Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.
Adolescent
Adult
Autoantibodies
/ analysis
Autoimmunity
/ genetics
Child
Child, Preschool
Diabetes Mellitus, Type 1
/ diagnosis
Disease Progression
Diseases in Twins
/ diagnosis
Environment
Female
Genetic Predisposition to Disease
Glutamate Decarboxylase
/ immunology
Humans
Insulin
/ metabolism
Islets of Langerhans
/ immunology
Male
Mass Screening
/ methods
Risk Factors
Seroepidemiologic Studies
Siblings
Twins
/ genetics
Twins, Dizygotic
/ genetics
Twins, Monozygotic
/ genetics
Young Adult
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
07
02
2018
accepted:
28
06
2018
pubmed:
1
8
2018
medline:
25
7
2019
entrez:
1
8
2018
Statut:
ppublish
Résumé
There are variable reports of risk of concordance for progression to islet autoantibodies and type 1 diabetes in identical twins after one twin is diagnosed. We examined development of positive autoantibodies and type 1 diabetes and the effects of genetic factors and common environment on autoantibody positivity in identical twins, nonidentical twins, and full siblings. Subjects from the TrialNet Pathway to Prevention Study ( At screening, identical twins were more likely to have positive GADA, IA-2A, and IAA than nonidentical twins or full siblings (all Risk of type 1 diabetes at 3 years is high for initially multiple and single autoantibody-positive identical twins and multiple autoantibody-positive nonidentical twins. Genetic predisposition, age, and male sex are significant risk factors for development of positive autoantibodies in twins.
Identifiants
pubmed: 30061316
pii: dc18-0288
doi: 10.2337/dc18-0288
pmc: PMC6341285
doi:
Substances chimiques
Autoantibodies
0
Insulin
0
Glutamate Decarboxylase
EC 4.1.1.15
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Pagination
192-199Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK061010
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103153
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK065522
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK045735
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Investigateurs
Carla J Greenbaum
(CJ)
M Atkinson
(M)
D Baidal
(D)
M Battaglia
(M)
D Becker
(D)
P Bingley
(P)
E Bosi
(E)
J Buckner
(J)
M Clements
(M)
P Colman
(P)
L DiMeglio
(L)
S Gitelman
(S)
R Goland
(R)
P Gottlieb
(P)
K Herold
(K)
M Knip
(M)
J Krischer
(J)
A Lernmark
(A)
W Moore
(W)
A Moran
(A)
A Muir
(A)
J Palmer
(J)
M Peakman
(M)
L Philipson
(L)
P Raskin
(P)
M Redondo
(M)
H Rodriguez
(H)
W Russell
(W)
L Spain
(L)
D A Schatz
(DA)
J Sosenko
(J)
J Wentworth
(J)
D Wherrett
(D)
D Wilson
(D)
W Winter
(W)
A Ziegler
(A)
M Anderson
(M)
P Antinozzi
(P)
C Benoist
(C)
J Blum
(J)
K Bourcier
(K)
P Chase
(P)
M Clare-Salzler
(M)
R Clynes
(R)
G Eisenbarth
(G)
C G Fathman
(CG)
G Grave
(G)
B Hering
(B)
R Insel
(R)
F Kaufman
(F)
T Kay
(T)
E Leschek
(E)
J Mahon
(J)
J B Marks
(JB)
K Nanto-Salonen
(K)
G Nepom
(G)
T Orban
(T)
R Parkman
(R)
M Pescovitz
(M)
J Peyman
(J)
A Pugliese
(A)
B Roep
(B)
M Roncarolo
(M)
P Savage
(P)
O Simell
(O)
R Sherwin
(R)
M Siegelman
(M)
J S Skyler
(JS)
A Steck
(A)
J Thomas
(J)
M Trucco
(M)
J Wagner
(J)
Jeffrey P Krischer
(JP)
Ellen Leschek
(E)
Lisa Rafkin
(L)
Katarzyna Bourcier
(K)
Catherine Cowie
(C)
Mary Foulkes
(M)
Richard Insel
(R)
Heidi Krause-Steinrauf
(H)
John M Lachin
(JM)
Saul Malozowski
(S)
John Peyman
(J)
John Ridge
(J)
Peter Savage
(P)
Jay S Skyler
(JS)
Stephanie J Zafonte
(SJ)
Lisa Rafkin
(L)
Jay M Sosenko
(JM)
Norma S Kenyon
(NS)
Irene Santiago
