Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report.
High-dose hook
ferritin
haemophagocytic lymphohistiocytosis
prozone
Journal
Annals of clinical biochemistry
ISSN: 1758-1001
Titre abrégé: Ann Clin Biochem
Pays: England
ID NLM: 0324055
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
22
7
2018
medline:
4
12
2019
entrez:
21
7
2018
Statut:
ppublish
Résumé
The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking.
Identifiants
pubmed: 30027777
doi: 10.1177/0004563218793166
pmc: PMC6299261
doi:
Substances chimiques
Ferritins
9007-73-2
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-182Références
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