Sedation during minimal invasive surfactant therapy: a randomised controlled trial.
minimal invasive
preterm infant
propofol
sedation/premedication
surfactant
Journal
Archives of disease in childhood. Fetal and neonatal edition
ISSN: 1468-2052
Titre abrégé: Arch Dis Child Fetal Neonatal Ed
Pays: England
ID NLM: 9501297
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
20
02
2018
revised:
28
05
2018
accepted:
06
07
2018
pubmed:
3
8
2018
medline:
27
6
2019
entrez:
3
8
2018
Statut:
ppublish
Résumé
Although sedation for endotracheal intubation of infants is widely adopted, there is no consensus whether sedation should be used for minimal invasive surfactant therapy (MIST). We compared, in a randomised controlled setting, the level of stress and comfort of preterm infants during MIST with and without receiving low-dose sedation. Infants between 26 and 36 weeks gestational age were randomised to receive either low-dose sedation (1 mg/kg propofol intravenous) or no premedication during MIST procedure. Standard comfort care was given in both groups, which consisted of administering sucrose in the cheek pouch of the infant and containment. Primary end point was the percentage of infants assessed to be comfortable during the procedure (COMFORTneo-score <14). Secondary parameters included complications of both the MIST procedure and low-dose sedation administration. In total, 78 infants were randomised and analysed, with a median (IQR) gestational age of 29 Low-dose sedation increased comfort during MIST procedure in preterm infants, but the need for transient non-invasive ventilation was increased. NTR5010, pre-results.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Although sedation for endotracheal intubation of infants is widely adopted, there is no consensus whether sedation should be used for minimal invasive surfactant therapy (MIST). We compared, in a randomised controlled setting, the level of stress and comfort of preterm infants during MIST with and without receiving low-dose sedation.
METHODS
METHODS
Infants between 26 and 36 weeks gestational age were randomised to receive either low-dose sedation (1 mg/kg propofol intravenous) or no premedication during MIST procedure. Standard comfort care was given in both groups, which consisted of administering sucrose in the cheek pouch of the infant and containment. Primary end point was the percentage of infants assessed to be comfortable during the procedure (COMFORTneo-score <14). Secondary parameters included complications of both the MIST procedure and low-dose sedation administration.
RESULTS
RESULTS
In total, 78 infants were randomised and analysed, with a median (IQR) gestational age of 29
CONCLUSION
CONCLUSIONS
Low-dose sedation increased comfort during MIST procedure in preterm infants, but the need for transient non-invasive ventilation was increased.
TRIAL REGISTRATION NUMBER
BACKGROUND
NTR5010, pre-results.
Identifiants
pubmed: 30068669
pii: archdischild-2018-315015
doi: 10.1136/archdischild-2018-315015
doi:
Substances chimiques
Hypnotics and Sedatives
0
Pulmonary Surfactants
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
F378-F383Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.