(I)
Jeffrey P Krischer
(JP)
Brian Bundy
(B)
Michael Abbondondolo
(M)
Timothy Adams
(T)
Darlene Amado
(D)
Ilma Asif
(I)
Matthew Boonstra
(M)
Cristina Burroughs
(C)
David Cuthbertson
(D)
Mary Deemer
(M)
Christopher Eberhard
(C)
Steve Fiske
(S)
Julie Ford
(J)
Jennifer Garmeson
(J)
Heather Guillette
(H)
Susan Geyer
(S)
Brian Hays
(B)
Courtney Henderson
(C)
Martha Henry
(M)
Kathleen Heyman
(K)
Belinda Hsiao
(B)
Christina Karges
(C)
Nichole Keaton
(N)
Amanda Kinderman
(A)
Pat Law
(P)
Ashely Leinbach
(A)
Shu Liu
(S)
Jennifer Lloyd
(J)
Jamie Malloy
(J)
Kristin Maddox
(K)
Julie Martin
(J)
Jessica Miller
(J)
Eric Milliot
(E)
Margaret Moore
(M)
Sarah Muller
(S)
Thuy Nguyen
(T)
Ryan O'Donnell
(R)
Amy Roberts
(A)
Kelly Sadler
(K)
Tina Stavros
(T)
Roy Tamura
(R)
Keith Wood
(K)
Ping Xu
(P)
Kenneth Young
(K)
Persida Alies
(P)
Franz Badias
(F)
Aaron Baker
(A)
Monica Bassi
(M)
Craig Beam
(C)
David Boulware
(D)
London Bounmananh
(L)
Susan Bream
(S)
Doug Freeman
(D)
Jessica Gough
(J)
Jinin Ginem
(J)
Moriah Granger
(M)
Mary Holloway Michelle Kieffer
(MH)
Page Lane
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Cristin Linton
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Lavanya Nallamshetty
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Vanessa Oduah
(V)
Yazandra Parrimon
(Y)
Kate Paulus
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Jennifer Pilger
(J)
Joy Ramiro
(J)
AQesha Luvon Ritzie
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Archana Sharma
(A)
Audrey Shor
(A)
Xiaohong Song
(X)
Amanda Terry
(A)
Jeanne Weinberger
(J)
Margaret Wootten
(M)
John M Lachin
(JM)
Mary Foulkes
(M)
Pamela Harding
(P)
Heidi Krause-Steinrauf
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Susan McDonough
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Paula F McGee
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Kimberly Owens Hess
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Scott Quinlan
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Erica Raiden
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Emily Batts
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Chris Buddy
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Kristin Kirpatrick
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Ann Shultz
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Melita Romesco
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Ellen Leschek
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Lisa Spain
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Sean Aas
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Emily Blumberg
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Gerald Beck
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David Brillon
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Rose Gubitosi-Klug
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Lori Laffel
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Robert Vigersky
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Dennis Wallace
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Jonathan Braun
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Bernard Lo
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Herman Mitchell
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Ali Naji
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Jorn Nerup
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Michael Green
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Santica Marcovina
