Gut-derived serotonin contributes to bone deficits in colitis.

Animals Bone Resorption / diagnostic imaging Colitis / chemically induced Dextran Sulfate Femur / diagnostic imaging Intestinal Mucosa / metabolism Male Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Serotonin / metabolism Serotonin Plasma Membrane Transport Proteins / genetics X-Ray Microtomography
5-HT(1B) receptor DSS-induced colitis Peripheral 5-HT bone loss

Journal

Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422

Informations de publication

Date de publication:
02 2019
Historique:
received: 23 02 2018
revised: 14 06 2018
accepted: 16 07 2018
pubmed: 22 7 2018
medline: 14 5 2019
entrez: 22 7 2018
Statut: ppublish

Résumé

Osteoporosis and bone fractures occur at higher frequency in patients with inflammatory bowel disease (IBD), and decreased bone mass is observed in animal models of colitis. Another consistent feature of colitis is increased serotonin (5-HT) availability in the intestinal mucosa. Since gut-derived 5-HT can decrease bone mass, via activation of 5-HT

Identifiants

DOI: 10.1016/j.phrs.2018.07.018 PMID: 30030171 PMC: PMC6336528
pubmed: 30030171
pii: S1043-6618(18)30234-2
doi: 10.1016/j.phrs.2018.07.018
pmc: PMC6336528
mid: NIHMS1501954
pii:
doi:

Substances chimiques

Serotonin Plasma Membrane Transport Proteins 0
Serotonin 333DO1RDJY
Dextran Sulfate 9042-14-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

75-84

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK062267
Pays : United States
Organisme : NIDCR NIH HHS
ID : R37 DE012528
Pays : United States
Organisme : NIDCR NIH HHS
ID : R56 DE012528
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

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Auteurs

B Lavoie (B)

Department of Neurological Sciences, The University of Vermont, Burlington, VT, USA. Electronic address: blavoie@uvm.edu.

J A Roberts (JA)

Department of Neurological Sciences, The University of Vermont, Burlington, VT, USA.

M M Haag (MM)

Department of Neurological Sciences, The University of Vermont, Burlington, VT, USA.

S N Spohn (SN)

Department of Neurological Sciences, The University of Vermont, Burlington, VT, USA.

K G Margolis (KG)

Department of Pediatrics, Columbia University, New York, NY, USA.

K A Sharkey (KA)

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.

J B Lian (JB)

Department of Biochemistry, The University of Vermont, Burlington, VT, USA.

G M Mawe (GM)

Department of Neurological Sciences, The University of Vermont, Burlington, VT, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Sulfate dextran › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Appareil locomoteur › Squelette › Os du membre inférieur › Fémur › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la sérotonine › Gut-derived serotonin contributes to bone...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › Gut-derived serotonin contributes to bone...