Structural characterization of a Δ

Amino Acid Sequence Dodecenoyl-CoA Isomerase / chemistry Fatty Acids, Unsaturated / chemistry Isomerases / chemistry Lipid Metabolism Models, Molecular Molecular Dynamics Simulation Protein Array Analysis Protein Binding Protein Conformation Pseudomonas aeruginosa / enzymology Structure-Activity Relationship
None crystal structure diffusible signal factors isomerase unsaturated fatty acid

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
Jul 2019
Historique:
pubmed: 28 7 2018
medline: 25 6 2020
entrez: 28 7 2018
Statut: ppublish

Résumé

Gene PA4980 from Pseudomonas aeruginosa encodes a putative enoyl-coenzyme A hydratase/isomerase that is associated with the function of the biofilm dispersion-inducing signal molecule cis-2-decenoic acid. To elucidate the role of PA4980 in cis-2-decenoic acid biosynthesis, we reported the crystal structure of its protein product at 2.39 Å. The structural analysis and substrate binding prediction suggest that it acts as a monofunctional enoyl-coenzyme A isomerase, implicating an alternative pathway of the cis-2-decenoic acid synthesis.

Identifiants

DOI: 10.1080/07391102.2018.1495102 PMID: 30052139
pubmed: 30052139
doi: 10.1080/07391102.2018.1495102
doi:

Substances chimiques

Fatty Acids, Unsaturated 0
Isomerases EC 5.-
Dodecenoyl-CoA Isomerase EC 5.3.3.8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2695-2702

Auteurs

Li Liu (L)

a Department of Dermatology , Affiliated Hospital, Southwest Medical University , Luzhou , China.
b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Tao Li (T)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Cui-Ting Peng (CT)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Chang-Zhen Sun (CZ)

e Drug Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Traditional Chinese Medicine Hospital , Southwest Medical University , Luzhou , China.

Chang-Cheng Li (CC)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Qing-Jie Xiao (QJ)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Li-Hui He (LH)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Ning-Yu Wang (NY)

c School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.

Ying-Jie Song (YJ)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Yi-Bo Zhu (YB)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Hong Li (H)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Mei Kang (M)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Hong Tang (H)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.

Xia Xiong (X)

a Department of Dermatology , Affiliated Hospital, Southwest Medical University , Luzhou , China.

Rui Bao (R)

b Center of Infectious Diseases, West China Hospital , Sichuan University , Chengdu , P.R. China.
d State Key Laboratory of Biotherapy and Cancer Center and Healthy Food Evaluation Research Center , Sichuan University , Chengdu , P.R. China.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Structural characterization of a Δ
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Intramolecular oxidoreductases › Carbon-carbon double bond isomerases › Dodecenoyl-CoA isomerase › Structural characterization of a Δ
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Structural characterization of a Δ
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Structural characterization of a Δ
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Structural characterization of a Δ
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural characterization of a Δ
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Structural characterization of a Δ
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Analyse par réseau de protéines › Structural characterization of a Δ
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural characterization of a Δ
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural characterization of a Δ
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Structural characterization of a Δ
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structural characterization of a Δ