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Jerry P Palmer
(JP)
Adriana Weinberg
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Liping Yu
(L)
Sunanda Babu
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William Winter
(W)
George S Eisenbarth
(GS)
Polly Bingley
(P)
Raphael Clynes
(R)
Linda DiMeglio
(L)
George Eisenbarth
(G)
Brian Hays
(B)
Ellen Leschek
(E)
Jennifer Marks
(J)
Della Matheson
(D)
Lisa Rafkin
(L)
Henry Rodriguez
(H)
Lisa Spain
(L)
Darrell Wilson
(D)
Maria Redondo
(M)
David Gomez
(D)
Andrene McDonald
(A)
Sandra Pena
(S)
Massimo Pietropaolo
(M)
Kathy Shippy
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Emily Batts
(E)
Tyler Brown
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Jared Odegard
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Christine Webber
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Minna Romo
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(K)
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(O)
Tuula Simell
(T)
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(E)
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(J)
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(L)
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(M)
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(V)
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(D)
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(J)
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(C)
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(RJ)
W Lane
(W)
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R Field
(R)
K J Walker
(KJ)
L Griffin
(L)
C Bartholow
(C)
J Erickson
(J)
B Howard
(B)
C Krabbenhoft
(C)
A Sandman
(A)
J Vanveldhuizen
(J)
A Wurlger
(A)
K Zimmerman
(K)
L Hanisch
(L)
A Davis-Keppen
(A)
J Cotterill
(J)
M Kirby
(M)
A Harris
(A)
C Schmidt
(C)
C Kishiyama
(C)
J Flores
(J)
W Milton
(W)
C Martin
(C)
A Whysham
(A)
T Yerka
(T)
J M Freels
(JM)
J Hassing
(J)
R Webster
(R)
P Green
(P)
J Carter
(J)
D Galloway
(D)
S Hoelzer
(S)
S Roberts
(S)
P Said
(P)
H F Sullivan
(HF)
E Allen
(E)
E Reiter
(E)
C Feinberg
(C)
L A Johnson
(LA)
D Newhook
(D)
N H Hagerty
(NH)
L White
(L)
J Levandoski
(J)
M Kyllo
(M)
C Johnson
(C)
P Benoit
(P)
F Iyer
(F)
H Diamond
(H)
S Hosono
(S)
L Jackman
(L)
P Barette
(P)
I Jones
(I)
S Sills
(S)
J Bzdick
(J)
R Bulger
(R)
I Weinstock
(I)
R Douek
(R)
G Andrews
(G)
G Modgill
(G)
L Gyorffy
(L)
N Robin
(N)
S Vaidya
(S)
K Crouch
(K)
C O'Brien
(C)
N Thompson
(N)
J Thorne
(J)
J Blumer
(J)
L Kalic
(L)
J Klepek
(J)
B Paulett
(B)
J Rosolowski
(J)
M Horner
(M)
J L Watkins
(JL)
K Casey
(K)
C Carpenter
(C)
J Burns
(J)
C Horton
(C)
D Pritchard
(D)
A G Soetaert
(AG)
C Wynne
(C)
O Y Chin
(OY)
C Molina
(C)
R Patel
(R)
M Senguttuvan
(M)
O Wheeler
(O)
C Furet
(C)
D H Steuhm
(DH)
S Jelley
(S)
L Goudeau
(L)
D Chalmers
(D)
C Greer
(C)
D L Panagiotopoulos
(DL)
D Metzger
(D)
M Nguyen
(M)
M P Horowitz
(MP)
E Christiansen
(E)
C Glades
(C)
M Morimoto
(M)
R Macarewich
(R)
K Norman
(K)
C Patin
(C)
A Vargas
(A)
A Barbanica
(A)
P Yu
(P)
W Vaidyanathan
(W)
R Osborne
(R)
S Mehra
(S)
S Kaster
(S)
J Neace
(J)
G Horner
(G)
C Reeves
(C)
L Cordrey
(L)
T Marrs
(T)
S Miller
(S)
D Dowshen
(D)
S Doyle
(S)
D Walker
(D)
H Catte
(H)
M Dean
(M)
B Drury-Brown
(B)
M M C Hackman
(MMC)
S Lee
(S)
K Malkani
(K)
K Cullen
(K)
P Johnson
(P)
M Hampton
(M)
C McCarrell
(C)
E Curtis
(E)
None Paul
Y Zambrano
(Y)
Informations de copyright
© 2018 by the American Diabetes Association.
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