2
Substances chimiques
Grm5 protein, mouse
0
Receptor, Metabotropic Glutamate 5
0
Wnt2 Protein
0
Cyclooxygenase 2
EC 1.14.99.1
Matrix Metalloproteinase 9
EC 3.4.24.35
Mmp9 protein, mouse
EC 3.4.24.35
Glo1 protein, mouse
EC 4.4.1.5
Lactoylglutathione Lyase
EC 4.4.1.5
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12506Informations de copyright
© 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.